Neoadjuvant Immune Checkpoint Inhibitors in hepatocellular carcinoma: a meta-analysis and systematic review

BackgroundNeoadjuvant immunotherapy has demonstrated beneficial outcomes in various cancer types; however, standardized protocols for neoadjuvant immunotherapy in hepatocellular carcinoma (HCC) are currently lacking. This systematic review and meta-analysis aims to investigate the reliability of neoadjuvant immunotherapy’s efficacy and safety in the context of HCC.MethodsA systematic search was conducted across PubMed (MEDLINE), EMBASE, the Web of Science, the Cochrane Library, and conference proceedings to identify clinical trials involving resectable HCC and neoadjuvant immunotherapy. Single-arm meta-analyses were employed to compute odds ratios and 95% confidence intervals (CIs). Heterogeneity analysis, data quality assessment, and subgroup analyses based on the type of immunotherapy drugs and combination therapies were performed. This meta-analysis is registered in PROSPERO (identifier CRD42023474276).ResultsThis meta-analysis included 255 patients from 11 studies. Among resectable HCC patients, neoadjuvant immunotherapy exhibited an overall major pathological response (MPR) rate of 0.47 (95% CI 0.31-0.70) and a pathological complete response (pCR) rate of 0.22 (95% CI 0.14-0.36). The overall objective response rate (ORR) was 0.37 (95% CI 0.20-0.69), with a grade 3-4 treatment-related adverse event (TRAE) incidence rate of 0.35 (95% CI 0.24-0.51). Furthermore, the combined surgical resection rate was 3.08 (95% CI 1.66-5.72). Subgroup analysis shows no significant differences in the efficacy and safety of different single-agent immunotherapies; the efficacy of dual ICIs (Immune Checkpoint Inhibitors) combination therapy is superior to targeted combined immunotherapy and monotherapy, while the reverse is observed in terms of safety.DiscussionNeoadjuvant immunotherapy presents beneficial outcomes in the treatment of resectable HCC. However, large-scale, high-quality experiments are warranted in the future to provide robust data support

Reduced-Thickness-Dependent Polarized Light Transmittance of Magnetic Fluids under Longitudinal Magnetic Field

The polarized light transmittance of magnetic fluids under longitudinal magnetic field (parallels the propagation direction of the incident light) is simulated theoretically. The investigated samples are with different reduced thickness (d/λ) in a wide range. Theoretical simulations reveal that the sample reduced thickness has a significant influence on the polarized light transmittance. The thin and thick samples have distinctly different dependence of polarized light transmittance on magnetic field strength. Based on the reduced-thickness- and magnetic-field-dependent polarized light transmittance, several magnetic-fluid-based photonic devices are proposed and discussed

Embankment Project Monitoring Using the Time-Lapse Transient Electromagnetic Method: Numerical Simulation and Field Applications

To preserve flood control infrastructure, it is essential to quickly detect and accurately identify concealed leakage hazards within embankment projects. In this paper, we propose a novel embankment monitoring method based on the time-lapse transient electromagnetic method and complemented by a theoretical framework for analyzing time-lapse data through the lens of resistivity change rates. A time-lapse model that scrutinizes dynamic response patterns associated with leakage anomalies is constructed, while the efficacy of this methodology is verified through rigorous field experiments. Our research findings reveal a well-defined negative correlation between the resistivity variation rate and the development stage of anomalies. Our proposed method demonstrates enhanced sensitivity in the detection of dynamic evolutionary patterns in latent seepage defects, particularly in low-resistivity environments. Moreover, it successfully delineates both the spatial expansions and electrical property alterations of anomalies, providing a novel technical approach for latent seepage defect monitoring and risk management in embankments