3,410 research outputs found
GSK3β regulates oligodendrogenesis in the dorsal microdomain of the subventricular zone via Wnt-β-catenin signaling
A study of the Haor areas of Sylhet-Mymensing districts with ERTS imageries (winter crop estimation)
There are no author-identified significant results in this report
A new species of the genus Gomphomastax Brunner von Wattenwyl (Orthoptera: Eumastacidae: Gomphomastacinae) from Indian Kashmir
A new species, Gomphomastax nigrovittata Usmani, from Kashmir is described and illustrated. In addition to conventional morphological characters, genitalic structures are also studied. A key to known species of Gomphomastax from Indian Kashmir is given
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Primordial germ cell specification: a context-dependent cellular differentiation event [corrected].
During embryonic development, the foundation of the germline is laid by the specification of primordial germ cells (PGCs) from the postimplantation epiblast via bone morphogenetic protein (BMP) and WNT signalling. While the majority of epiblast cells undergo differentiation towards somatic cell lineages, PGCs initiate a unique cellular programme driven by the cooperation of the transcription factors BLIMP1, PRDM14 and AP2γ. These factors synergistically suppress the ongoing somatic differentiation and drive the re-expression of pluripotency and germ cell-specific genes accompanied by global epigenetic changes. However, an unresolved question is how postimplantation epiblast cells acquire the developmental competence for the PGC fate downstream of BMP/WNT signalling. One emerging concept is that transcriptional enhancers might play a central role in the establishment of developmental competence and the execution of cell fate determination. Here, we discuss recent advances on the specification and reprogramming of PGCs thereby highlighting the concept of enhancer function.U.G. is supported by a Marie Curie Intra-European
fellowship. E.M. is supported by the Icelandic Research Fund.
M.A.S. is supported by the Wellcome Trust (WT096738).This is the final version. It was first published by Royal Society Publishing at http://rstb.royalsocietypublishing.org/content/369/1657/2013054
Self Consistent Simulation of C-V Characterization and Ballistic Performance of Double Gate SOI Flexible-FET Incorporating QM Effects
Capacitance-Voltage (C-V) & Ballistic Current- Voltage (I-V) characteristics
of Double Gate (DG) Silicon-on- Insulator (SOI) Flexible FETs having sub 35nm
dimensions are obtained by self-consistent method using coupled Schrodinger-
Poisson solver taking into account the quantum mechanical effects. Although,
ATLAS simulations to determine current and other short channel effects in this
device have been demonstrated in recent literature, C-V & Ballistic I-V
characterizations by using self-consistent method are yet to be reported. C-V
characteristic of this device is investigated here with the variation of bottom
gate voltage. The depletion to accumulation transition point (i.e. Threshold
voltage) of the C-V curve should shift in the positive direction when the
bottom gate is negatively biased and our simulation results validate this
phenomenon. Ballistic performance of this device has also been studied with the
variation of top gate voltage.Comment: 4 pages, ICEDSA 2012 conferenc
A Physically Based Analytical Modeling of Threshold Voltage Control for Fully-Depleted SOI Double Gate NMOS-PMOS Flexible-FET
In this work, we propose an explicit analytical equation to show the
variation of top gate threshold voltage with respect to the JFET bottom gate
voltage for a Flexible Threshold Voltage Field Effect Transistor (Flexible-FET)
by solving 2-D Poisson's equation with appropriate boundary conditions,
incorporating Young's parabolic approximation. The proposed model illustrates
excellent match with the experimental results for both n-channel and p-channel
180nm Flexible-FETs. Threshold voltage variation with several important device
parameters (oxide and silicon channel thickness, doping concentration) is
observed which yields qualitative matching with results obtained from SILVACO
simulations.Comment: 4 pages, EIT 2012-IUPUI conferenc
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ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage.
BACKGROUND: Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells. Transcriptional regulators, such as Oct4, are critical for pluripotency, but the role of epigenetic modifiers remains to be fully elucidated. RESULTS: Here, we show that ERG-associated protein with SET domain (ESET), a histone methyltransferase enzyme, maintains pluripotency through repression of Cdx2, a key trophectoderm determinant, by histone H3 lysine 9 trimethylation (H3K9me3) of the promoter region. Notably, this repression is mediated through the synergistic function of small ubiquitin-related modifier (SUMO)ylated ESET and Oct4. ESET localises to the promyelocytic leukaemia (PML) nuclear bodies and is SUMOylated in ES cells. Interaction of ESET with Oct4 depends on a SUMO-interacting motif (SIM) in Oct4, which is critical for the repression of Cdx2. CONCLUSION: Loss of ESET or Oct4 results in strikingly similar phenotypes both in ES cells with their differentiation into trophectoderm cells, and in early embryos where there is a failure of development of the pluripotent inner cell mass (ICM) of blastocysts. We propose that SUMOylated ESET-Oct4 complex is critical for both the initiation and maintenance of pluripotency through repression of differentiation, particularly of the trophectoderm lineage by epigenetic silencing of Cdx2.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
Mobile Computing in Physics Analysis - An Indicator for eScience
This paper presents the design and implementation of a Grid-enabled physics
analysis environment for handheld and other resource-limited computing devices
as one example of the use of mobile devices in eScience. Handheld devices offer
great potential because they provide ubiquitous access to data and
round-the-clock connectivity over wireless links. Our solution aims to provide
users of handheld devices the capability to launch heavy computational tasks on
computational and data Grids, monitor the jobs status during execution, and
retrieve results after job completion. Users carry their jobs on their handheld
devices in the form of executables (and associated libraries). Users can
transparently view the status of their jobs and get back their outputs without
having to know where they are being executed. In this way, our system is able
to act as a high-throughput computing environment where devices ranging from
powerful desktop machines to small handhelds can employ the power of the Grid.
The results shown in this paper are readily applicable to the wider eScience
community.Comment: 8 pages, 7 figures. Presented at the 3rd Int Conf on Mobile Computing
& Ubiquitous Networking (ICMU06. London October 200
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