Resonance-continuum interference in the di-photon Higgs signal at the LHC

A low mass Standard Model Higgs boson should be visible at the Large Hadron Collider through its production via gluon-gluon fusion and its decay to two photons. We compute the interference of this resonant process, gg -> H -> gamma gamma, with the continuum QCD background, gg -> gamma gamma induced by quark loops. Helicity selection rules suppress the effect, which is dominantly due to the imaginary part of the two-loop gg -> gamma gamma scattering amplitude. The interference is destructive, but only of order 5% in the Standard Model, which is still below the 10-20% present accuracy of the total cross section prediction. We comment on the potential size of such effects in other Higgs models.Comment: 10 pages, 2 figure

Non-equilibrium phase transition in a sheared granular mixture

The dynamics of an impurity (or tracer particle) immersed in a dilute granular gas under uniform shear flow is investigated. A non-equilibrium phase transition is identified from an exact solution of the inelastic Boltzmann equation for a granular binary mixture in the tracer limit, where the impurity carries either a vanishing (disordered phase) or a finite (ordered phase) fraction of the total kinetic energy of the system. In the disordered phase, the granular temperature ratio (impurity "temperature" over that of the host fluid) is finite, while it diverges in the ordered phase. To correctly capture this extreme violation of energy equipartition, we show that the picture of an impurity enslaved to the host fluid is insufficient

Broken symmetries and directed collective energy transport

We study the appearance of directed energy current in homogeneous spatially extended systems coupled to a heat bath in the presence of an external ac field E(t). The systems are described by nonlinear field equations. By making use of a symmetry analysis we predict the right choice of E(t) and obtain directed energy transport for systems with a nonzero topological charge Q. We demonstrate that the symmetry properties of motion of topological solitons (kinks and antikinks) are equivalent to the ones for the energy current. Numerical simulations confirm the predictions of the symmetry analysis and, moreover, show that the directed energy current drastically increases as the dissipation parameter $\alpha$ reduces. Our results generalize recent rigorous theories of currents generated by broken time-space symmetries to the case of interacting many-particle systems.Comment: 4 pages, 2 figure

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis

Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (IrIII) complexes [Ir(Cpx)(XY)Cl]+/0 (Cpx = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cpx ring. In comparison, highly potent complex 4 (Cpx = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these IrIII complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 μM) of the γ-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic IrIII complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands

Anatomy of the AGN in NGC 5548. III. The high-energy view with NuSTAR and INTEGRAL

We describe the analysis of the seven broad-band X-ray continuum observations of the archetypal Seyfert 1 galaxy NGC 5548 that were obtained with XMM-Newton or Chandra, simultaneously with high-energy (>10 keV) observations with NuSTAR and INTEGRAL. These data were obtained as part of a multiwavelength campaign undertaken from the summer of 2013 till early 2014. We find evidence of a high-energy cut-off in at least one observation, which we attribute to thermal Comptonization, and a constant reflected component that is likely due to neutral material at least a few light months away from the continuum source. We confirm the presence of strong, partial covering X-ray absorption as the explanation for the sharp decrease in flux through the soft X-ray band. The obscurers appear to be variable in column density and covering fraction on time scales as short as weeks. A fit of the average spectrum over the range 0.3–400 keV with a realistic Comptonization model indicates the presence of a hot corona with a temperature of 40^(+40)_(-10) keV and an optical depth of 2.7^(+0.7)_(-1.2) if a spherical geometry is assumed

Driven diffusion in a periodically compartmentalized tube: homogeneity versus intermittency of particle motion

We study the effect of a driving force F on drift and diffusion of a point Brownian particle in a tube formed by identical ylindrical compartments, which create periodic entropy barriers for the particle motion along the tube axis. The particle transport exhibits striking features: the effective mobility monotonically decreases with increasing F, and the effective diffusivity diverges as F → ∞, which indicates that the entropic effects in diffusive transport are enhanced by the driving force. Our consideration is based on two different scenarios of the particle motion at small and large F, homogeneous and intermittent, respectively. The scenarios are deduced from the careful analysis of statistics of the particle transition times between neighboring openings. From this qualitative picture, the limiting small-F and large-F behaviors of the effective mobility and diffusivity are derived analytically. Brownian dynamics simulations are used to find these quantities at intermediate values of the driving force for various compartment lengths and opening radii. This work shows that the driving force may lead to qualitatively different anomalous transport features, depending on the geometry design

Angiographic Findings of the Multicenter Randomized Study With the Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent (RAVEL)

BACKGROUND: Restenosis remains the major limitation of coronary catheter-based intervention. In small vessels, the amount of neointimal tissue is disproportionately greater than the vessel caliber, resulting in higher restenosis rates. In the Randomized Study With the Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent (RAVEL) trial, approximately 40% of the vessels were small (<2.5 mm). The present study evaluates the relationship between angiographic outcome and vessel diameter for sirolimus-eluting stents. METHODS AND RESULTS: Patients were randomized to receive either an 18-mm bare metal Bx VELOCITY (BS group, n=118), or a sirolimus-eluting Bx VELOCITY stent (SES group, n=120). Subgroups were stratified into tertiles according to their reference diameter (RD; stratum I, RD 2.84 mm). At 6-month follow-up, the restenosis rate in the SES group was 0% in all strata (versus 35%, 26%, and 20%, respectively, in the BS group). In-stent late loss was 0.01+/-0.25 versus 0.80+/-0.43 mm in stratum I, 0.01+/-0.38 versus 0.88+/-0.57 mm in stratum II, and -0.06+/-0.35 versus 0.74+/-0.57 mm in stratum III (SES versus BS). In SES, the minimal lumen diameter (MLD) remained unchanged (Delta -0.72 to 0.72 mm) in 97% of the lesions and increased (=late gain, DeltaMLD <-0.72 mm) in 3% of the lesions. Multivariate predictors for late loss were treatment allocation (P<0.001) and postprocedural MLD (P= 0.008). CONCLUSIONS: Sirolimus-eluting stents prevent neointimal proliferation and late lumen loss irrespective of the vessel diameter. The classic inverse relationship between vessel diameter and restenosis rate was seen in the bare stent group but not in the sirolimus-eluting stent group

