Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines

We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that proton bonding can block some non radiative processes present in the monomer.Comment: We acknowledge the use of the computing facility cluster GMPCS of the LUMAT federation (FR LUMAT 2764

Power management and control strategies for off-grid hybrid power systems with renewable energies and storage

This document is the Accepted Manuscript of the following article: Belkacem Belabbas, Tayeb Allaoui, Mohamed Tadjine, and Mouloud Denai, 'Power management and control strategies for off-grid hybrid power systems with renewable energies and storage', Energy Systems, September 2017. Under embargo. Embargo end date: 19 September 2018. The final publication is available at Springer via https://doi.org/10.1007/s12667-017-0251-y.This paper presents a simulation study of standalone hybrid Distributed Generation Systems (DGS) with Battery Energy Storage System (BESS). The DGS consists of Photovoltaic (PV) panels as Renewable Power Source (RPS), a Diesel Generator (DG) for power buck-up and a BESS to accommodate the surplus of energy, which may be employed in times of poor PV generation. While off-grid DGS represent an efficient and cost-effective energy supply solution particularly to rural and remote areas, fluctuations in voltage and frequency due to load variations, weather conditions (temperature, irradiation) and transmission line short-circuits are major challenges. The paper suggests a hierarchical Power Management (PM) and controller structure to improve the reliability and efficiency of the hybrid DGS. The first layer of the overall control scheme includes a Fuzzy Logic Controller (FLC) to adjust the voltage and frequency at the Point of Common Coupling (PCC) and a Clamping Bridge Circuit (CBC) which regulates the DC bus voltage. A maximum power point tracking (MPPT) controller based on FLC is designed to extract the optimum power from the PV. The second control layer coordinates among PV, DG and BESS to ensure reliable and efficient power supply to the load. MATLAB Simulink is used to implement the overall model of the off-grid DGS and to test the performance of the proposed control scheme which is evaluated in a series of simulations scenarios. The results demonstrated the good performance of the proposed control scheme and effective coordination between the DGS for all the simulation scenarios considered.Peer reviewedFinal Accepted Versio

Evaluación del grado de depresión de adultos mayores de 60 años del AA.HH “Viña alta” – La Molina, Lima-Perú.

OBJETIVODeterminar la prevalencia de depresión en Adultos Mayores de 60 años residentes en el Asentamiento Humano de “Viña Alta” de La Molina, durante el mes de Junio del 2010.MATERIAL Y MÉTODOEstudio de corte transversal tipo entrevista de carácter descriptivo, realizado durante la primera semana de Junio del 2010. Se realizaron visitas en todas las casas (280) de 18 de las 23 manzanas del asentamiento humano “Viña Alta” en la Molina. Se identificó a 112 adultos mayores de 60 años y se entrevistó a 68 de ellos, quienes fueron evaluados por los investigadores (previo entrenamiento) mediante la Escala de depresión geriátrica de Yesavage de 15 ítems (GDS-15).RESULTADOSLa edad media fue de 67,82 años (60-83) 53.3% fueron mujeres; el 51.67% presentó depresión en algún grado según el GDS-15; 33,3% eran analfabetos; y 70%, casados. Al contrastar los resultados del grado de depresión se verificó que no existían diferencias significativas en cuanto a género, grado de instrucción, edad y estado civil.CONCLUSIONESSe identificó una alta prevalencia de depresión (51.67%) que no estuvo asociada a ninguna de las variables del estudio

Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring

Folate is an essential vitamin for vertebrate embryo development. Methotrexate (MTX) is a folate antagonist that is widely prescribed for autoimmune diseases, blood and solid organ malignancies, and dermatologic diseases. Although it is highly contraindicated for pregnant women, because it is associated with an increased risk of multiple birth defects, the effect of paternal MTX exposure on their offspring has been largely unexplored. Here, we found MTX treatment of adult medaka male fish (Oryzias latipes) causes cranial cartilage defects in their offspring. Small non-coding RNA (sncRNAs) sequencing in the sperm of MTX treated males identify differential expression of a subset of tRNAs, with higher abundance for specific 5′ tRNA halves. Sperm RNA methylation analysis on MTX treated males shows that m5C is the most abundant and differential modification found in RNAs ranging in size from 50 to 90 nucleotides, predominantly tRNAs, and that it correlates with greater testicular Dnmt2 methyltransferase expression. Injection of sperm small RNA fractions from MTX-treated males into normal fertilized eggs generated cranial cartilage defects in the offspring. Overall, our data suggest that paternal MTX exposure alters sperm sncRNAs expression and modifications that may contribute to developmental defects in their offspring.CSIC: I+D_2020_43

Innovative modelling approach for the work piece whirling motion in the lathe machine

AbstractAn innovative modeling approach to study the whirling motion of the lathe machine in the intermediate turning stage is presented by introducing the system excitation in the form of cutting forces between the cutting edge head and the workpiece. This involves nonhomogeneous boundary conditions with homogeneous equations. The mathematical modeling approach enabled us to solve the problem by modal analysis by transforming the problem into nonhomogeneous equations with homogenous boundary conditions. The proposed approach enables us to predict the whirling motion at different locations on the cutting edge-workpiece system