Search for supersymmetry with a dominant R-parity violating LQDbar couplings in e+e- collisions at centre-of-mass energies of 130GeV to 172 GeV

A search for pair-production of supersymmetric particles under the assumption that R-parity is violated via a dominant LQDbar coupling has been performed using the data collected by ALEPH at centre-of-mass energies of 130-172 GeV. The observed candidate events in the data are in agreement with the Standard Model expectation. This result is translated into lower limits on the masses of charginos, neutralinos, sleptons, sneutrinos and squarks. For instance, for m_0=500 GeV/c^2 and tan(beta)=sqrt(2) charginos with masses smaller than 81 GeV/c^2 and neutralinos with masses smaller than 29 GeV/c^2 are excluded at the 95% confidence level for any generation structure of the LQDbar coupling.Comment: 32 pages, 30 figure

Constraints on anomalous QGC's in e+e−e^{+}e^{-} interactions from 183 to 209 GeV

The acoplanar photon pairs produced in the reaction e(+) e(-) - → vvyy are analysed in the 700 pb(-1) of data collected by the ALEPH detector at centre-of-mass energies between 183 and 209 GeV. No deviation from the Standard Model predictions is seen in any of the distributions examined. The resulting 95% C.L. limits set on anomalous QGCs, a(0)(Z), a(c)(Z), a(0)(W) and a(c)(W), are -0.012 lt a(0)(Z)/Lambda(2) lt +0.019 GeV-2, -0.041 lt a(c)(Z)/Lambda(2) lt +0.044 GeV-2, -0.060 lt a(0)(W)/Lambda(2) lt +0.055 GeV-2, -0.099 lt a(c)(W)/Lambda(2) lt +0.093 GeV-2, where Lambda is the energy scale of the new physics responsible for the anomalous couplings

Measurement of the tau lepton lifetime

The mean lifetime of the tau lepton is measured in a sample of 25700 tau pairs collected in 1992 with the ALEPH detector at LEP. A new analysis of the 1-1 topology events is introduced. In this analysis, the dependence of the impact parameter sum distribution on the daughter track momenta is taken into account, yielding improved precision compared to other impact parameter sum methods. Three other analyses of the one- and three-prong tau decays are updated with increased statistics. The measured lifetime is 293.5+/-3.1+/-1.7 fs. Including previous (1989-1991) ALEPH measurements, the combined tau lifetime is 293.7+/-2.7+/-1.6 fs

Search for charginos nearly mass degenerate with the lightest neutralino in e+e−e^+ e^- collisions at centre-of-mass energies up to 209 GeV

A search for charginos nearly mass degenerate with the lightest neutralino is performed with the data collected by the ALEPH detector at LEP, at centre-of-mass energies between 189 and 209 GeV, corresponding to an integrated luminosity of 628 pb-1. The analysis is based on the detection of isolated and energetic initial state radiation photons, produced in association with chargino pairs whose decay products have little visible energy. The number of candidate events observed is in agreement with that expected from Standard Model background sources. These results are combined with those of other direct searches for charginos, and a lower limit of 88 GeV/c2 at 95 % confidence level is derived for the chargino mass in the case of heavy sfermions, irrespective of the chargino-neutralino mass difference.A search for charginos nearly mass degenerate with the lightest neutralino is performed with the data collected by the ALEPH detector at LEP, at centre-of-mass energies between 189 and 209 GeV, corresponding to an integrated luminosity of 628 pb −1 . The analysis is based on the detection of isolated and energetic initial state radiation photons, produced in association with chargino pairs whose decay products have little visible energy. The number of candidate events observed is in agreement with that expected from Standard Model background sources. These results are combined with those of other direct searches for charginos, and a lower limit of 88 GeV/ c 2 at 95% confidence level is derived for the chargino mass in the case of heavy sfermions, irrespective of the chargino-neutralino mass difference.A search for charginos nearly mass degenerate with the lightest neutralino is performed with the data collected by the ALEPH detector at LEP, at centre-of-mass energies between 189 and 209 GeV, corresponding to an integrated luminosity of 628 pb-1. The analysis is based on the detection of isolated and energetic initial state radiation photons, produced in association with chargino pairs whose decay products have little visible energy. The number of candidate events observed is in agreement with that expected from Standard Model background sources. These results are combined with those of other direct searches for charginos, and a lower limit of 88 GeV/c2 at 95 % confidence level is derived for the chargino mass in the case of heavy sfermions, irrespective of the chargino-neutralino mass difference

Measurement of triple gauge-boson couplings at 172 GeV

The triple gauge-boson couplings, Awp, Aw and Abp, have been measured using 34 semileptonically and 54 hadronically decaying WW candidate events. The events were selected in the data recorded during 1996 with the ALEPH detector at 172 GeV, corresponding to an integrated luminosity of 10.65 pb^-1. The triple gauge-boson couplings have been measured using optimal observables constructed from kinematic information of WW events. The results are in agreement with the Standard Model expectation

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk

An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed of a skeleton of fibrin fibres with cellular elements embedded in this network. Diabetes is characterised by quantitative and qualitative changes in coagulation proteins, which collectively increase resistance to fibrinolysis, consequently augmenting thrombosis risk. Current long-term therapies to prevent arterial occlusion in diabetes are focussed on anti-platelet agents, a strategy that fails to address the contribution of coagulation proteins to the enhanced thrombotic milieu. Moreover, antiplatelet treatment is associated with bleeding complications, particularly with newer agents and more aggressive combination therapies, questioning the safety of this approach. Therefore, to safely control thrombosis risk in diabetes, an alternative approach is required with the fibrin network representing a credible therapeutic target. In the current review, we address diabetes-specific mechanistic pathways responsible for hypofibrinolysis including the role of clot structure, defects in the fibrinolytic system and increased incorporation of anti-fibrinolytic proteins into the clot. Future anti-thrombotic therapeutic options are discussed with special emphasis on the potential advantages of modulating incorporation of the anti-fibrinolytic proteins into fibrin networks. This latter approach carries theoretical advantages, including specificity for diabetes, ability to target a particular protein with a possible favourable risk of bleeding. The development of alternative treatment strategies to better control residual thrombosis risk in diabetes will help to reduce vascular events, which remain the main cause of mortality in this condition