Chow's theorem and universal holonomic quantum computation

A theorem from control theory relating the Lie algebra generated by vector fields on a manifold to the controllability of the dynamical system is shown to apply to Holonomic Quantum Computation. Conditions for deriving the holonomy algebra are presented by taking covariant derivatives of the curvature associated to a non-Abelian gauge connection. When applied to the Optical Holonomic Computer, these conditions determine that the holonomy group of the two-qubit interaction model contains $SU(2) \times SU(2)$. In particular, a universal two-qubit logic gate is attainable for this model.Comment: 13 page

Theoretical Investigation of Optical Conductivity in Ba [Fe(1-x)Co(x)]2 As2

We report on theoretical calculations of the optical conductivity of Ba [Fe(1-x)Co(x)]2 As2, as obtained from density functional theory within the full potential LAPW method. A thorough comparison with experiment shows that we are able to reproduce most of the observed experimental features, in particular a magnetic peak located at about 0.2 eV which we ascribe to antiferromagnetic ordered magnetic stripes. We also predict a large in-plane anisotropy of this feature, which agrees very well with measurements on detwinned crystals. The effect of Co doping as well as the dependence of plasma frequency on the magnetic order is also investigated

Mind the gap: IR and the challenge of international politics

The discipline of International Relations (IR) for a long time of its history has developed in the form of Great Debates that involved competing paradigms and schools. More recently, it has been described as a cacophony of voices unable to communicate among themselves, but also incapable to provide keys to understand an ever more complex reality. This collection aims at evaluating the heuristic value of a selection of traditional paradigmsrealism and liberalism), schools (constructivism), and subdisciplines (security studies and international political economy) so as to assess the challenges before IR theory today and the ability of the discipline to provide tools to make the changed world still intelligible

Xenosurveillance reflects traditional sampling techniques for the identification of human pathogens: A comparative study in West Africa

BACKGROUND: Novel surveillance strategies are needed to detect the rapid and continuous emergence of infectious disease agents. Ideally, new sampling strategies should be simple to implement, technologically uncomplicated, and applicable to areas where emergence events are known to occur. To this end, xenosurveillance is a technique that makes use of blood collected by hematophagous arthropods to monitor and identify vertebrate pathogens. Mosquitoes are largely ubiquitous animals that often exist in sizable populations. As well, many domestic or peridomestic species of mosquitoes will preferentially take blood-meals from humans, making them a unique and largely untapped reservoir to collect human blood. METHODOLOGY/PRINCIPAL FINDINGS: We sought to take advantage of this phenomenon by systematically collecting blood-fed mosquitoes during a field trail in Northern Liberia to determine whether pathogen sequences from blood engorged mosquitoes accurately mirror those obtained directly from humans. Specifically, blood was collected from humans via finger-stick and by aspirating bloodfed mosquitoes from the inside of houses. Shotgun metagenomic sequencing of RNA and DNA derived from these specimens was performed to detect pathogen sequences. Samples obtained from xenosurveillance and from finger-stick blood collection produced a similar number and quality of reads aligning to two human viruses, GB virus C and hepatitis B virus. CONCLUSIONS/SIGNIFICANCE: This study represents the first systematic comparison between xenosurveillance and more traditional sampling methodologies, while also demonstrating the viability of xenosurveillance as a tool to sample human blood for circulating pathogens

Autocrine signals increase Ovine Mesenchymal Stem Cells migration throughAquaporin-1 and CXCR4 overexpression