Site preparation for Pinus establishment in south-eastern Queensland 1. Temporal changes in bulk density

In south-eastern Queensland, Australia, standard site preparation practices used for Pinus plantation establishment are mounding (bedding) on poorly drained soils and blade cultivation (subsurface, wing rip) on well-drained soils. This paper reports the impacts of both site preparation treatments on soil bulk density over time. Following site preparation, the extent of bulk density reduction and the nature of bulk density consolidation was affected by soil type, soil depth and the site preparation technique used. On high strength, hardsetting soils, bulk density reductions from both mounding and blade cultivation persisted throughout the 28-month period, and contrasted with non-hardsetting soils in the plantation estate, which consolidated more rapidly and had higher bulk densities relative to precultivation levels for the period 4-28 months following site preparation. The studies reported in this paper were the first in south-eastern Queensland to investigate the impact of site preparation for Pinus establishment on the nature and longevity of bulk density reductions. Previously, plantation managers assumed that positive site preparation impacts would be relatively short-lived, and therefore developed a prudential policy of planting Pinus seedlings immediately following site preparation. For the soils studied, delays of 2-4 months, and perhaps up to 6 months, between site preparation and planting would not compromise Pinus growth, but would assist management planning

Site preparation for Pinus establishment in south-eastern Queensland. 2. Effect of cultivation and cultivation width on growth

The standard site preparation practice used for Pinus plantation establishment on well-drained soils in south-eastern Queensland is blade (subsurface, wing rip) cultivation to a width of 2.0 m and a depth of 0.2 m. This operation requires high drawbar power and is difficult to achieve in high strength soils, or in soils where roots and stumps hinder progress of the blade through the soil. The aim of the study reported in this paper was to better define cultivation growth relationships for Pinus caribaea var. hondurensis plantations in order to determine if site preparation objectives could be achieved with a reduced cultivation effort. A highly significant 'soil type x cultivation' interaction was observed. In contrast to the growth responses observed on hardsetting soils, cultivation did not improve growth on non-hardsetting soils. There is an opportunity therefore to reduce reforestation site preparation costs by only cultivating soils that show a growth response. The cultivation response on hardsetting soils has increased throughout the study period, and is attributed to a reduction in soil penetration resistance. The response however shows diminishing gains with increasing cultivation widths. Blade cultivation widths of 1.2 m were found to capture 97% of the gains that could be expected from widths of 2.0 m. A significant 'family x soil penetration resistance' interaction was observed. An opportunity to increase plantation productivity by targeting better performing families to hardsetting soils is suggested

Using a New Odour-Baited Device to Explore Options for Luring and Killing Outdoor-Biting Malaria Vectors: A Report on Design and Field Evaluation of the Mosquito Landing Box.

Mosquitoes that bite people outdoors can sustain malaria transmission even where effective indoor interventions such as bednets or indoor residual spraying are already widely used. Outdoor tools may therefore complement current indoor measures and improve control. We developed and evaluated a prototype mosquito control device, the 'Mosquito Landing Box' (MLB), which is baited with human odours and treated with mosquitocidal agents. The findings are used to explore technical options and challenges relevant to luring and killing outdoor-biting malaria vectors in endemic settings. Field experiments were conducted in Tanzania to assess if wild host-seeking mosquitoes 1) visited the MLBs, 2) stayed long or left shortly after arrival at the device, 3) visited the devices at times when humans were also outdoors, and 4) could be killed by contaminants applied on the devices. Odours suctioned from volunteer-occupied tents were also evaluated as a potential low-cost bait, by comparing baited and unbaited MLBs. There were significantly more Anopheles arabiensis, An. funestus, Culex and Mansonia mosquitoes visiting baited MLB than unbaited controls (P<=0.028). Increasing sampling frequency from every 120 min to 60 and 30 min led to an increase in vector catches of up to 3.6 fold (P<=0.002), indicating that many mosquitoes visited the device but left shortly afterwards. Outdoor host-seeking activity of malaria vectors peaked between 7:30 and 10:30pm, and between 4:30 and 6:00am, matching durations when locals were also outdoors. Maximum mortality of mosquitoes visiting MLBs sprayed or painted with formulations of candidate mosquitocidal agent (pirimiphos-methyl) was 51%. Odours from volunteer occupied tents attracted significantly more mosquitoes to MLBs than controls (P<0.001). While odour-baited devices such as the MLBs clearly have potential against outdoor-biting mosquitoes in communities where LLINs are used, candidate contaminants must be those that are effective at ultra-low doses even after short contact periods, since important vector species such as An. arabiensis make only brief visits to such devices. Natural human odours suctioned from occupied dwellings could constitute affordable sources of attractants to supplement odour baits for the devices. The killing agents used should be environmentally safe, long lasting, and have different modes of action (other than pyrethroids as used on LLINs), to curb the risk of physiological insecticide resistance