791 research outputs found

    The Buenos Aires water concession

    Get PDF
    The signing of a concession contract for the Buenos Aires water and sanitation system in December 1992, attracted worldwide attention, and caused considerable controversy in Argentina. It was one of the world's largest concessions, but the case was also interesting for other reasons. The concession was implemented rapidly, in contrast with slow implementation of privatization in Santiago, for example. And reform generated major improvements in the sector, including wider coverage, better service, more efficient company operations, and reduced waste. Moreover, the winning bid brought an immediate 26.9 percent reduction in water system tariffs. Consumers benefited from the system's expansion and from the immediate drop in real prices, which was only partly reversed by subsequent changes in tariffs, and access charges. And these improvements would probably not have occurred under public administration of the system. Still, the authors show information asymmetries, perverse incentives, and weak regulatory institutions could threaten the concession's sustainability. Opportunities for the company to act opportunistically - and the regulator, arbitrarily - exist, because of politicized regulation, a poor information base, serious flaws in the concession contract, a lumpy and ad hoc tariff system, and a general lack of transparency in the regulatory process. Because of these circumstances, public confidence in the process has eroded. The Buenos Aires concession shows how important transparent, rule-based decision-making is to maintain public trust in regulated infrastructure.Health Economics&Finance,Environmental Economics&Policies,Water Conservation,Water and Industry,Decentralization,Town Water Supply and Sanitation,Environmental Economics&Policies,Water and Industry,Water Supply and Sanitation Governance and Institutions,Water Conservation

    Some aspects of the synchronization in coupled maps

    Full text link
    Through numerical simulations we analyze the synchronization time and the Lyapunov dimension of a coupled map lattice consisting of a chain of chaotic logistic maps exhibiting power law interactions. From the observed behaviors we find a lower bound for the size NN of the lattice, independent of the range and strength of the interaction, which imposes a practical lower bound in numerical simulations for the system to be considered in the thermodynamic limit. We also observe the existence of a strong correlation between the averaged synchronization time and the Lyapunov dimension. This is an interesting result because it allows an analytical estimation of the synchronization time, which otherwise requires numerical simulations.Comment: 4 pages, 6 figure

    Deficiency of GABAergic synaptic inhibition in the Kölliker-Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome

    Get PDF
    Life threatening breathing irregularity and central apnoeas are highly prevalent in children suffering from Rett syndrome. Abnormalities in inhibitory synaptic transmission have been associated with the physiopathology of this syndrome, and may underlie the respiratory disorder. In a mouse model of Rett syndrome, GABAergic terminal projections are markedly reduced in the Kölliker–Fuse nucleus (KF) in the dorsolateral pons, an important centre for control of respiratory rhythm regularity. Administration of a drug that augments endogenous GABA localized to this region of the pons reduced the incidence of apnoea and the respiratory irregularity of Rett female mice. Conversely, the respiratory disorder was recapitulated by blocking GABAergic transmission in the KF area of healthy rats. This study helps us understand the mechanism for generation of respiratory abnormality in Rett syndrome, pinpoints a brain site responsible and provides a clear anatomical target for the development of a translatable drug treatment

    MODELO EXPERIMENTAL DE GLOMERULONEFRITIS MEMBRANOSA INDUCIDA CON ALBUMINA BOVINA

    Get PDF
    El objetivo del presente trabajo fue diseñar un modelo experimental de Glomerulonefritis Membranosa (GM) en ratas Wistar, inducida con Seroalbúmina Bovina (BSA), y validarlo mediante la determinación de parámetros bioquímicos, histológicos, ultraestructurales y detección de inmunocomplejos por inmunofluorescencia (IF). Los animales del grupo experimental fueron inmunizados por vía subcutánea, con dosis de 3 mg c/u de BSA/PBS con adyuvante de Freund. Se efectuaron diferentes esquemas de inmunización. Cuando el título de anticuerpos fue ≥1/2, comenzó la administración diaria de 2 mg, por vía endovenosa de BSA/PBS, durante 15 días. Se evaluó la funcionalidad renal por la proteinuria; después de la 5° semana, desde su aparición, se determinó: depuración (clearance) de creatinina, uremia, proteinemia y perfil lipídico. Los dos riñones se usaron para estudios histológicos, ultraestructurales y detección de inmunocomplejos por IF. Los resultados mostraron que la inmunización fue efectiva con 5 R E S U M E N inoculaciones c/15 días. En los animales nefróticos la proteinuria, depuración (clearance) de creatinina, proteinemia , uremia y el perfil lipídico presentaron alteraciones significativas (p<0.0001). Al microscopio óptico se observó hipercelularidad, engrosamiento difuso de las membranas basales de los capilares glomerulares y diferentes grados de atrofia, esclerosis e hialinización de los glomérulos. Por IF se detectó inmunocomplejos IgG en el 100 % de los glomérulos. Ultraestructuralmente, se observaron depósitos subepiteliales electrodensos en la membrana basal engrosada, compatibles con inmunocomplejos . Se encontraron alteraciones en la estructura de los podocitos. En conclusión, los estudios bioquímicos, estructurales y ultraestructurales permitieron inferir la inducción de un síndrome nefrótico experimental. Concluimos que el protocolo utilizado tiene validez para la inducción de una glomerulonefritis membranosa en ratas Wistar

    Balanço hidrológico da microbacia do córrego lageado, Município de Uberaba-MG, para o ano de 2012.

    Get PDF
    O manejo integrado em microbacia hidrográfica implementa uma nova maneira de se planejar e usar os recursos naturais, indo de encontro ao desenvolvimento sustentável. A compreensão do balanço hídrico, mesmo que de forma simplificada, é importante para o entendimento dos processos de degradação e conservação dos recursos naturais relacionados ao uso do solo e da água. Dentro deste contexto, o presente estudo teve por objetivo fazer o balanço hídrico da microbacia do córrego Lageado, situada no município de Uberaba, MG, para o ano de 2012. A escolha desta microbacia para este trabalho baseou-se na sua importância como terceiro maior manancial pertencente à APA (Área de Proteção Ambiental) do rio Uberaba e por estar parcialmente dentro do perímetro urbano. Nas últimas décadas, esta microbacia hidrográfica passou por intensas transformações relacionadas ao uso e à ocupação do solo

    Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections

    Get PDF
    During the past year, a group has argued that unsafe injections are a major if not the main mode of HIV-1 transmission\ud in sub-Saharan Africa. We review the main arguments used to question the epidemiological interpretations on the lead\ud role of unsafe sex in HIV-1 transmission, and conclude there is no compelling evidence that unsafe injections are a\ud predominant mode of HIV-1 transmission in sub-Saharan Africa. Conversely, though there is a clear need to eliminate\ud all unsafe injections, epidemiological evidence indicates that sexual transmission continues to be by far the major\ud mode of spread of HIV-1 in the region. Increased efforts are needed to reduce sexual transmission of HIV-1
    corecore