An Observational Cohort Study on Delayed-Onset Infections after Mandibular Third-Molar Extractions.

OBJECTIVES: The purpose of the present study was to investigate the occurrence and clinical features of delayed-onset infections after mandibular third-molar extractions. METHOD AND MATERIALS: An observational cohort study was conducted on 179 patients undergoing mandibular third-molar extraction between January 2013 and December 2015, for a total of 217 extractions. Data were recorded at the time of extraction (T0), on suture removal seven days later (T1), and 30 days after the extraction, when patients were contacted and asked about their healing process (T2). The statistical analysis was performed with nonparametric tests. A p value lower than 0.05 was considered statistically significant. RESULTS: Eight delayed-onset infections were recorded, amounting to 3.7% of all extractions. The median time elapsing from the extraction to the delayed-onset infection was 35 days (IQR 28-40; min 24-max 49). Younger age and longer surgical procedures seemed to be more often associated with this complication. CONCLUSION: Delayed-onset infections after third-molar extractions are relatively rare postoperative complications characterized by a swelling, usually with a purulent discharge. Patients should be informed of this possibility, which might develop even several weeks after the extraction

Influence of seismic activity on the atmospheric electric field in Lisbon (Portugal) from 1955 to 1991

In the present study, we considered the influence of seismic activity on the atmospheric electric field recorded at Portela meteorological station (Lisbon, Portugal) for the period from 1955 to 1991. To this end, an exploratory method was developed, which involved the selection of events for which the distance from the atmospheric electrical field sensor to the earthquake epicenter is smaller than the preparation radius of the event. This enabled the correlation of the atmospheric electric field variations with a quantity S, defined basically as the ratio of the earthquake preparation radius to the distance between the sensor and the event epicenter. The first results show promising perspectives, but clearly a more profound study is required, in which a careful analysis of the weather conditions and other variables, like atmospheric radon levels, must be considered

A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells.

Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent patents regarding oily formulations containing probiotics (WO2010122107A1 and WO2010103374A9) and the use of probiotics for gastrointestinal complaints (US20110110905A1 and US9057112B2) exist, or are pending application. Objective: In this work, we studied the effect of a fixed combination of registered Lactobacillus reuteri and Lactobacillus acidophilus strains and herbal extracts in an in vitro inflammation experimental model. Methods: Caco-2 cell monolayer was exposed to INF-\u3b3+TNF-\u3b1 or to LPS; Trans Epithelial Electrical Resistance (TEER) and paracellular permeability were investigated. ZO-1 and occludin Tight Junctions (TJs) were also investigated by mean of immunofluorescence. Results: Pre-treatment with the fixed combination of probiotics and herbal extracts prevented the inflammation-induced TEER decrease, paracellular permeability increase and TJs translocation. Conclusions: In summary, the fixed combination of probiotics and herbal extracts investigated in this research was found to be an interesting candidate for targeting the re-establishment of intestinal barrier function in IBD conditions

SEISMO-ELECTROMAGNETIC PHENOMENA IN TECTONICALLY ACTIVE REGIONS

This work presents a research plan that aims to monitor seismo-electromagnetic signals in seismic active regions. Two effects will be considered: electromagnetic field emissions and radio broadcastings. Our study will be focused in the analysis of low magnitude earthquakes almost completely disregarded in literature. We aim to collect novel seismo-electromagnetic emission data emerging from seismic activity. We expect to address the time variation of electromagnetic properties of the crust in relation with the strain field and complement it with the development of proper models. Experimental studies based on the electrical properties of rocks will also be done aiming the understanding of pressure stimulated currents and voltages that produce detectable electromagnetic radiation and can be a cause for seismo-electromagnetic signals

Seismo-electromagnetic phenomena in the western part of the Eurasia-Nubia plate boundary

