Requirements for Topology in 3D GIS

Topology and its various benefits are well understood within the context of 2D Geographical Information Systems. However, requirements in three-dimensional (3D) applications have yet to be defined, with factors such as lack of users' familiarity with the potential of such systems impeding this process. In this paper, we identify and review a number of requirements for topology in 3D applications. The review utilises existing topological frameworks and data models as a starting point. Three key areas were studied for the purposes of requirements identification, namely existing 2D topological systems, requirements for visualisation in 3D and requirements for 3D analysis supported by topology. This was followed by analysis of application areas such as earth sciences and urban modelling which are traditionally associated with GIS, as well as others including medical, biological and chemical science. Requirements for topological functionality in 3D were then grouped and categorised. The paper concludes by suggesting that these requirements can be used as a basis for the implementation of topology in 3D. It is the aim of this review to serve as a focus for further discussion and identification of additional applications that would benefit from 3D topology. © 2006 The Authors. Journal compilation © 2006 Blackwell Publishing Ltd

Dwarna : a blockchain solution for dynamic consent in biobanking

Dynamic consent aims to empower research partners and facilitate active participation in the research process. Used within the context of biobanking, it gives individuals access to information and control to determine how and where their biospecimens and data should be used. We present Dwarna—a web portal for ‘dynamic consent’ that acts as a hub connecting the different stakeholders of the Malta Biobank: biobank managers, researchers, research partners, and the general public. The portal stores research partners’ consent in a blockchain to create an immutable audit trail of research partners’ consent changes. Dwarna’s structure also presents a solution to the European Union’s General Data Protection Regulation’s right to erasure—a right that is seemingly incompatible with the blockchain model. Dwarna’s transparent structure increases trustworthiness in the biobanking process by giving research partners more control over which research studies they participate in, by facilitating the withdrawal of consent and by making it possible to request that the biospecimen and associated data are destroyed.peer-reviewe

GNSS Shadow Matching: The Challenges Ahead

GNSS shadow matching is a new technique that uses 3D mapping to improve positioning accuracy in dense urban areas from tens of meters to within five meters, potentially less. This paper presents the first comprehensive review of shadow matching’s error sources and proposes a program of research and development to take the technology from proof of concept to a robust, reliable and accurate urban positioning product. A summary of the state of the art is also included. Error sources in shadow matching may be divided into six categories: initialization, modelling, propagation, environmental complexity, observation, and algorithm approximations. Performance is also affected by the environmental geometry and it is sometimes necessary to handle solution ambiguity. For each error source, the cause and how it impacts the position solution is explained. Examples are presented, where available, and improvements to the shadow-matching algorithms to mitigate each error are proposed. Methods of accommodating quality control within shadow matching are then proposed, including uncertainty determination, ambiguity detection, and outlier detection. This is followed by a discussion of how shadow matching could be integrated with conventional ranging-based GNSS and other navigation and positioning technologies. This includes a brief review of methods to enhance ranging-based GNSS using 3D mapping. Finally, the practical engineering challenges of shadow matching are assessed, including the system architecture, efficient GNSS signal prediction and the acquisition of 3D mapping data

Inheritance Law and Investment in Family Firms

Entrepreneurs may be legally bound to bequeath a minimal stake to non-controlling heirs. The size of this stake can reduce investment in family firms, by reducing the future income they can pledge to external financiers. Using a purpose-built indicator of the permissiveness of inheritance law and data for 10,004 firms from 38 countries in 1990-2006, we find that stricter inheritance law is associated with lower investment in family firms, but does not affect investment in non-family firms. Moreover, as the model predicts, inheritance law affects investment only in family firms that experience a succession

Diagnosis and outcome of oesophageal Crohn's disease

BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement. METHODS: We collected cases through a retrospective multicentre European Crohn's and Colitis Organisation CONFER [COllaborative Network For Exceptionally Rare case reports] project. Clinical data were recorded in a standardized case report form. RESULTS: A total of 40 patients were reported [22 males, mean (±SD, range) age at oesophageal CD diagnosis: 25 (±13.3, 10-71) years and mean time of follow-up: 67 (±68.1, 3-240) months]. Oesophageal involvement was established at CD diagnosis in 26 patients (65%) and during follow-up in 14. CD was exclusively located in the oesophagus in 2 patients. Thirteen patients (32.2%) were asymptomatic at oesophageal disease diagnosis. Oesophageal strictures were present in 5 patients and fistulizing oesophageal disease in one. Eight patients exhibited granulomas on biopsies. Proton-pump inhibitors (PPIs) were administered in 37 patients (92.5%). Three patients underwent endoscopic dilation for symptomatic strictures and none oesophageal-related surgery. Diagnosis in pre-established CD resulted in treatment modifications in 9/14 patients. Clinical remission of oesophageal disease was seen in 33/40 patients (82.5%) after a mean time of 7 (±5.6, 1-18) months. Follow-up endoscopy was performed in 29/40 patients and 26/29 (89.7%) achieved mucosal healing. CONCLUSION: In this case series the endoscopic and histologic characteristics of isolated oesophageal CD were similar to those reported in other sites of involvement. Treatment was primarily conservative, with PPIs administered in the majority of patients and modifications in pre-existing IBD-related therapy occurring in two thirds of them. Clinical and endoscopic remission was achieved in more than 80% of the patients.info:eu-repo/semantics/publishedVersio

