Characterization of proteins by means of their buffer capacity, measured with an ISFET-based coulometric sensor-actuator system

Proteins form the specific selector in many biochemical sensors. A change in one of the properties of such a protein has to be detected by an appropriate transducer, which completes the biochemical sensor. One of these properties is the buffer capacity of a protein. If the binding of a substance to a protein can significantly change the proton binding, which accounts for the buffer capacity of proteins, the detection of this changed buffer capacity enables the construction of a new type of biosensor.\ud \ud It will be shown that the buffer capacity can be measured with an ISFET-based sensor—actuator device. The alternating generation of protons and hydroxyl ions by alternating current coulometry at a porous noble metal actuator electrode causes an associated small pH perturbation, which is detected by the underlying pH-sensitive ISFET. The amplitude of the measured signal is a function of the buffer capacity of the solute, in which proteins can be present (or these proteins can be adsorbed in the porous actuator electrode of the device). A model describing the transfer function from the electrical input signal of the actuator to the resulting chemical output, which is subsequently detected by the ISFET pH sensor, is presented. Preliminary results of the measured buffer capacity of ribonuclease and lysozyme are presented

Bilayer graphene as an helical quantum Hall ferromagnet

The two-dimensional electron gas in a bilayer graphene in the Bernal stacking supports a variety of uniform broken-symmetry ground states in Landau level N=0 at integer filling factors $\nu \in [-3,4].$ When an electric potential difference (or bias) is applied between the layers at filling factors $\nu =-1,3$, the ground state evolves from an interlayer coherent state at small bias to a state with orbital coherence at higher bias where \textit{electric} dipoles associated with the orbital pseudospins order spontaneously in the plane of the layers. In this paper, we show that by further increasing the bias at these two filling factors, the two-dimensional electron gas goes first through a Skyrmion crystal state and then into an helical state where the pseudospins rotate in space. The pseudospin textures in both the Skyrmion and helical states are due to the presence of a Dzyaloshinskii-Moriya interaction in the effective pseudospin Hamiltonian when orbital coherence is present in the ground state. We study in detail the electronic structure of the helical and Skyrmion crystal states as well as their collective excitations and then compute their electromagnetic absorption.Comment: 17 pages, 17 postscript figure

Optimizing Hartree-Fock orbitals by the density-matrix renormalization group

We have proposed a density-matrix renormalization group (DMRG) scheme to optimize the one-electron basis states of molecules. It improves significantly the accuracy and efficiency of the DMRG in the study of quantum chemistry or other many-fermion system with nonlocal interactions. For a water molecule, we find that the ground state energy obtained by the DMRG with only 61 optimized orbitals already reaches the accuracy of best quantum Monte Carlo calculation with 92 orbitals.Comment: published version, 4 pages, 4 figure

Novel thick-foam ferroelectret with engineered voids for energy harvesting applications

This work reports a novel thick-foam ferroelectret which is designed and engineered for energy harvesting applications. We fabricated this ferroelectret foam by mixing a chemical blowing agent with a polymer solution, then used heat treatment to activate the agent and create voids in the polymer foam. The dimensions of the foam, the density and size of voids can be well controlled in the fabrication process. Therefore, this ferroelectret can be engineered into optimized structure for energy harvesting applications

A volume inequality for quantum Fisher information and the uncertainty principle

Let $A_1,...,A_N$ be complex self-adjoint matrices and let $\rho$ be a density matrix. The Robertson uncertainty principle $$det(Cov_\rho(A_h,A_j)) \geq det(- \frac{i}{2} Tr(\rho [A_h,A_j]))$$ gives a bound for the quantum generalized covariance in terms of the commutators $[A_h,A_j]$. The right side matrix is antisymmetric and therefore the bound is trivial (equal to zero) in the odd case $N=2m+1$. Let $f$ be an arbitrary normalized symmetric operator monotone function and let $_{\rho,f}$ be the associated quantum Fisher information. In this paper we conjecture the inequality $$det (Cov_\rho(A_h,A_j)) \geq det (\frac{f(0)}{2} _{\rho,f})$$ that gives a non-trivial bound for any natural number $N$ using the commutators $i[\rho, A_h]$. The inequality has been proved in the cases $N=1,2$ by the joint efforts of many authors. In this paper we prove the case N=3 for real matrices

Intruder level and deformation in the SD-pair shell model

The influence of the intruder level on nuclear deformation is studied within the framework of the nucleon-pair shell model truncated to an SD-pair subspace. The results suggest that the intruder level has a tendency to soften the deformation and plays an important role in determining the onset of rotational behavior.Comment: 2 input TeX files, 2 figures, submitted to Phys. Lett.

Fishnet Statistics for Strength Scaling of Nacreous Imbricated Lamellar Materials

Similar to nacre or brick-and-mortar structures, imbricated lamellar structures are widely found in natural and man-made materials and are of interest for biomimetics. These structures are known to be rather insensitive to defects and to have a very high fracture toughness. Their deterministic behavior has been intensely studied, but statistical studies have been rare and is so far there is no undisputed theoretical basis for the probability distribution of strength of nacre. This paper presents a numerical and theoretical study of the PDF of strength and of the corresponding statistical size effect. After a reasonable simplifications of the shear bonds, an axially loaded lamellar shell is statistically modelled as a square fishnet pulled diagonally. A finite element (FE) model is developed and used in Monte Carlo simulations of strength. An analytical model for failure probability of the fishnet is developed and matched to the computed statistical histograms of strength for various sizes. It appears that, with increasing size, the pdf of strength slowly transits from Gaussian to Weilbull distribution but the transition is different from that previously obtained at Northwestern for quasibrittle materials of random heterogeneous mesostructure

CsCl-Type Compounds in Binary Alloys of Rare-Earth Metals with Zinc and Copper

The CsCl-type structure has been previously reported in alloys of copper with yttrium, gadolinium, and erbium, [1] and of zinc with lanthanum, cerium, and praesodymium. [2] The present investigation has uncovered five additional phases in copper-rare-earth alloys and nine in zinc-rare-earth alloys