Another factor to consider in choosing a child support guideline: Errors in child support calculations

In an effort to standardize the calculation of monthly child support awards, the federal government requires states to use preestablished formulas to determine the amount of awards. However, because of human error, differences in the experience and training of the officials making the calculations, and the extent to which computers are used to calculate the awards, the formulas do not always yield the same result. In fact, the discrepancy between the amount calculated by an individual child support official and the approved amount as calculated by the state in which that official works can be quite large, on the order of several hundred dollars. Adopting simpler formulas will reduce errors; this should be a priority even if child support officials use computers to calculate award amounts (computers can reduce errors but will not eliminate them, particularly in the case of complex formulas). Efforts to further the training and education of personnel who calculate awards would also help, and child support offices should revise their formulas to cover high-income cases.

Child support enforcement for teenage fathers: Problems and prospects

The NLSY data indicate that about 7.3 percent of teenage males become fathers and that very few of these fathers live with their children. Father absence and the concurrent increase in female-headed households are closely associated with the impoverishment of children. Most absent teen fathers never come into contact with the child support enforcement program, and the extent to which they financially support their children informally is not well understood. While the income of absent teen fathers is low in the teen years, it increases over time, as does the potential for collecting child support. Nevertheless, men who were absent teen fathers earn less in early adulthood than men who deferred parenting until age twenty or later and teen fathers who lived with their children. Early establishment of paternity and greater standardization in the treatment of adolescent fathers by the child support enforcement program are recommended. Further, the substantial and persistent income deficit experienced by adolescent fathers who live apart from their children raises an interesting dilemma. While children may benefit financially and psychosocially from living with two parents, the lower income of men who were absent teenage fathers may make them poor marital prospects. This raises doubts about the recent recommendations of some scholars that we should bring back the shotgun wedding.

A preliminary investigation of materialism and impulsiveness as predictors of technological addictions among young adults

Background and aims: The primary objective of the present research is to investigate the drivers of technological addiction in college students — heavy users of Information and Communication Technology (ICT). The study places cell phone and instant messaging addiction in the broader context of consumption pathologies, investigating the influence of materialism and impulsiveness on these two technologies. Clearly, cell phones serve more than just a utilitarian purpose. Cell phones are used in public and play a vital role in the lives of young adults. The accessibility of new technologies, like cell phones, which have the advantages of portability and an ever increasing array of functions, makes their over-use increasingly likely. Methods: College undergraduates (N = 191) from two U.S. universities completed a paper and pencil survey instrument during class. The questionnaire took approximately 15–20 minutes to complete and contained scales that measured materialism, impulsiveness, and mobile phone and instant messaging addiction. Results: Factor analysis supported the discriminant validity of Ehrenberg, Juckes, White and Walsh's (2008) Mobile Phone and Instant Messaging Addictive Tendencies Scale. The path model indicates that both materialism and impulsiveness impact the two addictive tendencies, and that materialism's direct impact on these addictions has a noticeably larger effect on cell phone use than instant messaging. Conclusions: The present study finds that materialism and impulsiveness drive both a dependence on cell phones and instant messaging. As Griffiths (2012) rightly warns, however, researchers must be aware that one's addiction may not simply be to the cell phone, but to a particular activity or function of the cell phone. The emergence of multi-function smart phones requires that research must dig beneath the technology being used to the activities that draw the user to the particular technology

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising the anal glandular neoplasms at the histologic, immunologic, genomic and epidemiologic levels. In this multi-institutional study, we first examined the histological features displayed by each collected tumour (n = 74) and analysed their etiological relationship with human papillomavirus (HPV) infection. The intratumoural immune cell subsets (CD4, CD8, Foxp3), the expression of immune checkpoints (PD-1, PD-L1), the defect in mismatch repair proteins and the mutation analysis of multiple clinically relevant genes in the gastrointestinal cancer setting were also determined. Finally, the prognostic significance of each clinicopathological variable was assessed. Phenotypic analysis revealed two region-specific subtypes of anal canal adenocarcinoma. The significant differences in the HPV status, density of tumour-infiltrating lymphocytes, expression of immune checkpoints and mutational profile of several targetable genes further supported the separation of these latter neoplasms into two distinct entities. Importantly, anal gland/transitional-type cancers, which poorly respond to standard treatments, displayed less mutations in downstream effectors of the EGFR signalling pathway (i.e., KRAS and NRAS) and demonstrated a significantly higher expression of the immune inhibitory ligand-receptor pair PD-1/PD-L1 compared to their counterparts arising from the colorectal mucosa. Taken together, the findings reported in the present article reveal, for the first time, that glandular neoplasms of the anal canal arise by HPV-dependent or independent pathways. These etiological differences leads to both individual immune profiles and mutational landscapes that can be targeted for therapeutic benefits

Considerations for reducing food system energy demand while scaling up urban agriculture

