Prevention of obesity : weighing ethical arguments

Taxes on unhealthy food, limits to commercial advertising, a ban on chocolate drink at schools, or compulsory physical exercise for obese employees: efforts to counter the rise in overweight and obesity sometimes rais

Бухгалтерский и налоговый учет основных средств

Цель статьи: обосновать существующие различия в бухгалтерском и налоговом учете основных средств

Economic inequalities in the effectiveness of a primary care intervention for depression and suicidal ideation.

BACKGROUND: Economic disadvantage is associated with depression and suicide. We sought to determine whether economic disadvantage reduces the effectiveness of depression treatments received in primary care. METHODS: We conducted differential-effects analyses of the Prevention of Suicide in Primary Care Elderly: Collaborative Trial, a primary-care-based randomized, controlled trial for late-life depression and suicidal ideation conducted between 1999 and 2001, which included 514 patients with major depression or clinically significant minor depression. RESULTS: The intervention effect, defined as change in depressive symptoms from baseline, was stronger among persons reporting financial strain at baseline (differential effect size = -4.5 Hamilton Depression Rating Scale points across the study period [95% confidence interval = -8.6 to -0.3]). We found similar evidence for effect modification by neighborhood poverty, although the intervention effect weakened after the initial 4 months of the trial for participants residing in poor neighborhoods. There was no evidence of substantial differences in the effectiveness of the intervention on suicidal ideation and depression remission by economic disadvantage. CONCLUSIONS: Economic conditions moderated the effectiveness of primary-care-based treatment for late-life depression. Financially strained individuals benefited more from the intervention; we speculate this was because of the enhanced treatment management protocol, which led to a greater improvement in the care received by these persons. People living in poor neighborhoods experienced only temporary benefit from the intervention. Thus, multiple aspects of economic disadvantage affect depression treatment outcomes; additional work is needed to understand the underlying mechanisms

What Factors are Associated with Flourishing? Results from a Large Representative National Sample

Flourishing is the ultimate end-state in psychology and a key-concept in the field of positive psychology research. Flourishers are those individuals with both high levels of hedonic well-being and eudaimonic well-being. Although many researchers have focused on one or another of these domains, only a few have investigated the comprehensive state of flourishing. The purpose of this study was to examine the prevalence of flourishing and its association with socio-demographics, personality traits and situational factors. This study used data from the second wave of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a national representative sample of adults in The Netherlands (n = 5303; 2010–2012). Findings were compared to having either high hedonic well-being or high eudaimonic well-being. Results showed that 37 % of the respondents were flourishers, mainly characterized by high levels of conscientiousness and extraversion and low levels of neuroticism. The situational factors of social support and positive life-events were significantly associated with flourishing when the analysis was controlled for socio-demographics and personality traits. Flourishing was most distinct from high hedonic well-being and showed parallelism with high eudaimonic well-being. More research is needed to establish a preferred flourishing instrument with validated cut-off points for flourishing and to understand the processes of situational factors that may underlie the promotion of flourishing. We recommend longitudinal designs and experience sampling studies to investigate the unique and modifiable predictors of flourishing. In addition, future research should include intervention studies that examine through which hedonic and eudaimonic pathways flourishing can be achieve

Van de grond : verkenning mogelijkheden voor het inzetten van publieke grond voor maatschappelijke doelen in Eemland

Eemland is één van de beste weidevogelgebieden van Nederland. Veel boeren doen al aan agrarisch natuurbeheer, maar de groei is eruit. Agrarische natuur- en landschapsvereniging Ark & Eemlandschap zou graag meer in handen hebben dan de subsidieregeling SNL om boeren te stimuleren om mee te doen. Zij ziet in grondgebruiksrecht een potentiële extra beloning, juist omdat grond schaars is. Hoge grondprijzen en een lage grondmobiliteit zijn typische problemen van stadsrandgebieden zoals Eemland. Ark & Eemlandschap zou grond in bezit bij overheden en maatschappelijke organisaties graag inzetten om extra groenblauwe diensten te stimuleren. Voor het verdelen van de publieke grond kan worden gedacht aan een grondbank als organisatievorm. Ark & Eemlandschap wil namelijk met de grondbank publieke grond in pacht uitgeven, in ruil voor extra agrarisch natuurbeheer (of klompenpaden) op grond die de boer al in gebruik of in bezit heeft. Op deze manier wil Ark & Eemlandschap boeren verleiden om bijvoorbeeld op voor de weidevogel gunstige plekken agrarisch natuurbeheer te gaan doen

Composition of the Survival Motor Neuron (SMN) complex in Drosophila melanogaster

Spinal Muscular Atrophy (SMA) is caused by homozygous mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein has a well-characterized role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), core components of the spliceosome. SMN is part of an oligomeric complex with core binding partners, collectively called Gemins. Biochemical and cell biological studies demonstrate that certain Gemins are required for proper snRNP assembly and transport. However, the precise functions of most Gemins are unknown. To gain a deeper understanding of the SMN complex in the context of metazoan evolution, we investigated its composition in Drosophila melanogaster. Using transgenic flies that exclusively express Flag-tagged SMN from its native promoter, we previously found that Gemin2, Gemin3, Gemin5, and all nine classical Sm proteins, including Lsm10 and Lsm11, co-purify with SMN. Here, we show that CG2941 is also highly enriched in the pulldown. Reciprocal co-immunoprecipitation reveals that epitope-tagged CG2941 interacts with endogenous SMN in Schneider2 cells. Bioinformatic comparisons show that CG2941 shares sequence and structural similarity with metazoan Gemin4. Additional analysis shows that three other genes (CG14164, CG31950 and CG2371) are not orthologous to Gemins 6-7-8, respectively, as previously suggested. In D.melanogaster, CG2941 is located within an evolutionarily recent genomic triplication with two other nearly identical paralogous genes (CG32783 and CG32786). RNAi-mediated knockdown of CG2941 and its two close paralogs reveals that Gemin4 is essential for organismal viability

Happy life expectancy associated with various mental disorders

How detrimental are mental disorders? One way to answer that question is to consider the effects on happiness. We analysed a representative sample (N = 7076) of the Dutch population, who were asked how often they had felt happy during the past four weeks. Mental disorders were assessed using the Composite International Diagnostic Interview. It turns out that the lowest levels of happiness are almost the exclusive domain of people with (a history of) mental disorders. The total loss of happy life years due to mental disorders is 36.6 million for the Netherlands

Erasmus Mundus Master of Bioethics: a case for an effective model for international bioethics education

Designing bioethics curriculum for international postgraduate students is a challenging task. There are at least two main questions, which have to be resolved in advance: (1) what is a purpose of a particular teaching program and (2) how to respectfully arrange a classroom for students coming from different cultural and professional backgrounds. In our paper we analyze the case of the Erasmus Mundus Master of Bioethics program and provide recommendations for international bioethics education. In our opinion teaching bioethics to postgraduate international students goes beyond curriculum. It means that such a program requires not only well-defined goals, including equipping students with necessary skills and knowledge, but also it should first and foremost facilitate positive group dynamics among students and enables them to engage in dialogue to learn from one another

Тактика лечения эректильной дисфункции у мужчин без партнерши

Обосновывается актуальность проблемы оказания помощи мужчинам с эректильной дисфункцией, не имеющим сексуальной партнерши. Описаны предложенные автором подходы к коррекции нарушения сексуального здоровья мужчин и лечебные тактики.The importance of the issue of rendering the aid to the men with erectile dysfunction who do not have a female partner is substantiated. The author describes the original approaches to correction of the sexual health in the men and therapeutic tactics