Modern contraceptive methods knowledge and practice among blind and deaf women in Ethiopia. A cross-sectional survey

Abstract Background Evidences from various parts of the world reveal that women with disabilities are facing widespread barriers in accessing public services. Service providers and program managers do not grasp the relevance of their work and interventions in addressing the sexual and reproductive health needs of women with disabilities. The present study therefore aimed to assess family planning knowledge and practice among women with sensory disabilities. Methods A mixed method approach using quantitative and qualitative methods was employed to collect the data. The study included 326 blind and deaf women using respondent driven sampling technique and 29 purposely selected key informants. We carried out the study from August 2016–April 2017. The quantitative data were analyzed using SPSS and the qualitative analysis was done using Open code software version 4.02 and triangulated with the quantitative findings. Results The findings showed that nearly two third of the respondents of were sexually active. The majority (97.2%) of study respondents had heard about FP methods, however the level of comprehensive knowledge on modern contraceptive methods was 32.5%. The prevalence of unwanted pregnancy was 67.0% and abortion was 44%. Almost half of sexually active respondents ever used modern contraceptive methods, yet the contraceptive prevalence at the time of survey was 31.1%. Implants were the most commonly used (51%) contraceptive method among current users. Conclusions The use of modern contraceptive methods among women with sensory disabilities was low. Thus, the government and concerned organizations need to address the attitudinal, social, and physical barriers women with sensory disabilities are facing while seeking, accessing to and using family planning services

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

The human O-acetyl-ADP-ribose deacetylase MDO1 is a mono-ADP-ribosylhydrolase involved in the reversal of post-translational modifications. Until now MDO1 has been poorly characterized, partly since no ligand is known besides adenosine nucleotides. Here, we synthesized thirteen compounds retaining the adenosine moiety and bearing bioisosteric replacements of the phosphate at the ribose 50-oxygen. These compounds are composed of either a squaryldiamide or an amide group as the bioisosteric replacement and/or as a linker. To these groups a variety of substituents were attached such as phenyl, benzyl, pyridyl, carboxyl, hydroxy and tetrazolyl. Biochemical evaluation showed that two compounds, one from both series, inhibited ADP-ribosyl hydrolysis mediated by MDO1 in high concentrations. (C) 2018 Elsevier Ltd. All rights reserved.Peer reviewe

Prevalence of Hepatitis B surface antigen (HBsAg) among visitors of Shashemene General Hospital voluntary counseling and testing center

<p>Abstract</p> <p>Background</p> <p>Hepatitis B virus (HBV) infection is significant health problem, as it can lead to chronic hepatitis, liver cirrhosis, and hepatic carcinoma. Due to shared routes of transmission, HBV and human immunodeficiency virus (HIV) co-infection is common and is an emerging concern in the clinical management of patients because of increased mortality, accelerated hepatic disease progression, and the frequent hepatotoxicity caused by anti-retroviral therapy. The aim of this study was to determine the prevalence of Hepatitis B surface antigen (HBsAg) and its risk factors, among individuals visiting Shashemene General Hospital VCT center.</p> <p>Findings</p> <p>Institution based cross-sectional study was performed from November 3, 2008 to December 29, 2008 and 384 voluntary counseling and testing (VCT) clients were investigated. Data on socio demographic and HBV risk factors was collected using structured questionnaires. Blood samples were collected and screened for hepatitis B surface antigen (HBsAg) and HIV by commercially available rapid test kits. The prevalence of HBsAg in this study group was 5.7%. Fourteen percent of HIV positive subjects (8/57) and 4.3% (14/327) of HIV negative subjects were positive for HBsAg. Significantly high prevalence of HBsAg was observed among individuals who had history of invasive procedures, like tooth extraction, abortion and ear piercing; history of hospital admission, history of unsafe inject and HIV positives.</p> <p>Conclusions</p> <p>Although HBsAg prevalence is much higher among subjects who are HIV positive (14.0% versus 4.3%), the prevalence of HBsAg in HIV negative subjects is high enough to warrant a recommendation to screen all clients at VCT centers irrespective of HIV status.</p

Variability in practices for drinking water vaccination of meat chickens against infectious laryngotracheitis