This paper presents a future research plan that aims to monitor Seismo-electromagnetic (SEM) phenomena in the western part of the Eurasia-Nubia plate boundary (WENP). This region has a significant tectonic activity [1] combined with relatively low electromagnetic noise levels and for that reason presents the possibility to perform high quality SEM measurements. Further, it is known that low-frequency [ultra (ULF), very (VLF), and low-frequencies (LF)] electromag- netic (EM) waves produce more convincing earthquake precursors (compared to higher frequencies) because of less contamination, large skin depth, and low attenuation [2]. Thus, two SEM effects will be considered: ULF electromagnetic field emissions [3], and VLF/LF radio broadcastings [4]. With respect to the ULF measurements, as a start, three ULF sensors are planned to be installed in the South of Iberian Peninsula supported by the existing networks of seismic research stations. Subsequent devel- opment of this initial plan could result in the implementation of a lager ULF monitoring network not only in the Iberian Peninsula, but also in the rest of Europe. Possible integration in the SEGMA array is now under consideration. Another perspective is to use a portable station to track seismic events. Regarding the VLF/LF radio broadcastings, a receiver is planned to be mounted in University of Évora. Radio signals from up to 10 transmitters (in these bands) of interest to study the seismic activity in the WENP region will be monitored. Actually, the radio path from the transmitter to the receiver should cross the epicentral area, therefore two possible transmitters are the ones installed in Monaco (France) and Sicily (Italy). Furthermore, the system will integrate the INFREP network and in this context it will not be restricted to WENP region. With the development of these research plans we aim to collect novel SEM data emerging from the seis- mic activity in the WENP region. We expect to address the time variations of EM properties of the crust/plate in relation with the strain field, and in space in relation with composition and temperature and stress fields. Further, the interplay between atmospheric (and solar) perturbations with crust perturbations will be monitored, to observe geomagnetic perturbations at different locations. Our study will be focused in the analyses of low magnitude earthquakes with M =< 4, these events are frequent in the WENP region, but have been almost completely disregarded in literature [5,6]. [1] J. Borges, A. J. S. Fitas, M. Bezzeghoud, and P. Teves-Costa, Tectonophysics 337, 373 (2001). [2] V. Chauhan, O.P. Singh, V. Kushwah, V. Singh, B. Singh, Journal of Geodynamics 48, 68 (2009). [3] L. Telesca, V. Lapenna, M. Macchiato, and K. Hattori, Earth and Planet. Science Lett. 268, 219 (2008)

Seismo-electromagnetic phenomena in the western part of the Eurasia-Nubia plate boundary

This paper presents a future research plan that aims to monitor Seismo-electromagnetic (SEM) phenomena in the western part of the Eurasia-Nubia plate boundary (WENP). This region has a significant tectonic activity [1] combined with relatively low electromagnetic noise levels and for that reason presents the possibility to perform high quality SEM measurements. Further, it is known that low-frequency [ultra (ULF), very (VLF), and low-frequencies (LF)] electromag- netic (EM) waves produce more convincing earthquake precursors (compared to higher frequencies) because of less contamination, large skin depth, and low attenuation [2]. Thus, two SEM effects will be considered: ULF electromagnetic field emissions [3], and VLF/LF radio broadcastings [4]. With respect to the ULF measurements, as a start, three ULF sensors are planned to be installed in the South of Iberian Peninsula supported by the existing networks of seismic research stations. Subsequent devel- opment of this initial plan could result in the implementation of a lager ULF monitoring network not only in the Iberian Peninsula, but also in the rest of Europe. Possible integration in the SEGMA array is now under consideration. Another perspective is to use a portable station to track seismic events. Regarding the VLF/LF radio broadcastings, a receiver is planned to be mounted in University of Évora. Radio signals from up to 10 transmitters (in these bands) of interest to study the seismic activity in the WENP region will be monitored. Actually, the radio path from the transmitter to the receiver should cross the epicentral area, therefore two possible transmitters are the ones installed in Monaco (France) and Sicily (Italy). Furthermore, the system will integrate the INFREP network and in this context it will not be restricted to WENP region. With the development of these research plans we aim to collect novel SEM data emerging from the seis- mic activity in the WENP region. We expect to address the time variations of EM properties of the crust/plate in relation with the strain field, and in space in relation with composition and temperature and stress fields. Further, the interplay between atmospheric (and solar) perturbations with crust perturbations will be monitored, to observe geomagnetic perturbations at different locations. Our study will be focused in the analyses of low magnitude earthquakes with M =< 4, these events are frequent in the WENP region, but have been almost completely disregarded in literature [5,6]. [1] J. Borges, A. J. S. Fitas, M. Bezzeghoud, and P. Teves-Costa, Tectonophysics 337, 373 (2001). [2] V. Chauhan, O.P. Singh, V. Kushwah, V. Singh, B. Singh, Journal of Geodynamics 48, 68 (2009). [3] L. Telesca, V. Lapenna, M. Macchiato, and K. Hattori, Earth and Planet. Science Lett. 268, 219 (2008)

