Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology

Background: As increasing numbers of dengue vaccines and therapeutics are in clinical development, standardized consensus clinical endpoint definitions are urgently needed to assess the efficacy of different interventions with respect to disease severity. We aimed to convene dengue experts representing various sectors and dengue endemic areas to review the literature and propose clinical endpoint definitions for moderate and severe disease based on the framework provided by the WHO 2009 classification. Methods: The endpoints were first proposed and discussed in a structured expert consultation. After that, the Delphi method was carried out to assess the usefulness, validity and feasibility of the standardized clinical disease endpoints for interventional dengue research. Results: Most respondents (> 80%) agreed there is a need for both standardized clinical endpoints and operationalization of severe endpoints. Most respondents (67%) felt there is utility for moderate severity endpoints, but cited challenges in their development. Hospitalization as a moderate endpoint of disease severity or measure of public health impact was deemed to be useful by only 47% of respondents, but 89% felt it could bring about supplemental information if carefully contextualized according to data collection setting. Over half of the respondents favored alignment of the standard endpoints with the WHO guidelines (58%), but cautioned that the endpoints could have ramifications for public health practice. In terms of data granularity of the endpoints, there was a slight preference for a categorical vs numeric system (e.g. 1–10) (47% vs 34%), and 74% of respondents suggested validating the endpoints using large prospective data sets. Conclusion: The structured consensus-building process was successful taking into account the history of the debate around potential endpoints for severe dengue. There is clear support for the development of standardized endpoints for interventional clinical research and the need for subsequent validation with prospective data sets. Challenges include the complexity of developing moderate disease research endpoints for dengue

Out-of-hours emergency dental hospital service: Creation and preliminary results

International audienc

Out-of-hours emergency dental hospital service: Creation and preliminary results

International audienc

Réduire les émissions GES de nos déplacements professionnels : Une Démarche collaborative à l'IRISA/Inria

Ce rapport expose les travaux menés par le groupe de travail «~missions~» de l'IRISA et du centre Inria de l'Université de Rennes sur l'impact environnemental de nos activités de recherche, et en particulier des émissions de Gaz à Effet de Serre (GES) dues aux trajets en avions. Le groupe de travail, composé d'une quinzaine de membres des différentes tutelles, a abordé ces questions entre septembre 2022 et décembre 2023. Après une phase de réflexion préliminaire visant à dresser une cartographie des pratiques de voyage ainsi que des actions similaires menées en dehors du centre de recherche, le groupe a mis en place une phase d'action participative en trois actes~: I) réalisation du bilan de GES du centre pour l'année 2022; II) organisation d'un atelier participatif visant à questionner nos pratiques de voyages et à construire des mesures de réduction; III) consultation démocratique via une assemblée générale et un sondage en ligne, permettant d'estimer l'acceptabilité de ces différentes mesures de réduction et de les valider