Stem Cell Research: What the Cell is the Controversy?

UMKC Honors Colleg

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

Political power and the development of the GB renewable heat incentive

This is the final version of the paper. Available from BIEE via the link in this record.A transformation of the UK’s heat system is required to ensure that the goals of sustainable and secure energy are met. This transformation could require a complete shift away from fossil fuels to primarily renewable sources of heat. Like in any transformation, social and political power is likely to be an important factor. This paper documents research which has focussed on the sociopolitical power of actors to affect policy and regulation in the area of UK sustainable heat policy. It draws on theory from the sociological literature around socio-political power and literature around lobbying to examine the GB renewable heat incentive policy. It shows that while there have been numerous attempts to influence GB heat policy, these attempts are limited in their success and unpicking the role actors versus evidence is extremely difficult. The research also shows the methodological complexity of examining political influencing

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

Brief Encounters with Qualitative Methods in Health Research: Phenomenology and Interpretative Phenomenological Analysis

Developed from a strong philosophical tradition, phenomenological research puts human experience at the heart of the research process. Interpretative Phenomenological Analysis, in particular, is a methodological stance that embraces the lived and subjective views of those who experience a given phenomenon. This flexible and descriptive approach provides researchers with an opportunity to depict and situate lived experience in rich contextual detail, while also accounting for the meaning-making of participants. Given the importance of patient/client voice, and a personalised view of health, phenomenological methods such as IPA can contribute extensively to health research by providing rich contextual accounts of experience which shed light on the essences of important phenomena

Spherical harmonic representation of the main geomagnetic field for world charting and investigations of some fundamental problems of physics and geophysics

Quiet-day data from MAGSAT were examined for effects which might test the validity of Maxwell's equations. Both external and toroidal fields which might represent a violation of the equations appear to exist, well within the associated errors. The external field might be associated with the ring current, and varies of a time-scale of one day or less. Its orientation is parallel to the geomagnetic dipole. The toriodal field can be confused with an orientation in error (in yaw). It the toroidal field really exists, its can be related to either ionospheric currents, or to toroidal fields in the Earth's core in accordance with Einstein's unified field theory, or to both

Infrared aircraft measurements of stratospheric composition over Antarctica during September 1987

The JPL Mark IV interferometer recorded high resolution, infared solar spectra from the NASA DC-8 aircraft during flights over Antarctica in September 1987. The atmospheric absorption features in these spectra were analyzed to determine the overburdens of O3, NO, NO2, HNO3, ClONO2, HCl, HF, CH4, N2O, CO, H2O and CFC-12. The spectra were obtained at latitudes which ranged between 64 degrees S and 86 degrees S, allowing the composition in the interior of the polar vortex to be compared with that at the edge. The latitude dependence observed for NO, HO2, HNO3, ClONO2, HCl and HF are summerized. The values at 30 deg S were observed on the ferry flight from New Zealand to Hawaii. The dashed lines connecting the two were interpolated across the region for which there are no measurements. The chemically perturbed region is seen to consist of a collar of high HNO3 and ClONO2 surrounding a core in which the overburdens of these and of HCl and NO2 are very low. Clear increases in the overburdens of HF and HNO3 were observed during the course of September in the vortex core. HCl and NO2 exhibited smaller, less significant increases. The overburdens of the tropospheric source gases, N2O, CH4, CF2Cl2, and H2O were observed to much smaller over Antarctica than at mid-latitudes. This, together with the fact that HF over Antarctica was more that double its mid-latitude value, suggests that downwelling has occurred

Fragility curves for non-ductile reinforced concrete frames that exhibit different component response mechanisms

Around the world, a large percentage of buildings in regions of high seismicity are older, non-ductile reinforced concrete. To assess the risk posed by these buildings, fragility functions are required to define the likelihood that these buildings will sustain damage and collapse under earthquake loading. This paper presents the initial phase of a research effort to develop fragility functions for non-ductile concrete frames using numerical simulation; the research presented in this paper focuses on development of the numerical model and application of the model to develop fragility functions for a prototype non-ductile concrete frame. To enable numerical simulation of concrete frame buildings, response models for beam–column joints and columns are developed to provide (1) appropriate simulation of component response and, thereby, reliable assessment of risk and (2) computational efficiency and robustness. These new models are developed using existing experimental data, build on response models proposed by others, and employ component and material models available in the OpenSees analysis platform (http://opensees.berkeley.edu). A new beam–column joint model combines a new expression for joint strength and newly developed cyclic response parameters; a new column response model includes a new shear-strength model and newly developed cyclic response parameters. Numerical models of a prototype non-ductile concrete frame are developed that include simulation of one or more of the following characteristics: (1) rigid beam–column joint, (2) nonlinear joint shear response, (3) nonlinear joint shear and bond–slip response, and (4) column shear failure. Dynamic analyses are performed using these frame models and a suite of ground motions; analysis results are used to develop fragility curves. Fragility curves quantify the vulnerability of the frame and provide understanding of the impact of different component failure mechanisms on frame vulnerability.This research was supported by the National Science Foundation under NSF Grant # 1000700.This is the accepted manuscript of a paper published in Engineering Structures (J-S Jeon, LN Lowes, R DesRoches, I Brilakis, Engineering Structures 2015, 85, 127–143