Mercury in the environs of the north slope of Alaska

The analysis of Greenland ice suggests that the flux of mercury from the continents to the atmosphere has increased in recent times, perhaps partly as a result of the many of man’s activities that effect an alteration of terrestrial surfaces. Upon the exposure of fresh crustal matter, the natural outgassing of mercury vapor from the earth’s surface could be enhanced. Accordingly, mercury was measured in a variety of environmental materials gathered from the North Slope of Alaska to provide background data prior to the anticipated increase of activity in this environment. The materials were collected during the U. S. Coast Guard WEBSEC 72-73 cruises as well as through the facilities provided by Naval Arctic Research Laboratory in the spring of 1973. The method of measurement depended upon radioactivation of mercury with neutrons and the subsequent quantification of characteristic gamma radiations after radiochemical purification. Mercury concentrations in seawater at several locations in the vicinity of 151°W, 71°N averaged 20 parts per trillion. The waters from all stations east of this location showed a significantly smaller concentration. This difference may relate to penetration o f Bering- Chukchi Sea water into the southern Beaufort Sea to 151°W. Marine sediments on the shelf and slope between 143°W and 153°W contained about 100 parts per billion mercury, except for those on the continental shelf between Barter Island and the Canning River, where the concentration was less than half this value. These results are consistent with sediment input from the respective rivers when their mercury content and mineralogy are considered. The mercury content of river waters was 18 ppt and in reasonable agreement with the average of snow samples (13 ppt). The burden of mercury in plankton was 37 ppb.This work was supported by the office of Naval Research under grant N R 083-290

An in situ instrument for planar O2 optode measurements at benthic interfaces

A new in situ instrument for two‐dimensional mapping of oxygen in coastal sediments is presented. The measuring principle is described, and potential mechanical disturbances, solute and particle smearing associated with the measurements, and calibration routines are evaluated. The first in situ measurements obtained in two different benthic communities are presented. In a shallow photosynthetic sediment (1 m of water depth), an extensive horizontal and temporal variation in the O2 distribution caused by benthic photosynthesis and irrigating fauna was resolved. Repetitive planar optode measurements performed along a transect in central Øresund, Denmark (17 m of water depth) revealed a positive correlation between the apparent O2 penetration depths (OP) measured with a lateral distance <5.0 mm, whereas OP measured with a larger horizontal distance (up to 50 m) were not correlated. Consequently, the OP varied in patches with a characteristic size of 5.0 mm. The instrument described is a powerful new tool for in situ characterization of spatiotemporal variations in O2 distributions within benthic communities. The instrument can be adapted for use at full ocean depths, e.g., on deep‐sea landers or remote operating vehicles

Uniformity in the Wiener-Wintner theorem for nilsequences

We prove a uniform extension of the Wiener-Wintner theorem for nilsequences due to Host and Kra and a nilsequence extension of the topological Wiener-Wintner theorem due to Assani. Our argument is based on (vertical) Fourier analysis and a Sobolev embedding theorem.Comment: v3: 18 p., proof that the cube construction produces compact homogeneous spaces added, measurability issues in the proof of Theorem 1.5 addressed. We thank the anonymous referees for pointing out these gaps in v

Cosmological implications of the KATRIN experiment

The upcoming Karlsruhe Tritium Neutrino (KATRIN) experiment will put unprecedented constraints on the absolute mass of the electron neutrino, \mnue. In this paper we investigate how this information on \mnue will affect our constraints on cosmological parameters. We consider two scenarios; one where \mnue=0 (i.e., no detection by KATRIN), and one where \mnue=0.3eV. We find that the constraints on \mnue from KATRIN will affect estimates of some important cosmological parameters significantly. For example, the significance of $n_s<1$ and the inferred value of $\Omega_\Lambda$ depend on the results from the KATRIN experiment.Comment: 13 page

A Census of Star-Forming Galaxies in the z~9-10 Universe based on HST+Spitzer Observations Over 19 CLASH clusters: Three Candidate z~9-10 Galaxies and Improved Constraints on the Star Formation Rate Density at z~9

We utilise a two-color Lyman-Break selection criterion to search for z~9-10 galaxies over the first 19 clusters in the CLASH program. A systematic search yields three z~9-10 candidates. While we have already reported the most robust of these candidates, MACS1149-JD, two additional z~9 candidates are also found and have H_{160}-band magnitudes of ~26.2-26.9. A careful assessment of various sources of contamination suggests <~1 contaminants for our z~9-10 selection. To determine the implications of these search results for the LF and SFR density at z~9, we introduce a new differential approach to deriving these quantities in lensing fields. Our procedure is to derive the evolution by comparing the number of z~9-10 galaxy candidates found in CLASH with the number of galaxies in a slightly lower redshift sample (after correcting for the differences in selection volumes), here taken to be z~8. This procedure takes advantage of the fact that the relative volumes available for the z~8 and z~9-10 selections behind lensing clusters are not greatly dependent on the details of the lensing models. We find that the normalization of the UV LF at z~9 is just 0.28_{-0.20}^{+0.39}\times that at z~8, ~1.4_{-0.8}^{+3.0}x lower than extrapolating z~4-8 LF results. While consistent with the evolution in the UV LF seen at z~4-8, these results marginally favor a more rapid evolution at z>8. Compared to similar evolutionary findings from the HUDF, our result is less insensitive to large-scale structure uncertainties, given our many independent sightlines on the high-redshift universe.Comment: 22 pages, 11 figures, 5 tables, accepted for publication in the Astrophysical Journal, updated to include the much deeper Spitzer/IRAC observations over our three z~9-10 candidate