Intelligent GNSS Positioning using 3D Mapping and Context Detection for Better Accuracy in Dense Urban Environments

Conventional GNSS positioning in dense urban areas can exhibit errors of tens of meters due to blockage and reflection of signals by the surrounding buildings. Here, we present a full implementation of the intelligent urban positioning (IUP) 3D-mapping-aided (3DMA) GNSS concept. This combines conventional ranging-based GNSS positioning enhanced by 3D mapping with the GNSS shadow-matching technique. Shadow matching determines position by comparing the measured signal availability with that predicted over a grid of candidate positions using 3D mapping. Thus, IUP uses both pseudo-range and signal-to-noise measurements to determine position. All algorithms incorporate terrain-height aiding and use measurements from a single epoch in time. Two different 3DMA ranging algorithms are presented, one based on least-squares estimation and the other based on computing the likelihoods of a grid of candidate position hypotheses. The likelihood-based ranging algorithm uses the same candidate position hypotheses as shadow matching and makes different assumptions about which signals are direct line-of-sight (LOS) and non-line-of-sight (NLOS) at each candidate position. Two different methods for integrating likelihood-based 3DMA ranging with shadow matching are also compared. In the position-domain approach, separate ranging and shadow-matching position solutions are computed, then averaged using direction-dependent weighting. In the hypothesis-domain approach, the candidate position scores from the ranging and shadow matching algorithms are combined prior to extracting a joint position solution. Test data was recorded using a u-blox EVK M8T consumer-grade GNSS receiver and a HTC Nexus 9 tablet at 28 locations across two districts of London. The City of London is a traditional dense urban environment, while Canary Wharf is a modern environment. The Nexus 9 tablet data was recorded using the Android Nougat GNSS receiver interface and is representative of future smartphones. Best results were obtained using the likelihood-based 3DMA ranging algorithm and hypothesis-based integration with shadow matching. With the u-blox receiver, the single-epoch RMS horizontal (i.e., 2D) error across all sites was 4.0 m, compared to 28.2 m for conventional positioning, a factor of 7.1 improvement. Using the Nexus tablet, the intelligent urban positioning RMS error was 7.0 m, compared to 32.7 m for conventional GNSS positioning, a factor of 4.7 improvement. An analysis of processing and data requirements shows that intelligent urban positioning is practical to implement in real-time on a mobile device or a server. Navigation and positioning is inherently dependent on the context, which comprises both the operating environment and the behaviour of the host vehicle or user. No single technique is capable of providing reliable and accurate positioning in all contexts. In order to operate reliably across different contexts, a multi-sensor navigation system is required to detect its operating context and reconfigure the techniques accordingly. Specifically, 3DMA GNSS should be selected when the user is in a dense urban environment, not indoors or in an open environment. Algorithms for detecting indoor and outdoor context using GNSS measurements and a hidden Markov model are described and demonstrated

The position profiles of order cancellations in an emerging stock market

Order submission and cancellation are two constituent actions of stock trading behaviors in order-driven markets. Order submission dynamics has been extensively studied for different markets, while order cancellation dynamics is less understood. There are two positions associated with a cancellation, that is, the price level in the limit-order book (LOB) and the position in the queue at each price level. We study the profiles of these two order cancellation positions through rebuilding the limit-order book using the order flow data of 23 liquid stocks traded on the Shenzhen Stock Exchange in the year 2003. We find that the profiles of relative price levels where cancellations occur obey a log-normal distribution. After normalizing the relative price level by removing the factor of order numbers stored at the price level, we find that the profiles exhibit a power-law scaling behavior on the right tails for both buy and sell orders. When focusing on the order cancellation positions in the queue at each price level, we find that the profiles increase rapidly in the front of the queue, and then fluctuate around a constant value till the end of the queue. These profiles are similar for different stocks. In addition, the profiles of cancellation positions can be fitted by an exponent function for both buy and sell orders. These two kinds of cancellation profiles seem universal for different stocks investigated and exhibit minor asymmetry between buy and sell orders. Our empirical findings shed new light on the order cancellation dynamics and pose constraints on the construction of order-driven stock market models.Comment: 17 pages, 6 figures and 6 table