Context: Drinking water vaccination of young meat chickens with Infectious Laryngotracheitis (ILT) vaccine is problematic. Vaccine failure and adverse vaccine reactions are frequently reported. Variations in the technique of applying ILT vaccines by this mass vaccination method need to be understood to contribute to improving the success of vaccination. Aims: This study aimed to examine variations in the techniques of application of Infectious Laryngotracheitis vaccines via drinking water for young meat chickens. Methods: Drinking water vaccination techniques were observed and recorded across 52 broiler flocks during ILT outbreaks in three geographic areas of Australia. Descriptive statistics for all variables were computed and variations between integrator company procedures were statistically compared. Key results: Despite rigorous standard operating procedures, wide variations were observed in time of water deprivation prior to vaccination (3–15 min), time drinking water was stabilised prior to addition of vaccine and the type of stabiliser product used, time to activate the flock following filling of the water lines with vaccine (10–127 min), time for the vaccine to be consumed (36–226 min) and the volume of drinking water per bird used to provide the vaccine (11–48 mL/bird). Conclusions: Variation in vaccination technique can affect the success of drinking water vaccination against ILT in young meat chickens. Implications: Understanding the importance of the variable factors in vaccine application method can improve the success of water vaccination against ILT

Variability in practices for drinking water vaccination of meat chickens against infectious laryngotracheitis

Context. Drinking water vaccination of young meat chickens with Infectious Laryngotracheitis (ILT) vaccine is problematic. Vaccine failure and adverse vaccine reactions are frequently reported. Variations in the technique of applying ILT vaccines by this mass vaccination method need to be understood to contribute to improving the success of vaccination.Aims. This study aimed to examine variations in the techniques of application of Infectious Laryngotracheitis vaccines via drinking water for young meat chickens.Methods. Drinking water vaccination techniques were observed and recorded across 52 broiler flocks during ILT outbreaks in three geographic areas of Australia. Descriptive statistics for all variables were computed and variations between integrator company procedures were statistically compared.Key results. Despite rigorous standard operating procedures, wide variations were observed in time of water deprivation prior to vaccination (3–15 min), time drinking water was stabilised prior to addition of vaccine and the type of stabiliser product used, time to activate the flock following filling of the water lines with vaccine (10–127 min), time for the vaccine to be consumed (36–226 min) and the volume of drinking water per bird used to provide the vaccine (11–48 mL/bird).Conclusions. Variation in vaccination technique can affect the success of drinking water vaccination against ILT in young meat chickens.Implications. Understanding the importance of the variable factors in vaccine application method can improve the success of water vaccination against ILT

The Prevalence, Determinants, and Health Risks of Domestic Violence in Gedeo and West Gujji Zones, Southern Ethiopia: An Evidence-based Study

This study was aimed at looking in to women’s experiences of violence in the home in selected woreda’s of Gedeo and West Gujji Zones. Mixed research approach was employed to collect the required data from victims of domestic violence, police officers, and officials and experts in concerned government offices. The quantitative data collected was analysed using the Statistical Package for Social Sciences (SPSS) version 21 and thematic analysis method was employed for qualitative data. The result revealed those women’s accounts of abuse is a complex phenomenon because it includes various forms, ranging from humiliation, threats and social isolation to forced sex and battering. Violence against women runs along a range, often escalating from milder forms to more serious acts. The finding indicated that men who are physically abusive are also psychologically, economically and sexually abusive. In this study, Economic dependence, and transgressions of gender role were found to be the main causes of domestic violence. Alcoholism, jealousy and masculinity linked to dominance were also mentioned as factors of violence. Domestic violence has profound consequences on women’s overall well-being. The experience of domestic violence puts women at greater risk of physical, social, mental and health problems. With regard to response to domestic violence, the study shows that some abused women are not passive victims but rather adopt active strategies to maximize their and their children safety. As economic dependence was found to be the prominent cause for domestic violence the researchers suggest the integrated interventions of stakeholders to economic empowerment of women to scale up the capabilities of women in household decision making thereby reducing the likelihood of violence in the home. Furthermore, enforcing the existing legal frameworks related to domestic violence and enacting additional responsive regulations on domestic violence is imperative to protect the victims of domestic violence

Assessing the Industrial Effluent Effect on Irrigation Water Quality and Farm Soil near Kombolcha Town, Ethiopia

