«Національна згода» як об’єкт філософської рефлексії

У статті розглядається концепт «національної згоди» як певний різновид комунікації між владою та громадськістю. Виділяються основні типи соціальної згоди: «згода» як легітимізація влади з боку населення, «згода» як певний різновид ідентичності («національна згода»), «згода» як консенсус стосовно проведення тієї чи іншої політики.The author reviews a concept of «national consent» as a variety of communication between power and community. The basic types of social consent are determined: consent as legitimization of power on the part of society, consent as a definite variety of identity («national consent»), consent as a consensus in politics

Stratification of cumulative antibiograms in hospitals for hospital unit, specimen type, isolate sequence and duration of hospital stay

Background Empirical antibiotic therapy is based on patients' characteristics and antimicrobial susceptibility data. Hospital-wide cumulative antibiograms may not sufficiently support informed decision-making for optimal treatment of hospitalized patients. Methods We studied different approaches to analysing antimicrobial susceptibility rates (SRs) of all diagnostic bacterial isolates collected from patients hospitalized between July 2005 and June 2007 at the University Hospital in Zurich, Switzerland. We compared stratification for unit-specific, specimen type-specific (blood, urinary, respiratory versus all specimens) and isolate sequence-specific (first, follow-up versus all isolates) data with hospital-wide cumulative antibiograms, and studied changes of mean SR during the course of hospitalization. Results A total of 16 281 isolates (7965 first, 1201 follow-up and 7115 repeat isolates) were tested. We found relevant differences in SRs across different hospital departments. Mean SRs of Escherichia coli to ciprofloxacin ranged between 64.5% and 95.1% in various departments, and mean SRs of Pseudomonas aeruginosa to imipenem and meropenem ranged from 54.2% to 100% and 80.4% to 100%, respectively. Compared with hospital cumulative antibiograms, lower SRs were observed in intensive care unit specimens, follow-up isolates and isolates causing nosocomial infections (except for Staphylococcus aureus). Decreasing SRs were observed in first isolates of coagulase-negative staphylococci with increasing interval between hospital admission and specimen collection. Isolates from different anatomical sites showed variations in SRs. Conclusions We recommend the reporting of unit-specific rather than hospital-wide cumulative antibiograms. Decreasing antimicrobial susceptibility during hospitalization and variations in SRs in isolates from different anatomical sites should be taken into account when selecting empirical antibiotic treatmen

Nonlinear Analysis of the Eckhaus Instability: Modulated Amplitude Waves and Phase Chaos with Non-zero Average Phase Gradient

We analyze the Eckhaus instability of plane waves in the one-dimensional complex Ginzburg-Landau equation (CGLE) and describe the nonlinear effects arising in the Eckhaus unstable regime. Modulated amplitude waves (MAWs) are quasi-periodic solutions of the CGLE that emerge near the Eckhaus instability of plane waves and cease to exist due to saddle-node bifurcations (SN). These MAWs can be characterized by their average phase gradient $\nu$ and by the spatial period P of the periodic amplitude modulation. A numerical bifurcation analysis reveals the existence and stability properties of MAWs with arbitrary $\nu$ and P. MAWs are found to be stable for large enough $\nu$ and intermediate values of P. For different parameter values they are unstable to splitting and attractive interaction between subsequent extrema of the amplitude. Defects form from perturbed plane waves for parameter values above the SN of the corresponding MAWs. The break-down of phase chaos with average phase gradient $\nu$ > 0 (``wound-up phase chaos'') is thus related to these SNs. A lower bound for the break-down of wound-up phase chaos is given by the necessary presence of SNs and an upper bound by the absence of the splitting instability of MAWs.Comment: 24 pages, 14 figure

Uptake of 18F-fluorocholine, 18F-fluoro-ethyl- L -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat

Introduction: The positron emission tomography (PET) tracers 18F-fluoro-ethyl-L-tyrosine (FET), 18F-fluorocholine (N,N-dimethyl-N-[18F]fluoromethyl-2-hydroxyethylammonium (FCH]) and 18F-fluoro-2-deoxyglucose (FDG) are used in the diagnosis of brain tumours. The aim of this study was threefold: (a) to assess the uptake of the different tracers in the F98 rat glioma, (b) to evaluate the impact of blood-brain barrier (BBB) disruption and microvessel density (MVD) on tracer uptake and (c) to compare the uptake in the tumours to that in the radiation injuries (induced by proton irradiation of healthy rats) of our previous study. Methods: F98 gliomas were induced in 26 rats. The uptake of FET, FCH and FDG was measured using autoradiography and correlated with histology, disruption of the BBB and MVD. Results: The mean FET, FCH and FDG standardised uptake values (SUVs) in the tumour and the contralateral normal cortex (in parentheses) were 4.19±0.86 (1.32±0.26), 2.98±0.58 (0.51±0.11) and 11.02±3.84 (4.76±1.77) respectively. MVD was significantly correlated only with FCH uptake. There was a trend towards a negative correlation between the degree of BBB disruption and FCH uptake and a trend towards a positive correlation with FET uptake. The ratio of the uptake in tumours to that in the radiation injuries was 1.97 (FCH), 2.71 (FET) and 2.37 (FDG). Conclusion: MVD displayed a significant effect only on FCH uptake. The degree of BBB disruption seems to affect the accumulation of FET and FCH, but not FDG. Mean tumour uptake for all tracers was significantly higher than the accumulation in radiation injurie

Antikaon production in A+A collisions at SIS energies within an off-shell G-matrix approach

The production and propagation of antikaons -- described by dynamical spectral functions $A_h(X,\vec{P},M^2)$ as evaluated from a coupled channel $G$-matrix approach -- is studied for nucleus-nucleus collisions at SIS energies in comparison to the conventional quasi-particle limit and the available experimental data using off-shell transport theory. We find that the $K^-$ spectra for $^{12}C + ^{12}C$ and $^{58}Ni + ^{58}Ni$ at 1.8 A$\cdot$GeV remain underestimated in the $G$-matrix approach as in the on-shell quasi-particle approximation whereas the preliminary spectra for $Au + Au$ at 1.5 A$\cdot$GeV are well described in both limits. This also holds approximately for the $K^-$ rapidity distributions in semi-central collisions of $Ni+Ni$ at 1.93 A$\cdot$GeV. However, in all limits considered there is no convincing description of all spectra simultaneously. Our off-shell transport calculations, furthermore, demonstrate that the strongest in-medium effects should be found for low antikaon momenta in the center-of-mass frame, since the deceleration of the antikaons in the attractive Coulomb and nuclear potentials and the propagation to the on-shell mass induces a net shift and squeezing of the $K^-$ spectra to the low momentum regime.Comment: 44 pages, including 18 eps figures, to be published in Nucl. Phys.

Kaon versus Antikaon Production at SIS Energies

We analyse the production and propagation of kaons and antikaons in Ni + Ni reactions from 0.8--1.85 GeV/u within a coupled channel transport approach including the channels $BB \to K^+YN, \pi B\to K^+Y, BB \to NN K \bar{K}, \pi B\to N K\bar{K}, K^+B\to K^+B, \bar{K} B\to \bar{K}B, Y N\to \bar{K} NN, \pi \pi\to K \bar{K}$ as well as $\pi Y\to \bar{K}N$ and $\bar{K} N\to \pi Y$ for the antikaon absorption. Whereas the experimental $K^+$ spectra can be reproduced without introducing any selfenergies for the mesons in Ni + Ni collisions from 0.8 to 1.8 GeV/u, the $K^-$ yield is underestimated by a factor of 5--7 at 1.66 and 1.85 GeV/u. However, introducing density dependent antikaon masses as proposed by Kaplan and Nelson, the antikaon spectra can be reasonably well described.Comment: 16 pages, LaTeX, plus 12 postscript figures, submitted to Nucl. Phys.

Analysis of Kaon Production at SIS Energies

We analyse the production and propagation of pions and kaons in heavy-ion reactions from 0.8 -- 1.8~A$\cdot$GeV within a coupled channel transport approach including the kaon production channels $BB \to K^+YN, \pi B\to K^+Y, BB \to NN K \bar{K}, \pi B\to N K\bar{K}, K^+B\to K^+B$ and $\pi \pi\to K \bar{K}$. Assuming the hyperon selfenergy to be 2/3 of the nucleon selfenergy we find that all inclusive experimental $K^+$ spectra at SIS energies can be reproduced reasonably well without any selfenergies for the kaons although a slightly repulsive kaon potential cannot be excluded by the present data on kaon spectra and flow.Comment: 19 pages, LaTeX, including 8 postscript figures, to appear in Nucl. Phys.