OCEAN THERMAL ENERGY CONVERSION (OTEC) POWER PLANT AND IT???S BY PRODUCTS YIELD FOR SMALL ISLANDS IN INDONESIA SEA WATER

Small islands in Indonesia sea water are current heavily dependent of fossil fuels.\ud Environmental concerns at global, regional and local levels, past and recent price hikes\ud in the price of oil among others, have been drives behind a regional wide interest in\ud renewable energy technologies. One of the renewable energy resources is the he\ud temperature difference between the upper layer of warm sea water and the bottom layer\ud of cold sea water. As long as the temperature between the warm sea water and cold deep\ud sea water differ by about 18 to 24 OC, an Ocean Thermal Energy (OTEC) system can\ud produce a significant amount of electricity.\ud The sea area in Indonesia region is ideal for OEC power plant to generate electricity\ud for small islands, because the sea area in Indonesia have average monthly temperature\ud difference between 20 to 22 OC of warm sea water surface and colder sea water in the\ud bottom layer. Therefore OTEC is very promoting as an alternative energy source for\ud small islands.\ud OTEC has important benefit other than power production, as by product of OTEC,\ud support chilled soil agriculture, aquaculture, fresh water, mariculture and OTEC power\ud plant is not source of environmental pollution.\ud In this study, we presently propose an OTEC system that utilizes not only thermal\ud energy but also mariculture, chilled soil agriculture, aquaculture, fresh water as by\ud product of OTEC power plant

Epidemiology, presentation, management and outcomes in chronic inflammatory demyelinating polyneuropathy in Birmingham, UK: the impact of ethnicity

Background Whether ethnicity impacts on epidemiology, presentation, management, and outcome is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We studied the prevalence/incidence of CIDP in Asian (Indian/Pakistani/Bangladeshi) and white subjects in Birmingham, UK, and associations of ethnicity with demographics/deprivation/phenotype/treatment and outcomes. Results On 10th July 2025, CIDP prevalence was 6.18 per 100 000 (95% CI: 4.66–8.05). Prevalence was lower in Asian (Indian/Pakistani/Bangladeshi) compared to white subjects (2.64 per 100 000 vs. 10.15 per 100 000; RR: 0.260, 95% CI: 0.111–0.609; p < 0.001). Prevalence in ≥ 50-year-olds was lower in Asian (Indian/Pakistani/Bangladeshi) compared to white subjects (8.00 per 100 000 vs. 46.68 per 100 000; RR: 0.172; 95% CI: 0.061–0.479; p < 0.001) but similar in 18–49-year-olds (2.48 per 100 000 vs. 1.83 per 100 000; RR: 1.355, 95% CI: 0.273–6.712; p = 0.661). Mean incidence of CIDP was 0.54 per 100 000 per year (95% CI: 0.404–0.713). CIDP incidence was lower in Asian (Indian/Pakistani/Bangladeshi) than in white subjects (0.24 per 100 000 per year vs. 0.86 per 100 000 per year, RR: 0.278; 95% CI: 0.118–0.654; p = 0.002). Asian (Indian/Pakistani/Bangladeshi) ethnicity was independently associated with younger age (p = 0.037), greater social deprivation (p = 0.045), and noncompliance to treatment (p = 0.016). No association of Asian (Indian/Pakistani/Bangladeshi) ethnicity was found with CIDP sub-type, diagnostic delay, pretreatment disability, access to high-cost therapies, or posttreatment outcomes. Conclusions Subjects of Asian (Indian/Pakistani/Bangladeshi) ethnicity in the UK may have a lower risk of CIDP after 50 years of age, but an equivalent risk between 18 and 49 years, compared to white subjects. They may present younger, be more socially deprived, and be more likely noncompliant to treatment, compared to white subjects

Catalytic Properties of Luminescent Tris-Homoleptic Cyclometalated Iridium(III) Complexes in the Oxidation of Morin in Visible Light

The photo-oxidation of Morin, 2′,3,4′,5,7-pentahydroxyflavone by six luminescent homoleptic tris-cyclometalated iridium(III) complexes was investigated with the aim of evaluating the catalytic properties of the complexes. The Iridium complexes were synthesized using 2-(1-naphthyl)-pyridine (npy) ligand and its derivatives such as npy-OMe, npy-CF3 and npy-Me to form Tris-homoleptic cyclometalated complexes; Ir(npy)3, Ir(npy-OMe)3, Ir(npy-CF3)3, Ir(npy-Me)3, Ir(Me-npy-Me)3, and Ir(Me-npy)3 with substitution at para position relative to nitrogen. The ligand substitution positions were found to influence the excited state lifetimes, where the complexes exhibited long lifetimes, τ, 1.4 – 3.6 μs, ensuring time for substrates to react before relaxation to ground state. All the six complexes displayed reversible or pseudo reversible redox processes with ground state oxidation potential range of 0.57 to 0.93V compared to Standard Calomel Electrode in CH2Cl2. The complexes degraded morin with rate constants kobs between 0.023-0.036 s -1 within a timescale of 12 minutes. The Ir(npy-Me)3 complex was found to have a high degradation with a rate constant of kobs = 0.036 s -1. Degradation reactions using all the six Iridium (III) complexes photoredox catalysts were found to follow first order kinetics and ca. 10-fold faster compared to similar oxidative reactions

Biotechnology in Veterinary Medicine

In various areas of medicine biotechnology is consider as already established approach, but to revolutionize veterinary practice with the potential in veterinary medicine field it has only begun to emerge. For animal breeding and veterinary medicine it has proposed new dimensions with the continuous growth of modern biotechnology. To discard any possible genetic disorder i t ultimately permits to consequently and detect through genome analysis of important breeding species. It can also detect more reliably and easily the infectious diseases. With improved productivity and health it opens the possibility to generate animals with the production of transgenic livestock and it introduced a less time taking program of breeding

