790 research outputs found

    Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival

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    Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited. We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis. Patients and Methods: Tissue samples were obtained from surgically treated patients. Expression of the EC-cell marker, vesicular monoamine transporter-1 (VMAT-1), was used to verify ileal carcinoids. We investigated the differential expression of MMP-2, 7, 9, 11, and 13 and their endogenous inhibitors (TIMP-1, 2, and 3) by quantitative real-time RT-PCR in 25 primary tumors, their corresponding lymph node metastases and/or liver metastases and matched normal mucosa. Results: Significantly increased expression of VMAT-1, MMP-2, MMP-11, TIMP-1 and TIMP-3 was determined by quantitative RT-PCR in EC-cell carcinoids compared to normal intestinal mucosa (p < 0.05). In contrast, MMP-2 and MMP-9 as well as TIMP-1, TIMP-2, and TIMP-3 expression in primary tumors of patients with liver metastases (M1) was significantly lower than in patients lacking liver metastases (M0). EC-cell tumors were significantly larger in the M1 group of tumors, while VMAT-1 expression was significantly decreased. We found an inverse correlation between tumor size and prognosis. Univariate analysis further revealed that decreased expression of VMAT-1, MMP-2 and TIMP-3 in primary tumors was significantly associated with a reduced survival time of the patients. Conclusion: Our data reveal that MMP-2 and TIMP-3 expression together with VMAT-1 expression are of potential prognostic and clinical value in ileal carcinoids. Copyright (C) 2008 S. Karger AG, Base

    Zero Temperature Thermodynamics of Asymmetric Fermi Gases at Unitarity

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    The equation of state of a dilute two-component asymmetric Fermi gas at unitarity is subject to strong constraints, which affect the spatial density profiles in atomic traps. These constraints require the existence of at least one non-trivial partially polarized (asymmetric) phase. We determine the relation between the structure of the spatial density profiles and the T=0 equation of state, based on the most accurate theoretical predictions available. We also show how the equation of state can be determined from experimental observations.Comment: 10 pages and 7 figures. (Minor changes to correspond with published version.

    Spin 1/2 Fermions in the Unitary Regime: A Superfluid of a New Type

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    We have studied, in a fully non-perturbative calculation, a dilute system of spin 1/2 interacting fermions, characterized by an infinite scattering length at finite temperatures. Various thermodynamic properties and the condensate fraction were calculated and we have also determined the critical temperature for the superfluid-normal phase transition in this regime. The thermodynamic behavior appears as a rather surprising and unexpected melange of fermionic and bosonic features. The thermal response of a spin 1/2 fermion at the BCS-BEC crossover should be classified as that of a new type of superfluid.Comment: 4 pages, 1 figure, published versio

    Thermodynamics of a Trapped Unitary Fermi Gas

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    We present the first model-independent comparison of recent measurements of the entropy and of the critical temperature of a unitary Fermi gas, performed by Luo et al., with the most complete results currently available from finite temperature Monte Carlo calculations. The measurement of the critical temperature in a cold fermionic atomic cloud is consistent with a value Tc=0.23(2)epsilonFT_c=0.23(2)epsilon_F in the bulk, as predicted by the present authors in their Monte Carlo calculations.Comment: 5 pages, 4 figures, published versio

    Induced P-wave Superfluidity in Asymmetric Fermi Gases

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    We show that two new intra-species P-wave superfluid phases appear in two-component asymmetric Fermi systems with short-range S-wave interactions. In the BEC limit, phonons of the molecular BEC induce P-wave superfluidity in the excess fermions. In the BCS limit, density fluctuations induce P-wave superfluidity in both the majority and the minority species. These phases may be realized in experiments with spin-polarized Fermi gases.Comment: published versio

    On the specific heat of a fermionic atomic cloud in the unitary regime

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    In the unitary regime, when the scattering amplitude greatly exceeds in magnitude the average inter-particle separation, and below the critical temperature thermal properties of an atomic fermionic cloud are governed by the collective modes, specifically the Bogoliubov-Anderson sound modes. The specific heat of an atomic cloud in a elongated trap in particular has a rather compex temperature dependence, which changes from an exponential behavior at very low temperatures (TωT\ll\hbar\omega_{||}), to T\propto T for ωTω\hbar\omega_{||}\ll T \ll \hbar\omega_\perp and then continuosly to T4\propto T^4 at temperatures just below the critical temperature, when the surface modes play a dominant role. Only the low (ωTω\hbar\omega_{||} \ll T \ll \hbar\omega_\perp) and high (ωT<Tc\hbar\omega_\perp \ll T < T_c) temperature power laws are well defined. For the intermediate temperatures one can introduce at most a gradually increasing with temperature exponent.Comment: 4 page

    The Vortex State in a Strongly Coupled Dilute Atomic Fermionic Superfluid

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    We show that in a dilute Fermionic superfluid, when the Fermions interact with an infinite scattering length, a vortex state is characterized by a strong density depletion along the vortex core. This feature can make a direct visualization of vortices in Fermionic superfluids possible.Comment: 4 pages, 3 figures, published version, some small changes and new and updated reference
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