Field theoretic calculation of scalar turbulence

The cascade rate of passive scalar and Bachelor's constant in scalar turbulence are calculated using the flux formula. This calculation is done to first order in perturbation series. Batchelor's constant in three dimension is found to be approximately 1.25. In higher dimension, the constant increases as $d^{1/3}$.Comment: RevTex4, publ. in Int. J. Mod. Phy. B, v.15, p.3419, 200

Energy fluxes in helical magnetohydrodynamics and dynamo action

Renormalized viscosity, renormalized resistivity, and various energy fluxes are calculated for helical magnetohydrodynamics using perturbative field theory. The calculation is to first-order in perturbation. Kinetic and magnetic helicities do not affect the renormalized parameters, but they induce an inverse cascade of magnetic energy. The sources for the the large-scale magnetic field have been shown to be (1) energy flux from large-scale velocity field to large-scale magnetic field arising due to nonhelical interactions, and (2) inverse energy flux of magnetic energy caused by helical interactions. Based on our flux results, a premitive model for galactic dynamo has been constructed. Our calculations yields dynamo time-scale for a typical galaxy to be of the order of $10^8$ years. Our field-theoretic calculations also reveal that the flux of magnetic helicity is backward, consistent with the earlier observations based on absolute equilibrium theory.Comment: REVTEX4; A factor of 2 corrected in helicit

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the development of small molecule inhibitors. Thus, to exploit fully the potential of the Human Genome Project to advance human medicine, there is a need to develop generic methods of inhibiting protein activity that do not rely on the target protein’s function. We previously demonstrated that a normally stable protein, methionine aminopeptidase-2 or MetAP-2, could be artificially targeted to an Skp1-Cullin-F-box (SCF) ubiquitin ligase complex for ubiquitination and degradation through a chimeric bridging molecule or Protac (proteolysis targeting chimeric molecule). This Protac consisted of an SCFß-TRCP-binding phosphopeptide derived from I{kappa}B{alpha} linked to ovalicin, which covalently binds MetAP-2. In this study, we employed this approach to target two different proteins, the estrogen (ER) and androgen (AR) receptors, which have been implicated in the progression of breast and prostate cancer, respectively. We show here that an estradiol-based Protac can enforce the ubiquitination and degradation of the {alpha} isoform of ER in vitro, and a dihydroxytestosterone-based Protac introduced into cells promotes the rapid disappearance of AR in a proteasome-dependent manner. Future improvements to this technology may yield a general approach to treat a number of human diseases, including cancer

Efficient absolute aspect determination of a balloon borne far infrared telescope using a solid state optical photometer

The observational and operational efficiency of the TIFR 1 meter balloon borne far infrared telescope has been improved by incorporating a multielement solid state optical photometer (SSOP) at the Cassegrain focus of the telescope. The SSOP is based on a 1-D linear photo diode array (PDA). The online and offline processing schemes of the PDA signals which have been developed, lead to improvement in the determination of absolute telescope aspect ($\sim$ 0\farcm8), which is very crucial for carrying out the observations as well as offline analysis. The SSOP and its performance during a recent balloon flight are presented here.Comment: To appear in the February 2000 issue of the PAS

Unconditional violation of the shot noise limit in photonic quantum metrology

Interferometric phase measurement is widely used to precisely determine quantities such as length, speed, and material properties. Without quantum correlations, the best phase sensitivity $\Delta\varphi$ achievable using $n$ photons is the shot noise limit (SNL), $\Delta\varphi=1/\sqrt{n}$. Quantum-enhanced metrology promises better sensitivity, but despite theoretical proposals stretching back decades, no measurement using photonic (i.e. definite photon number) quantum states has truly surpassed the SNL. Rather, all such demonstrations --- by discounting photon loss, detector inefficiency, or other imperfections --- have considered only a subset of the photons used. Here, we use an ultra-high efficiency photon source and detectors to perform unconditional entanglement-enhanced photonic interferometry. Sampling a birefringent phase shift, we demonstrate precision beyond the SNL without artificially correcting our results for loss and imperfections. Our results enable quantum-enhanced phase measurements at low photon flux and open the door to the next generation of optical quantum metrology advances.Comment: 5 pages,3 figure