Impact of social deprivation on diagnosis, management and outcome of chronic inflammatory demyelinating polyneuropathy at a tertiary U.K. centre

BACKGROUND: Whether social deprivation may affect diagnosis, management, and outcomes of subjects with chronic inflammatory demyelinating polyneuropathy (CIDP) is unknown. METHODS: We conducted a retrospective study of subjects with CIDP attending University Hospitals Birmingham, UK. Demographics, clinical characteristics, treatment data, post-treatment outcomes and Index of Multiple Deprivation 2019 were collected. Postcodes were categorised in local vs. non-local and travelling distances to the hospital were ascertained. RESULTS: We included 155 consecutive subjects with CIDP. Mean age was 62.2 years (SD: 15.1). Male to female ratio was 1.67:1. One-hundred and eighteen subjects (76.1%) had typical CIDP. Greater pre-treatment disability was independently associated with greater social deprivation (p = 0.031) and longer pre-treatment disease duration (p = 0.001). Neither use of high-cost first-line therapies, nor immunosuppressant usage, were associated with social deprivation. Post-treatment outcomes were not associated with social deprivation. Greater social deprivation was independently associated with younger age (p = 0.002), having a local post-code (p = 0.001) and living closer to the hospital (p < 0.001). Subjects from the two most socially deprived deciles were younger (p = 0.025) and more disabled pre-treatment (p = 0.028) than those from the two least deprived deciles. Significantly fewer tertiary referrals were received for the two most socially deprived deciles compared to the two least deprived deciles (9.9% vs. 31.3%; p = 0.001). CONCLUSIONS: Despite a publicly funded healthcare system with universal access, social deprivation independently contributed to greater pre-treatment disability in subjects with CIDP in this UK cohort. Social deprivation did not impact on treatments administered and post-treatment outcomes but may have influenced tertiary referral decisions to our centre

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

The combined effect of learning model and teaching style spectrum on student satisfaction in Physical Education learning

Introduction: Student satisfaction in physical education is achieved when teachers apply appropriate teaching approaches that meet student needs. Objective: This study explored student satisfaction through two innovative models, teaching games for understanding and project-based learning, with productive and reproductive teaching styles. Methodology: A quasi-experimental design with five groups was employed, involving 81 elementary school students aged 12–13 years from four schools in Salatiga. Data were collected using a pretest and a posttest with a sports satisfaction instrument, and analyzed using ANOVA. Results: The results showed that teaching games for understanding with a reproductive style (p = 0.006) and productive style (p = 0.041) significantly increased student satisfaction. Similarly, project-based learning with a reproductive style (p = 0.031) and productive style (p = 0.002) also had a positive effect, while conventional learning methods did not show a significant increase (p = 0.12). Among the tested approaches, project-based learning with a reproductive style had the most substantial impact on student satisfaction, followed by teaching games for understanding with a productive style. Discussion: These findings indicate that combining teaching games for understanding and project-based learning with different spectrum teaching styles can foster student autonomy, creativity, and social interaction. Such approaches enhance intrinsic motivation, self-confidence, and engagement in learning, offering more meaningful experiences than conventional teacher-centered methods. Conclusions: student-centered pedagogical models in physical education are more effective in promoting satisfaction, and project-based learning with a reproductive style emerged as the most influential approach

Sub Proposal Program Penguatan Kapasitas Organisasi Kemahasiswaan (Ppk Ormawa) Optimalisasi Pelayanan Kesehatan Desa Potronayan Dalam Peningkatan Gizi Guna Membangun Healthy Village Dan Mencegah Stunting

Desa Potronayan terdiri dari 250 KK dengan jumlah penduduk total sebanyak 7.000 jiwa, mayoritas penduduk berumur 17 tahun ke atas yaitu berjumlah 5.000 jiwa. Kurangnya pengetahuan terkait kesehatan karena tidak terdapatnya layanan kesehatan yang mewadahi, maka dari hal tersebut mengakibatkan masalah kesehatan menjadi salah satu isu yang menjadi perhatian khusus. Metode yang digunakan dengan survei secara langsung, transect walk, observasi, FGD serta wawancara bersama dengan pemerintah desa maupun tokoh masyarakat. Dengan masalah tersebut maka pengambilan solusi dilakukan seperti membentuk bank sampah dan memanfaatkan sampah rumah tangga, membuat modul “Desa Potronayan Sehat” sebagai rujukan GERMAS dan pencegahan stunting, memulai gerakan keluarga sadar gizi dengan melakukan pelatihan pengolahan bahan pangan bergizi. Luaran wajib yang ditargetkan oleh tim PPK Ormawa PRISMA UMS, yaitu buku refleksi ormawa dalam pemberdayaan desa, ringkasan eksekutif, media publikasi elektronik berupa video pelaksanaan PPK Ormawa yang diunggah di YouTube UMS dan YouTube PRISMA UMS yang dapat diakses publik, poster dan profil hasil pelaksanaan program PPK Ormawa

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.</p

Genetic Risk Score for Intracranial Aneurysms:Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

BACKGROUND: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. METHODS: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. RESULTS: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20-1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01-1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59-0.67) to 0.65 (95% CI, 0.62-0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=-4.82×10(-3) per year [95% CI, -6.49×10(-3) to -3.14×10(-3)]; P=1.82×10(-8)), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86-0.98]; P=0.0041). CONCLUSIONS: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH