The malleable brain: plasticity of neural circuits and behavior: A review from students to students

One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation (LTP) and long-term depression (LTD) respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by LTP and LTD, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity.Fil: Schaefer, Natascha. University of Wuerzburg; AlemaniaFil: Rotermund, Carola. University of Tuebingen; AlemaniaFil: Blumrich, Eva Maria. Universitat Bremen; AlemaniaFil: Lourenco, Mychael V.. Universidade Federal do Rio de Janeiro; BrasilFil: Joshi, Pooja. Robert Debre Hospital; FranciaFil: Hegemann, Regina U.. University of Otago; Nueva ZelandaFil: Jamwal, Sumit. ISF College of Pharmacy; IndiaFil: Ali, Nilufar. Augusta University; Estados UnidosFil: García Romero, Ezra Michelet. Universidad Veracruzana; MéxicoFil: Sharma, Sorabh. Birla Institute of Technology and Science; IndiaFil: Ghosh, Shampa. Indian Council of Medical Research; IndiaFil: Sinha, Jitendra K.. Indian Council of Medical Research; IndiaFil: Loke, Hannah. Hudson Institute of Medical Research; AustraliaFil: Jain, Vishal. Defence Institute of Physiology and Allied Sciences; IndiaFil: Lepeta, Katarzyna. Polish Academy of Sciences; ArgentinaFil: Salamian, Ahmad. Polish Academy of Sciences; ArgentinaFil: Sharma, Mahima. Polish Academy of Sciences; ArgentinaFil: Golpich, Mojtaba. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Nawrotek, Katarzyna. University Of Lodz; ArgentinaFil: Paid, Ramesh K.. Indian Institute of Chemical Biology; IndiaFil: Shahidzadeh, Sheila M.. Syracuse University; Estados UnidosFil: Piermartiri, Tetsade. Universidade Federal de Santa Catarina; BrasilFil: Amini, Elham. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Wilson, Yvette. University of Melbourne; AustraliaFil: Adeniyi, Philip A.. Afe Babalola University; NigeriaFil: Datusalia, Ashok K.. National Brain Research Centre; IndiaFil: Vafadari, Benham. Polish Academy of Sciences; ArgentinaFil: Saini, Vedangana. University of Nebraska; Estados UnidosFil: Suárez Pozos, Edna. Instituto Politécnico Nacional; MéxicoFil: Kushwah, Neetu. Defence Institute of Physiology and Allied Sciences; IndiaFil: Fontanet, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Turner, Anthony J.. University of Leeds; Reino Unid

The value of satellite remote sensing soil moisture data and the DISPATCH algorithm in irrigation fields

Soil moisture measurements are needed in a large number of applications such as hydro-climate approaches, watershed water balance management and irrigation scheduling. Nowadays, different kinds of methodologies exist for measuring soil moisture. Direct methods based on gravimetric sampling or time domain reflectometry (TDR) techniques measure soil moisture in a small volume of soil at few particular locations. This typically gives a poor description of the spatial distribution of soil moisture in relatively large agriculture fields. Remote sensing of soil moisture provides widespread coverage and can overcome this problem but suffers from other problems stemming from its low spatial resolution. In this context, the DISaggregation based on Physical And Theoretical scale CHange (DISPATCH) algorithm has been proposed in the literature to downscale soil moisture satellite data from 40 to 1&thinsp;km resolution by combining the low-resolution Soil Moisture Ocean Salinity (SMOS) satellite soil moisture data with the high-resolution Normalized Difference Vegetation Index (NDVI) and land surface temperature (LST) datasets obtained from a Moderate Resolution Imaging Spectroradiometer (MODIS) sensor. In this work, DISPATCH estimations are compared with soil moisture sensors and gravimetric measurements to validate the DISPATCH algorithm in an agricultural field during two different hydrologic scenarios: wet conditions driven by rainfall events and wet conditions driven by local sprinkler irrigation. Results show that the DISPATCH algorithm provides appropriate soil moisture estimates during general rainfall events but not when sprinkler irrigation generates occasional heterogeneity. In order to explain these differences, we have examined the spatial variability scales of NDVI and LST data, which are the input variables involved in the downscaling process. Sample variograms show that the spatial scales associated with the NDVI and LST properties are too large to represent the variations of the average soil moisture at the site, and this could be a reason why the DISPATCH algorithm does not work properly in this field site.</p

Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections

During the past year, a group has argued that unsafe injections are a major if not the main mode of HIV-1 transmission\ud in sub-Saharan Africa. We review the main arguments used to question the epidemiological interpretations on the lead\ud role of unsafe sex in HIV-1 transmission, and conclude there is no compelling evidence that unsafe injections are a\ud predominant mode of HIV-1 transmission in sub-Saharan Africa. Conversely, though there is a clear need to eliminate\ud all unsafe injections, epidemiological evidence indicates that sexual transmission continues to be by far the major\ud mode of spread of HIV-1 in the region. Increased efforts are needed to reduce sexual transmission of HIV-1

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the host’s protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly, slow healers had deeper metabolic and coagulation defects at the start of antibiotic therapy. In addition to providing novel insight into Buruli ulcer pathogenesis, our study therefore identifies a unique proteomic signature for this disease

Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa.

Human Immunodeficiency Virus-1/AIDS and Schistosoma mansoni are widespread in sub-Saharan Africa and co-infection occurs commonly. Since the early 1990s, it has been suggested that the two infections may interact and potentiate the effects of each other within co-infected human hosts. Indeed, S. mansoni infection has been suggested to be a risk factor for HIV transmission and progression in Africa. If so, it would follow that mass deworming could have beneficial effects on HIV-1 transmission dynamics. The epidemiology of HIV in African countries is changing, shifting from urban to rural areas where the prevalence of Schistosoma mansoni is high and public health services are deficient. On the other side, the consequent pathogenesis of HIV-1/S. mansoni co-infection remains unknown. Here we give an account of the epidemiology of HIV-1 and S. mansoni, discuss co-infection and possible biological causal relationships between the two infections, and the potential impact of praziquantel treatment on HIV-1 viral loads, CD4+ counts and CD4+/CD8+ ratio. Our review of the available literature indicates that there is evidence to support the hypothesis that S. mansoni infections can influence the replication of the HIV-1, cell-to-cell transmission, as well as increase HIV progression as measured by reduced CD4+ T lymphocytes counts. If so, then deworming of HIV positive individuals living in endemic areas may impact on HIV-1 viral loads and CD4+ T lymphocyte counts.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

A Qualitative Exploration of Community Ownership of a Maternity Waiting Home Model in Rural Zambia

Context Ownership is an important construct of sustainability for community-based health programming, though it is often not clearly defined or measured. We implemented and evaluated a community-driven maternity waiting home (MWH) model in rural Zambia. We engaged stakeholders at all levels and provided intensive mentorship to an MWH governance committee comprised of community-selected members. We then examined how different stakeholders perceive community ownership of the MWH. Methods We conducted 42 focus group discussions with community stakeholders (pregnant women, fathers, elders, and community health volunteers) and 161 in-depth interviews with MWH stakeholders (health facility staff, district health officials, and MWH governance committee and management unit members) at multiple time-points over 24 months. We conducted a content analysis and triangulated findings to understand community ownership of the MWH and observe changes in perceptions of ownership over time. Results Community members’ perceptions of ownership were related to their ability to use the MWH and a responsibility toward its success. Community and MWH stakeholders described increasingly more specific responsibilities over time. Governance committee and management unit members perceived their ability to represent the community as a crucial component of their role. Multiple respondent types saw collaboration between the governance committee and the health facility staff as key to allowing the MWH to meet its goal of serving the community. Conclusion The perceptions of community ownership evolved as the intervention became more established. Use of the MWH, and clear understanding of roles and responsibilities in management of the MWH, seemed to foster feelings of community ownership. To improve the sustainability of community-based maternal and child health programs, interventions should be accessible to target communities and clear roles should be established among stakeholders

Diagnósticos enfermeros en UFISS, UGA, Traumatología y CIR.