Non-local interactions in hydrodynamic turbulence at high Reynolds numbers: the slow emergence of scaling laws

We analyze the data stemming from a forced incompressible hydrodynamic simulation on a grid of 2048^3 regularly spaced points, with a Taylor Reynolds number of Re~1300. The forcing is given by the Taylor-Green flow, which shares similarities with the flow in several laboratory experiments, and the computation is run for ten turnover times in the turbulent steady state. At this Reynolds number the anisotropic large scale flow pattern, the inertial range, the bottleneck, and the dissipative range are clearly visible, thus providing a good test case for the study of turbulence as it appears in nature. Triadic interactions, the locality of energy fluxes, and structure functions of the velocity increments are computed. A comparison with runs at lower Reynolds numbers is performed, and shows the emergence of scaling laws for the relative amplitude of local and non-local interactions in spectral space. The scalings of the Kolmogorov constant, and of skewness and flatness of velocity increments, performed as well and are consistent with previous experimental results. Furthermore, the accumulation of energy in the small-scales associated with the bottleneck seems to occur on a span of wavenumbers that is independent of the Reynolds number, possibly ruling out an inertial range explanation for it. Finally, intermittency exponents seem to depart from standard models at high Re, leaving the interpretation of intermittency an open problem.Comment: 8 pages, 8 figure

Study of Distribution and Asymmetry of Solar Active Prominences During Solar Cycle 23

In this paper we present the results of a study of the spatial distribution and asymmetry of solar active prominences (SAP) for the period 1996-2007 (solar cycle 23). For more meaningful statistical analysis we have analysed the distribution and asymmetry of SAP in two subdivisions viz. Group1 (ADF, APR, DSF, CRN, CAP) and Group2 (AFS, ASR, BSD, BSL, DSD, SPY, LPS). The north-south (N-S) latitudinal distribution shows that the SAP events are most prolific in the 21-30degree slice in the northern and southern hemispheres and east-west (E-W) longitudinal distribution study shows that the SAP events are most prolific (best visible) in the 81-90degree slice in the eastern and western hemispheres. It has been found that the SAP activity during this cycle is low compared to previous solar cycles. The present study indicates that during the rising phase of the cycle the number of SAP events were roughly equal on the north and south hemispheres. However, activity on the southern hemisphere has been dominant since 1999. Our statistical study shows that the N-S asymmetry is more significant then the E-W asymmetry.Comment: 21 pages 5 figures; Published online; 02 October, 2009; Solar Physics Journa

Characteristics of Fatal Cases of Pandemic Influenza A (H1N1) from September 2009 to January 2010 in Saurashtra Region, India

Background: India reported first case of 2009 pandemic influenza A (H1N1) virus infection in May, 2009 and Saurashtra region in August, 2009. We describe the characteristics of fatal cases of 2009 influenza A (H1N1) infection reported in Saurashtra region. Methods: From September, 2009 to January, 2010, we observed 71 fatal cases that were infected with 2009 influenza A (H1N1) virus and admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features were observed and documented. Results: Median age of the deceased (71) was 29 years, and 57.7% were females. Median time observed was 5 days from onset of illness to diagnosis of influenza A (H1N1), and 57.7% were referred from general practitioner (OR=0.42, CI=0.24-0.74). Median hospital stay reported was 3 days. All admitted patients received oseltamivir, but only 16.9% received it within 2 days of onset of illness. The most common symptoms were cough (97.2%), fever (93%), sore throat and shortness of breath. Co-morbid conditions were present in almost half of the patients who ultimately died, the most common of which was pregnancy (OR=0.15, CI=0.04-0.52). Radiological pneumonia was reported in 98% patients. Conclusion: Residing in urban area, delayed referral from general practitioner, presence of co-existing condition, especially pregnancy was responsible for mortality among influenza A (H1N1) infected positive