EFFECT OF PARTIAL REPLACEMENT OF MONOSODIUM GLUTAMATE BY 5΄-INOSINE MONOPHOSPHATE ON THE FERTILITY OF MALE RATS

This work aimed to study the effect of partial replacement of monosodium glutamate (MSG) by 5΄ inosine monophosphate (5΄-IMP) on the fertility of male rats after oral administration for 90 days. Before the biological treatment, a half amount of MSG as flavor enhancer in chicken burger was replaced by 5´IMP. The sensory assessment of cocked chicken burger confirmed that this used mixture (1:1 w/w) had a synergistic effect and led to improve the flavor intensity compared to that with MSG. Treatments were applied by stomach tube (mg/kg BW); (i) MSG, [60 for adult; 30 for weaned rats]; (ii) Mixture (1:1; w/w) of MSG and 5΄-IMP [30:30 for adults; 15:15 for weaned rats] and (iii) 5΄-IMP [30 for adult; 15 for weaned rats]. Body weight gain (BWG%) and weight of some reproductive organs including testes, prostate, cauda epididymes and seminal vesicles were measured. Serum testosterone and interstitial cell-stimulating hormone (ICSH) and seminal fructose content were assayed. Spermatozoa activity and the histology of reproductive organs were also studied in adult and weaned male rat groups. Severe negative effects on most studied parameters were demonstrated in MSG-groups, where the lowest fructose content in prostate, testosterone levels and spermatozoal activities were recorded. Reduction in the weight of cauda epididymes and testes was recorded in MSG-treated weaned rats. Histologically, all studied reproductive organs were dramatically affected by MSG-treatment. Considerable enhancements in the studied parameters and normal histological profiles were obtained due to the partial replacement of MSG by 5΄-IMP. In conclusion, 5΄-IMP has a potential protective effect against MSG-hazards in reproductive organs

Ruptured cardiac hydatid cyst as a rare cause of acute extremity ischemia: A case presentation

Echinococcosis, also known as a Hydatic cyst (HC), is a chronic parasitic disease that is prevalent in countries where people consume infected grazing animal meat. The heart is involved in 0.5% to 2% of all hydatid cysts. The best diagnostic method for cardiac HC is echocardiography. In addition to radiological examinations, HC diagnosis is dependent on serological reactions such as the Cassoni test and ELISA for Echinococcus multilocularis. Rupture of cardiac HC from the left ventricle is an uncommon but potentially fatal consequence that results in ischemia by numerous emboli. We report a case of a 31year old Nepali male who presented in the emergency room (ER) with anaphylactic shock and lower and upper extremity ischemia. The patient was resuscitated in ER and then shifted to the Intensive Care Unit (ICU). The reperfusion of the lower and upper extremities was achieved after Fogarty embolectomy. To evaluate the source of the emboli, echocardiography was carried out, and a remnant of the ruptured cyst on the left ventricular free wall was found. The histopathology report came consistent with the HC. Accordingly, the patient received Albendazole. He preferred to seek a second opinion regarding the decided cardiac surgery in his home country Nepal