In 2006, after the addition of a new nurse in UFISS (Social-Sanitary Functional Interdisciplinary Unit), is detected the need of a common language for all nurses with which to conduct a data collection for the nursing reports. The aim of this study is to know the main nursing diagnoses in UFISS, Geriatrics, Traumatology and Surgery units, using the NANDA (North American Nursing Diagnosis Association) nursing diagnostic terminology. We performed a retrospective study of all the medical reports at UFISS in 2006, a prospective study of all medical reports at Geriatrics and geriatric patients at Traumatology and Surgery in various periods between 2008 and 2009. According to the results, the use of a validated method like NANDA diagnoses, has enabled to nurses to identify common altered needs and after that, to define Nursing Diagnoses and develop the optimal care plan for the patientIntroducción: La utilización de un método validado, ha permitido detectar las necesidades alteradas en relación a su etiología, definiendo los DdE (Diagnósticos de Enfermería) (3).La utilización de la Taxonomía NANDA 2 asegura la definición de la respuesta humana a un problema tanto dentro del marco profesional como jurídico, así mismo permite un lenguaje común en la práctica enfermera (6).Objetivos. Identificar los DdE más prevalentes en la población atendida por la UFISS (Unidad Funcional Interdisciplinar Socio-Sanitaria), UGA (Unidad de Geriatría Aguda), TRAUMATOLOGÍA y CIRUGÍA de la FHAG (Fundación Hospital Asilo de Granollers) utilizando la taxonomía NANDA.Métodos.UFFIS. Se estudian retrospectivamente todas las historias de la UFISS del año 2006. (674 consultas, entrando en estudio N= 390 estudiadas).Se estudian prospectivamente:COT (Cirugía Ortopédica Traumatológica). 24 pacientes geriátricos de la unidad de trauma ingresados durante los meses de Agosto-Septiembre 2008UGA. 49 pacientes ingresados durante los meses de Septiembre-Diciembre 2008CIR. 36 pacientes ingresados en mayo 2009.Valoración paciente: Abordaje Bio-Psico-Social (Entrevista enfermera al paciente y al cuidador principal).Funcional (Barthel). Instrumentales (Lawton). Cognitivo (Pfeiffer). Riesgo de úlceras (EMINA). Dolor (EVA)Resultados.UFISS: Se detectan 18 diagnósticos, como los más prevalentes valorados en la UFISS,COT: Se detectan 26 diagnósticos, 16 son comunes a los recogidos por la enfermera de la UFISS, los 10 restantes son los específicos detectados en el paciente orto geriátrico:UGA: Se detectan 30 diagnósticos, de los cuales 18 son comunes a la UFISS y los 12 restantes son específicos en el paciente geriátrico.CIR: Se detectan alrededor de 50 diagnósticos; pendiente tabulación final.Conclusiones: Se han definido los diagnósticos más prevalentes determinando los comunes a las diferentes áreas asistenciales. Dado que en nuestra institución la formación es mayoritariamente básica, con este estudio hemos conseguido: 1) difundir el lenguaje NANDA, 2) asegurar el dominio de estos diagnósticos, 3) que el profesional trabaje de forma más segura utilizando un lenguaje validado y entendible y 4) orientar a la futura implantación informática

European traditional tomatoes galore: A result of farmers' selection of a few diversity-rich loci

A comprehensive collection of 1254 tomato accessions, corresponding to European traditional and modern varieties, early domesticated varieties, and wild relatives, was analyzed by genotyping by sequencing. A continuous genetic gradient between the traditional and modern varieties was observed. European traditional tomatoes displayed very low genetic diversity, with only 298 polymorphic loci (95% threshold) out of 64 943 total variants. European traditional tomatoes could be classified into several genetic groups. Two main clusters consisting of Spanish and Italian accessions showed higher genetic diversity than the remaining varieties, suggesting that these regions might be independent secondary centers of diversity with a different history. Other varieties seem to be the result of a more recent complex pattern of migrations and hybridizations among the European regions. Several polymorphic loci were associated in a genome-wide association study with fruit morphological traits in the European traditional collection. The corresponding alleles were found to contribute to the distinctive phenotypic characteristic of the genetic varietal groups. The few highly polymorphic loci associated with morphological traits in an otherwise a low-diversity population suggests a history of balancing selection, in which tomato farmers likely maintained the morphological variation by inadvertently applying a high selective pressure within different varietal types