Charge Transfer and Charge Broadening of GEM Structures in High Magnetic Fields

We report on measurements of charge transfer in GEM structures in high magnetic fields. These were performed in the framework of the R&D work for a Time Projection Chamber at a future Linear Collider. A small test chamber has been installed into the aperture of a superconducting magnet with the GEM structures mounted perpendicular to the B field direction. The charge transfer is derived from the electrical currents monitored during irradiation with an ${}^{55}$Fe source. No severe loss of primary ionisation charge is observed, but an improved ion feedback suppression is achieved for high magnetic fields. Additionally, the width of the charge cloud released by individual ${}^{55}$Fe photons is measured using a finely segmented strip readout after the triple GEM structure. Charge widths between 0.3 and 0.5 mm RMS are observed, which originate from the charge broadening inside the GEM readout. This charge broadening is only partly suppressed at high magnetic fields.Comment: 11 pages, 9 figure

lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis

Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any antitumor host immune response. Since Epstein-Barr virus (EBV)-associated tumors such as Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC) express FasL, we determined whether EBV-specific cytotoxic T lymphocytes (EBV-CTLs) could be modified to resist this evasion strategy. We show that long-term down-modulation of Fas can be achieved in EBV-CTLs by transduction with small interfering RNA (siRNA) encoded in a retrovirus. Modified T cells resisted Fas/FasL-mediated apoptosis compared with control cells and showed minimal cleavage of the caspase3 substrate poly(ADP-ribose) polymerase (PARP) protein after Fas engagement. Prolonged Fas stimulation selected a uniformly Fas(low) and FasL resistant population. Removal of responsiveness to this single death signal had no other discernible effects on EBV-CTLs. In particular, it did not lead to their autonomous growth since the modified EBV-CTLs remained polyclonal, and their survival and proliferation retained dependence on antigen-specific stimulation and on the presence of other physiologic growth signals. EBV-CTLs with knocked down Fas should have a selective functional and survival advantage over unmodified EBV-CTLs in the presence of tumors expressing FasL and may be of value for adoptive cellular therapy. (c) 2005 by The American Society of Hematology

Simulation of VUV electroluminescence in micropattern gaseous detectors: the case of GEM and MHSP

Electroluminescence produced during avalanche development in gaseous avalanche detectors is an useful information for triggering, calorimetry and tracking in gaseous detectors. Noble gases present high electroluminescence yields, emitting mainly in the VUV region. The photons can provide signal readout if appropriate photosensors are used. Micropattern gaseous detectors are good candidates for signal amplification in high background and/or low rate experiments due to their high electroluminescence yields and radiopurity. In this work, the VUV light responses of the Gas Electron Multiplier and of the Micro-Hole Strip Plate, working with pure xenon, are simulated and studied in detail using a new and versatile C++ toolkit. It is shown that the solid angle subtended by a photosensor placed below the microstructures depends on the operating conditions. The obtained absolute EL yields, determined for different gas pressures and as functions of the applied voltage, are compared with those determined experimentally.Comment: Accepted for publication in Journal of Instrumentatio