CLASH: A Census of Magnified Star-Forming Galaxies at z ~ 6-8

We utilize 16 band Hubble Space Telescope (HST) observations of 18 lensing clusters obtained as part of the Cluster Lensing And Supernova survey with Hubble (CLASH) Multi-Cycle Treasury program to search for $z\sim6-8$ galaxies. We report the discovery of 204, 45, and 13 Lyman-break galaxy candidates at $z\sim6$, $z\sim7$, and $z\sim8$, respectively, identified from purely photometric redshift selections. This large sample, representing nearly an order of magnitude increase in the number of magnified star-forming galaxies at $z\sim 6-8$ presented to date, is unique in that we have observations in four WFC3/UVIS UV, seven ACS/WFC optical, and all five WFC3/IR broadband filters, which enable very accurate photometric redshift selections. We construct detailed lensing models for 17 of the 18 clusters to estimate object magnifications and to identify two new multiply lensed $z \gtrsim 6$ candidates. The median magnifications over the 17 clusters are 4, 4, and 5 for the $z\sim6$, $z\sim7$, and $z\sim8$ samples, respectively, over an average area of 4.5 arcmin$^2$ per cluster. We compare our observed number counts with expectations based on convolving "blank" field UV luminosity functions through our cluster lens models and find rough agreement down to $\sim27$ mag, where we begin to suffer significant incompleteness. In all three redshift bins, we find a higher number density at brighter observed magnitudes than the field predictions, empirically demonstrating for the first time the enhanced efficiency of lensing clusters over field surveys. Our number counts also are in general agreement with the lensed expectations from the cluster models, especially at $z\sim6$, where we have the best statistics.Comment: Accepted for publication in the Astrophysical Journal, 25 pages, 13 figures, 7 table

What it takes to measure a fundamental difference between dark matter and baryons: the halo velocity anisotropy

Numerous ongoing experiments aim at detecting WIMP dark matter particles from the galactic halo directly through WIMP-nucleon interactions. Once such a detection is established a confirmation of the galactic origin of the signal is needed. This requires a direction-sensitive detector. We show that such a detector can measure the velocity anisotropy beta of the galactic halo. Cosmological N-body simulations predict the dark matter anisotropy to be nonzero, beta~0.2. Baryonic matter has beta=0 and therefore a detection of a nonzero beta would be strong proof of the fundamental difference between dark and baryonic matter. We estimate the sensitivity for various detector configurations using Monte Carlo methods and we show that the strongest signal is found in the relatively few high recoil energy events. Measuring beta to the precision of ~0.03 will require detecting more than 10^4 WIMP events with nuclear recoil energies greater than 100 keV for a WIMP mass of 100 GeV and a 32S target. This number corresponds to ~10^6 events at all energies. We discuss variations with respect to input parameters and we show that our method is robust to the presence of backgrounds and discuss the possible improved sensitivity for an energy-sensitive detector.Comment: 15 pages, 8 figures, accepted by JCAP. Matches accepted versio

CLASH: z ~ 6 young galaxy candidate quintuply lensed by the frontier field cluster RXC J2248.7-4431

We present a quintuply lensed z ~ 6 candidate discovered in the field of the galaxy cluster RXC J2248.7-4431 (z ~ 0.348) targeted within the Cluster Lensing and Supernova survey with Hubble (CLASH) and selected in the deep HST Frontier Fields survey. Thanks to the CLASH 16-band HST imaging, we identify the quintuply lensed z ~ 6 candidate as an optical dropout in the inner region of the cluster, the brightest image having magAB=24.81+-0.02 in the f105w filter. We perform a detailed photometric analysis to verify its high-z and lensed nature. We get as photometric redshift z_phot ~ 5.9, and given the extended nature and NIR colours of the lensed images, we rule out low-z early type and galactic star contaminants. We perform a strong lensing analysis of the cluster, using 13 families of multiple lensed images identified in the HST images. Our final best model predicts the high-z quintuply lensed system with a position accuracy of 0.8''. The magnifications of the five images are between 2.2 and 8.3, which leads to a delensed UV luminosity of L_1600 ~ 0.5L*_1600 at z=6. We also estimate the UV slope from the observed NIR colours, finding a steep beta=-2.89+-0.38. We use singular and composite stellar population SEDs to fit the photometry of the hiz candidate, and we conclude that it is a young (age <300 Myr) galaxy with mass of M ~ 10^8Msol, subsolar metallicity (Z<0.2Zsol) and low dust content (AV ~ 0.2-0.4).Comment: 21 pages, 13 figures, 6 tables, submitted to MNRAS on 11 Aug 2013, accepted on 23 Nov 201

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent G1/S cell cycle transition through cytoplasm localization. The gain of cytosolic DEDD enhances cyclin D1 expression by interacting with heat shock 71 kDa protein 8 (HSC70). Concurrently, DEDD interacts with Rb family proteins and promotes their proteasome-mediated degradation. DEDD overexpression renders TNBCs vulnerable to cell cycle inhibition. Patients with TNBC have been excluded from CDK 4/6 inhibitor clinical trials due to the perceived high frequency of Rb-loss in TNBCs. Interestingly, our study demonstrated that, irrespective of Rb status, TNBCs with DEDD overexpression exhibit a DEDD-dependent vulnerability to combinatorial treatment with CDK4/6 inhibitor and EGFR inhibitor in vitro and in vivo. Thus, our study provided a rationale for the clinical application of CDK4/6 inhibitor combinatorial regimens for patients with TNBC