Sheep is a relevant large animal model that is frequently used to test innovative tissue engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells (MSCs) are used in TE applications because they represent key component of adult tissue repair. Importantly, MSCs from different species show similar characteristics, which facilitated their application in translational studies using animal models. Nowadays, many researches are focusing on the use of ovine mesenchymal stem cells (oMSCs) in orthopedic preclinical settings for regenerative medicine purposes. Therefore, there is a need to amplify our knowledge on the mechanisms underlying the behaviour of these cells. Recently, several studies have shown that MSC function is largely dependent on factors that MSCs release in the environment as well as in conditioned medium (CM). It has been demonstrated that MSCs through autocrine and paracrine signals are able to stimulate proliferation, migration and differentiation of different type of cells including themselves. In this study, we investigated the effects of the CM produced by oMSCs on oMSCs themselves and we explored the signal pathways involved. We observed that CM caused an enhancement of oMSC migration. Furthermore, we found that CM increased levels of two membrane proteins involved in cell migration, Aquaporin 1 (AQP1) and C-X-C chemokine receptor type 4 (CXCR4), and activated Akt and Erk intracellular signal pathways

High prevalence of anti-hepatitis e virus antibodies among blood donors in central Italy, february to march 2014

Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23–3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18–64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection. © 2016, European Centre for Disease Prevention and Control

The control of catalytic performance of rutile-type Sn/V/Nb/Sb mixed oxides, catalysts for propane ammoxidation to acrylonitrile

This paper describes the effect of the composition of rutile-type Sn/V/Nb/Sb mixed oxides catalysts on the catalytic performance in the gas-phase ammoxidation of propane to acrylonitrile. The variation in the atomic ratio between components in catalysts is the key for the control of activity and selectivity. In samples with atomic composition Sn/V/Nb/Sb 1/0.2/1/x (0 x 5) and 1/0.2/y/3 (0 y 3) several compounds formed, i.e., SnO2, Sb/Nbmixed oxide, Sb6O13 and non-stoichiometric rutile-type V/Nb/Sb/O; the latter segregated preferentially at the surface of the catalyst. Tin oxide provided the rutile matrix for the dispersion of the mixed oxides. The main role of Sb was shown to generate mixed oxides containing specific sites for the allylic ammoxidation of propylene intermediately formed. The presence of Nb enhanced the activity and selectivity of these sites

The Agile Alert System For Gamma-Ray Transients

In recent years, a new generation of space missions offered great opportunities of discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) onboard the AGILE space mission. The AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many gamma-ray transients of galactic and extragalactic origins. This work presents the AGILE innovative approach to fast gamma-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe: (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for gamma-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, e-mails, and push notifications of an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in gamma-ray astrophysics.Comment: 34 pages, 9 figures, 5 table

On the Angular Resolution of the AGILE gamma-ray imaging detector

We present a study of the Angular Resolution of the AGILE gamma-ray imaging detector (GRID) that is operational in space since April 2007. The AGILE instrument is made of an array of 12 planes each equipped with a Tungsten converter and Silicon micros trip detectors and is sensitive in the energy range 50 MeV - 10 GeV. Among the space instruments devoted to gamma-ray astrophysics, AGILE uniquely exploits an analog readout system with dedicated electronics coupled with Silicon detectors. We show the results of Monte Carlo simulations carried out to reproduce the gamma-ray detection by the GRID, and we compare them to in-flight data. We use the Crab (pulsar + Nebula) system for discussion of real data performance, since its E^{-2} energy spectrum is representative of the majority of gamma-ray sources. For Crab-like spectrum sources, the GRID angular resolution (FWHM of ~4deg at 100 MeV; ~0.8deg at 1 GeV; ~0.9deg integrating the full energy band from 100 MeV to tens of GeV) is stable across a large field of view, being characterized by a flat response up to 30deg off-axis. A comparison of the angular resolution obtained by the two operational gamma-ray instruments, AGILE-GRID and Fermi-LAT, is interesting in view of future gamma-ray missions, that are currently under study. The two instruments exploit different detector configurations affecting the angular resolution: the former being optimized in the readout and track reconstruction especially in the low-energy band, the latter in terms of converter thickness and power consumption. We show that, despite these differences, the angular resolution of both instruments is very similar between 100 MeV and a few GeV.Comment: 19 pages, 8 figures, accepted for publication in Ap