This study evaluated various industrial effluents’ effect on irrigation water quality and farm soil near Kombolcha town. Several industries such as brewery, steel iron, textile, and tannery have been installed near the Borkena River that crosses Kombolcha town. Representative samples of irrigation water and farm soil were collected from the upper and down part of Borkena river. The upper site was used as a control as it was not contaminated by industrial effluents. The analysis for selected parameters showed that the downstream irrigation water quality had mean concentrations of pH = 8.54, magnesium (Mg+2) = 5.27 mg/l, carbonate (CO3−2) = 1.25 mg/l, bicarbonate (HCO3−) = 9.10 mg/l, copper (Cu) = 0.21 mg/l, chromium (Cr) = 0.31 mg/l, and cadmium (Cd) = 0.03 mg/l which were above the permissible limit of the Food and Agriculture Organization’s (FAO’s) irrigation water quality standard. The mean concentrations of electric conductivity (EC) = 0.96 ds/m, sodium (Na+) = 3.35 mg/l, chloride (Cl−) = 7.67 mg/l, and total dissolved solids (TDS) = 612.98 mg/l were slightly and moderately restricted for irrigation. Moreover, the concentration of heavy metals, calcium (Ca+2) = 16.61 mg/l, iron (Fe) = 4.25 mg/l, manganese (Mn) = 0.18 mg/l, and lead (Pb) = 0.47 mg/l, was below the permissible limit of the FAO and nonrestricted. However, the mean concentration of EC, HCO3−, Cu, Cr, Cd, and TDS for downstream-irrigated farm soil samples was above the permissible limit of the FAO. The concentration of most selected parameters in downstream farm soil was also decreasing along with depth except pH, CO3−2, and HCO3-. Generally, there is a significant quality difference (at P ≤ 0.05) between the upstream and downstream irrigation water quality on the parameters of Mg+2, Cl−, Pb, and Cu

Water Management: Insights from Two Distinct Sub-Saharan Africa

Water management seeks the optimal solutions to the challenges posed by society’s demand for food security, energy production, socioeconomic advancement, and sound ecosystems. In the 21st century, the complexities of natural disasters and human-induced factors impede the ability to address water security issues. Sub-Saharan Africa is at a critical juncture where it must implement substantial reforms in the planning and management of its water systems to enhance the sustainability of its water resources. Yet, the region faces numerous water-related issues due to complex natural disasters and human factors such as urbanization and population growth, particularly in countries like Ethiopia and Mauritania. This paper delves into the availability, sustainability, management, and governance of water in these two regions of Horn Africa (Ethiopia) and Western Africa (Mauritania). It also highlights the practices involved in planning, managing, and utilizing water systems and services in these areas. Therefore, this paper provides a foundation for further research and the development of sustainable water resources management in the region

Protection Efficacy of the Infectious Laryngotracheitis (ILT) Serva CEO Vaccine Strain in Broiler Chickens Under Different Vaccination Coverage Conditions

Mass vaccination against infectious laryngotracheitis virus (ILTV) in drinking water can result in variable initial vaccine take. Partial initial vaccine coverage of 20% with an Australian ILT vaccine (A20) previously resulted in significant protection against virulent ILTV challenge. This follow-up study used the international Serva ILT vaccine strain in a factorial design testing four levels of vaccination coverage (0%, 10%, 20%, or 100% of chicks eye-drop vaccinated with the live vaccine at 7 days of age) and three levels of ILTV challenge (no challenge or challenge at 7 or 21 days postvaccination [DPV]). The increase in ILTV load in choanal cleft swabs detected by qPCR after challenge was significantly reduced by 20% and 100% but not by 10% vaccination coverage. Vaccination reduced weight gain in unchallenged birds. Daily weight gain of birds was not affected by ILTV challenge at 7 DPV in any group, but following challenge at 21 DPV, it was significantly reduced in unvaccinated and 10% vaccinated groups relative to 20% and 100% vaccinated groups. Vaccination of 20% of the chickens provided substantial but incomplete protection (protective index range 44%–70%) against the severity of clinical signs and mortality following challenge while 10% vaccination coverage provided limited or no protection. Clinical signs were more severe and appeared earlier following challenge at 21 DPV than at 7 DPV. Within the vaccination treatments, eye-drop-vaccinated birds were better protected than their in-contact cohorts. In conclusion, partial vaccination of 20%, but not 10% of chickens, induced substantial protection against subsequent challenge. However, the attendant risks of reduced protection against early challenge and the possible reversion to virulence of vaccine virus when transmitted to unvaccinated chickens make it essential that 100% initial vaccine take be the goal of mass vaccination programs