There is an increasing global interest in scaling up urban agriculture (UA) in its various forms, from private gardens to sophisticated commercial operations. Much of this interest is in the spirit of environmental protection, with reduced waste and transportation energy highlighted as some of the proposed benefits of UA; however, explicit consideration of energy and resource requirements needs to be made in order to realize these anticipated environmental benefits. A literature review is undertaken here to provide new insight into the energy implications of scaling up UA in cities in high-income countries, considering UA classification, direct/indirect energy pressures, and interactions with other components of the food–energy–water nexus. This is followed by an exploration of ways in which these cities can plan for the exploitation of waste flows for resource-efficient UA. Given that it is estimated that the food system contributes nearly 15% of total US energy demand, optimization of resource use in food production, distribution, consumption, and waste systems may have a significant energy impact. There are limited data available that quantify resource demand implications directly associated with UA systems, highlighting that the literature is not yet sufficiently robust to make universal claims on benefits. This letter explores energy demand from conventional resource inputs, various production systems, water/energy trade-offs, alternative irrigation, packaging materials, and transportation/supply chains to shed light on UA-focused research needs. By analyzing data and cases from the existing literature, we propose that gains in energy efficiency could be realized through the co-location of UA operations with waste streams (e.g. heat, CO2, greywater, wastewater, compost), potentially increasing yields and offsetting life cycle energy demands relative to conventional approaches. This begs a number of energy-focused UA research questions that explore the opportunities for integrating the variety of UA structures and technologies, so that they are better able to exploit these urban waste flows and achieve whole-system reductions in energy demand. Any planning approach to implement these must, as always, assess how context will influence the viability and value added from the promotion of UA

CRELD2 Is a Novel LRP1 Chaperone That Regulates Noncanonical WNT Signaling in Skeletal Development

Cysteine-rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER)-resident chaperone highly activated under ER stress in conditions such as chondrodysplasias; however, its role in healthy skeletal development is unknown. We show for the first time that cartilage-specific deletion of Creld2 results in disrupted endochondral ossification and short limbed dwarfism, whereas deletion of Creld2 in bone results in osteopenia, with a low bone density and altered trabecular architecture. Our study provides the first evidence that CRELD2 promotes the differentiation and maturation of skeletal cells by modulating noncanonical WNT4 signaling regulated by p38 MAPK. Furthermore, we show that CRELD2 is a novel chaperone for the receptor low-density lipoprotein receptor-related protein 1 (LRP1), promoting its transport to the cell surface, and that LRP1 directly regulates WNT4 expression in chondrocytes through TGF-β1 signaling. Therefore, our data provide a novel link between an ER-resident chaperone and the essential WNT signaling pathways active during skeletal differentiation that could be applicable in other WNT-responsive tissues. © 2020 American Society for Bone and Mineral Research. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research

Enhanced Synthesis of the Exopolysaccharide Ethapolan by Acinetobacter sp. 12S Grown on a Mixture of Substrates

Earlier, we found that the synthesis of the microbial exopolysaccharide (EPS) ethapolan by Acinetobacter sp. 12S can be enhanced by growing this bacterium on a mixture of ethanol and glucose It should be noted that the cultivation of Acinetobacter sp. 12S on the substrate mixture was accompanied by the enhancement of the synthesis of not only the EPS but also the biomass. The aim of this work was to maximize the transformation of the substrate carbon into EPS. Among the factors studied that may influence the transformation efficiency were the effect of the inoculum, the concentration of carbon and nitrogen sources in the medium, the nature of the energy-deficient substrate, and the availability of sodium ions. MATERIALS AND METHODS Strains. The two bacterial strains used in this work were Acinetobacter sp. 12S (the ethapolan producer described earlier Cultivation conditions. The strains were grown in a liquid mineral medium Cells for inoculation were grown on nutrient agar for 2 days or in mineral K + medium with (a) 0.5 vol % ethanol, (b) 0.5 wt % glucose, or (c) 0.5 vol % ethanol + 0.5 wt % glucose for 16-24 h (i.e., to the exponential growth phase). The inoculum was grown at the Abstract -Enhanced synthesis of the exopolysaccharide ethapolan by Acinetobacter sp. 12S was observed when the bacterium was grown on a mixture of two energetically nonequivalent substrates (ethanol and glucose) taken in a molar proportion of 3.1 : 1. The efficiency of carbon transformation into EPSs was maximum when sodium ions were absent in the medium, the concentration of nitrogen source was reduced to 0.3-0.45 g/l, and the inoculum was grown on ethanol. Such conditions provided an increase in the maximum specific growth rate and its attainment in earlier cultivation terms. Molasses as a substitution for glucose was inefficient. The activities of the key enzymes of C 2 metabolism in Acinetobacter sp. 12S cells grown on the substrate mixture were 1.1 to 1.7 times lower than they were during growth on ethanol alone. The activity of isocitrate lyase in cells grown on the substrate mixture declined to an even greater extent (by 4-7 times), indicating that the role of the glyoxylate cycle in such cells is insignificant. Key words : intensification of exopolysaccharide synthesis, mixed substrate, key enzymes of C 2 and C 6 metabolism