Dynamo action in thick disks around Kerr black holes: high-order resistive GRMHD simulations

We present the first kinematic study of an $\alpha\Omega$-dynamo in the General Relativistic Magneto-HydroDynamics (GRMHD) regime, applied to thick disks orbiting around Kerr black holes and using a fully covariant mean field dynamo closure for the Ohm law. We show that the $\alpha\Omega$-dynamo mechanism leads to a continuous exponential growth of the magnetic field within the disk and to the formation of dynamo waves drifting away or toward the equatorial plane. Since the evolution of the magnetic field occurs qualitatively in the same fashion as in the Sun, we present also butterfly diagrams that characterize our models and show the establishment of an additional timescale, which depends on the microscopic properties of the turbulent motions, possibly providing an alternative explanation to periodicities observed in many high-energy astrophysical sources where accretion onto a rotating black hole is believed to operate.Comment: 5 pages, 4 figures. Accepted for publication in MNRA

Fast reconnection in relativistic plasmas: the magnetohydrodynamics tearing instability revisited

Fast reconnection operating in magnetically dominated plasmas is often invoked in models for magnetar giant flares, for magnetic dissipation in pulsar winds, or to explain the gamma-ray flares observed in the Crab nebula, hence its investigation is of paramount importance in high-energy astrophysics. Here we study, by means of two dimensional numerical simulations, the linear phase and the subsequent nonlinear evolution of the tearing instability within the framework of relativistic resistive magnetohydrodynamics, as appropriate in situations where the Alfven velocity approaches the speed of light. It is found that the linear phase of the instability closely matches the analysis in classical MHD, where the growth rate scales with the Lundquist number S as S^-1/2, with the only exception of an enhanced inertial term due to the thermal and magnetic energy contributions. In addition, when thin current sheets of inverse aspect ratio scaling as S^-1/3 are considered, the so-called "ideal" tearing regime is retrieved, with modes growing independently on S and extremely fast, on only a few light crossing times of the sheet length. The overall growth of fluctuations is seen to solely depend on the value of the background Alfven velocity. In the fully nonlinear stage we observe an inverse cascade towards the fundamental mode, with Petschek-type supersonic jets propagating at the external Alfven speed from the X-point, and a fast reconnection rate at the predicted value R~(ln S)^-1.Comment: 14 pages, 9 figures, accepted for publication (MNRAS

Functionalized PLGA-Based Nanoparticles with Anti-HSV-2 Human Monoclonal Antibody: A Proof of Concept for Early Diagnosis and Targeted Therapy

Background: Functionalized nanoparticles (NPs) represent a cutting edge in innovative clinical approaches, allowing for the delivery of selected compounds with higher specificity in a wider time frame. They also hold promise for novel theranostic applications that integrate both diagnostic and therapeutic functions. Pathogens are continuously evolving to try to escape the strategies designed to treat them. Objectives: In this work, we describe the development of a biotechnological device, Nano-Immuno-Probes (NIPs), for early detection and infections treatment. Human Herpes Simplex Virus 2 was chosen as model pathogen. Methods: NIPs consist of PLGA-PEG-Sulfone polymeric NPs conjugated to recombinant Fab antibody fragments targeting the viral glycoprotein G2. NIPs synthesis involved multiple steps and was validated through several techniques. Results: DLS analysis indicated an expected size increase with a good polydispersity index. Z-average and z-potential values were measured for PLGA-PEG-Bis-Sulfone NPs (86.6 +/- 10.9 nm; -0.7 +/- 0.3 mV) and NIPs (151 +/- 10.4 nm; -5.1 +/- 1.9 mV). SPR assays confirmed NIPs' specificity for the glycoprotein G2, with an apparent KD of 1.03 +/- 0.61 mu M. NIPs exhibited no cytotoxic effects on VERO cells at 24 and 48 h. Conclusions: This in vitro study showed that NIPs effectively target HSV-2, suggesting the potential use of these nanodevices to deliver both contrast agents as well as therapeutic compounds