Precision luminosity measurement at ILC

In these proceedings a novel approach to deal with the beam-induced effects in luminosity measurement is presented. Based on the relativistic kinematics of the collision frame of the Bhabha process, the beam-beam related uncertainties can be reduced to the permille level independently of a precision with which the beam parameters are known. Specific event selection combined with the corrective methods we introduce, leads to the systematic uncertainty from the beam-induced effects to be at a few permille level in the peak region above the 80% of the nominal centre-of-mass energies at ILC.Comment: Talk presented on behalf of the FCAL Collaboration at the International Workshop on Future Linear Colliders (LCWS13) Tokyo, Japan, 11-15 November 201

MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia

OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS: The expression level of miR-551b was determined in 50 paraffin-embedded cervical specimens (10 normal squamous epithelium, 18 condylomas, 8 CIN1, and 14 CIN2-3) using quantitative Real-time polymerase chain reaction (qRT-PCR). χ2-test compared miR-551b expression in different diagnosis groups. An Ordered Logistic Regression and a Probit correlation were made to correlate miR-551b expression levels with the cervical tissue histological findings. The immunohistochemical distribution of p16 and Ki-67 according to histopathological findings was also assessed. RESULTS: The distribution of the miR-551b expression profile was significantly lower in CIN1-3 samples compared to other histological diagnosis groups (condyloma and negative). The expression levels were inversely correlated to the cervical pathological grade, from negative to CIN2-3. A 1% increase in miR-551b expression level produced an increase of 19% to the probability of a minor histological grade diagnosis in a range from negative to CIN2-3 and an increase of 13% to the probability of a negative histological grade diagnosis. Among the cases with miR-551b expression < 0.02 (considered as cut-off value) a significant statistical correlation was found between p16 and Ki-67 expression and the diagnosis of CIN2-3. CONCLUSIONS: O ur d ata s howed a s ignificant inverse correlation between miR-551b expression and the histological grading of the lesions, suggesting a tumor suppressive function in the different stages of cervical dysplasia

Energy gap of the bimodal two-dimensional Ising spin glass

An exact algorithm is used to compute the degeneracies of the excited states of the bimodal Ising spin glass in two dimensions. It is found that the specific heat at arbitrary low temperature is not a self-averaging quantity and has a distribution that is neither normal or lognormal. Nevertheless, it is possible to estimate the most likely value and this is found to scale as L^3 T^(-2) exp(-4J/kT), for a L*L lattice. Our analysis also explains, for the first time, why a correlation length \xi ~ exp(2J/kT) is consistent with an energy gap of 2J. Our method allows us to obtain results for up to 10^5 disorder realizations with L <= 64. Distributions of second and third excitations are also shown.Comment: 4 pages, 4 figure

Pointwise consistency of the kriging predictor with known mean and covariance functions

This paper deals with several issues related to the pointwise consistency of the kriging predictor when the mean and the covariance functions are known. These questions are of general importance in the context of computer experiments. The analysis is based on the properties of approximations in reproducing kernel Hilbert spaces. We fix an erroneous claim of Yakowitz and Szidarovszky (J. Multivariate Analysis, 1985) that the kriging predictor is pointwise consistent for all continuous sample paths under some assumptions.Comment: Submitted to mODa9 (the Model-Oriented Data Analysis and Optimum Design Conference), 14th-19th June 2010, Bertinoro, Ital

Domain wall entropy of the bimodal two-dimensional Ising spin glass

We report calculations of the domain wall entropy for the bimodal two-dimensional Ising spin glass in the critical ground state. The L * L system sizes are large with L up to 256. We find that it is possible to fit the variance of the domain wall entropy to a power function of L. However, the quality of the data distributions are unsatisfactory with large L > 96. Consequently, it is not possible to reliably determine the fractal dimension of the domain walls.Comment: 4 pages, 2 figures, submitted to PR

Ion source for tests of ion behavior in the KATRIN beam line

An electron-impact ion source based on photoelectron emission was developed for ionization of gases at pressures below 1e-4 mbar in an axial magnetic field in the order of 5 T. The ion source applies only DC fields, which makes it suitable for use in the presence of equipment sensitive to radio-frequency (RF) fields. The ion source was succesfully tested under varying conditions regarding pressure, magnetic field and magnetic-field gradient, and the results were studied with the help of simulations. The processes in the ion source are well understood and possibilities for further optimization of generated ion currents are clarified.Comment: 10 pages, 13 figure