What About the Children? - FDA's Response to Pediatric Drug Testing

The Federal Food and Drug Administration (FDA) has played a critical role in the protection of human subjects in research. Most recently, FDA enacted an interim final rule regarding protection of children in clinical investigations. FDA’s interim rule represents its most current policy on human subject protection. Current events illuminate FDA’s policies and how FDA has chosen to respond to debates over pediatric drug testing. This paper will provide a brief history of FDA’s participation in human subject protection. This paper will then focus on FDA’s policies for pediatric research, its interim rule, and how the interim rule relates to current events. Finally, this paper will make a comment about how FDA balances its competing duties of protecting the public but also of promoting research

Enhancement of superconductivity in NbN nanowires by negative electron-beam lithography with positive resist

We performed comparative experimental investigation of superconducting NbN nanowires which were prepared by means of positive-and negative electron-beam lithography with the same positive tone Poly-methyl-methacrylate (PMMA) resist. We show that nanowires with a thickness 4.9 nm and widths less than 100 nm demonstrate at 4.2 K higher critical temperature and higher density of critical and retrapping currents when they are prepared by negative lithography. Also the ratio of the experimental critical-current to the depairing critical current is larger for nanowires prepared by negative lithography. We associate the observed enhancement of superconducting properties with the difference in the degree of damage that nanowire edges sustain in the lithographic process. A whole range of advantages which is offered by the negative lithography with positive PMMA resist ensures high potential of this technology for improving performance metrics of superconducting nanowire singe-photon detectors

Metaheuristics for the Vehicle Routing Problem with Loading Constraints

We consider a combination of the capacitated vehicle routing problem and a class of additional loading constraints involving a parallel machine scheduling problem. The work is motivated by a real-world transportation problem occurring to a wood-products retailer, which delivers its products to a number of customers in a specific region. We solve the problem by means of two different metaheuristics algorithms: a Tabu Search and an Ant Colony Optimization. Extensive computational results are given for both algorithms, on instances derived from the vehicle routing literature and on real-world instances

Timing jitter in photon detection by straight superconducting nanowires: Effect of magnetic field and photon flux

We studied the effect of the external magnetic field and photon flux on timing jitter in photon detection by straight superconducting NbN nanowires. At two wavelengths 800 and 1560 nm, statistical distribution in the appearance time of the photon count exhibits Gaussian shape at small times and exponential tail at large times. The characteristic exponential time is larger for photons with smaller energy and increases with external magnetic field while variations in the Gaussian part of the distribution are less pronounced. Increasing photon flux drives the nanowire from quantum detection mode to the bolometric mode that averages out fluctuations of the total number of nonequilibrium electrons created by the photon and drastically reduces jitter. The difference between Gaussian parts of distributions for these two modes provides the measure for the electron-number fluctuations. Corresponding standard deviation increases with the photon energy. We show that the two-dimensional hot-spot detection model explains qualitatively the effect of magnetic field

Proximity effect model of ultra-narrow NbN strips

We show that narrow superconducting strips in superconducting (S) and normal (N) states are universally described by the model presenting them as lateral NSN proximity systems in which the superconducting central band is sandwiched between damaged edge-bands with suppressed superconductivity.The width of the superconducting band was experimentally determined from the value of magnetic field at which the band transits from the Meissner state to the static vortex state. Systematic experimental study of 4.9 nm thick NbN strips with widths in the interval from 50 nm to 20 ${\mu}$m, which are all smaller than the Pearl's length, demonstrates gradual evolution of the temperature dependence of the critical current with the change of the strip width

Carbohydrate utilization in obese subjects after an oral load of 100 g naturally-labelled [13C] glucose

1. Total carbohydrate (CHO) and ingested glucose oxidation was measured in five obese subjects with normal glucose tolerance after an oral load of 100g naturally-labelled [13C]glucose using indirect calorimetry and mass spectrometry respectively. 2. CHO utilization rate (107 ± 14 mg/min in the post-absorptive state) increased 30 min after the glucose load to reach a plateau (245±25 mg/min) between 90 and 120 min. It then decreased to basal values at 330 min. Cumulative CHO oxidation over 480 min was 66±7 g and the CHO oxidized above basal levels was 26 ± 7g. 3. Enrichment of expired carbon dioxide with 13c began at 45 min and maximum values were observed between 210 and 300 min. At 480 min, cumulative oxidation of the ingested glucose was 24± 2 g. 4. Compared with controls, the obese subjects exhibit an impairment of CHO utilization which precedes glucose intolerance. This impairment can be explained by an increased availability of free fatty acids which favours lipid oxidation at the expense of ingested [13C]glucose oxidatio