Planning TOD with Land Use and Transport Integration: a Review

Transit Oriented Development (TOD) implementation in urban development is globally adopted by many countries in the world in a rapid manner. However, the city and regional acute problems is still propagating. An in-depth study to examine this problem is required. Thus, this paper review various study related to the integration of land use and transport with TOD. The subject of the paper will be described as follow: Method, criteria and indicators of TOD\u27S research, Reviewing the strategic plan and the public transport plan in the worldwide, and Cross-continent comparison of integration planning. In conclusion, practice and integration of TOD through land use and transportation is an alternative solution in acquiring the objective of the master plan and to solve urban issues such as urban congestion, reduce travel time, and car dependency

Re-Assessing TOD Index in Jakarta Metropolitan Region (JMR)

Transit Oriented Development (TOD) is believed to be able to overcome the issues of urban transport. However, in practice, the current TOD in Jakarta  Metropolitan Region (JMR) is still a deficiency in accommodating the needs of transportation movement and not in facilitating services in terms of TOD function. The objective of this paper was to re-assess the service quality of actual TOD in 54 commuter railway stations. The paper performed criteria-indicators and measured a composite TOD index by using Analytical Hierarchy Process (AHP)-multicriteria model, statistics test, and Geographical Information System (GIS) application. TOD index was found that urban areas have a high TOD index. On the other hand, the suburban areas have a low TOD-index. The statistical test showed that there was a strong correlation between different criteria. This paper concluded that most of the stations which were located in the suburban area had a low index thus need improvement. Consequently, the station areas needed to have a policy relevance. &nbsp

Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads

The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary development. It is well established that germ cells are not required for the establishment or maintenance of Sertoli cells or testis cords in the male gonad. However, in the agametic ovary, follicles do not form suggesting that germ cells may influence granulosa cell development. Prior investigations of ovaries in which pre-meiotic germ cells were ablated during fetal life reported no histological changes during stages prior to birth. However, whether granulosa cells underwent normal molecular differentiation was not investigated. In cases where germ cell loss occurred secondary to other mutations, transdifferentiation of granulosa cells towards a Sertoli cell fate was observed, raising questions about whether germ cells play an active role in establishing or maintaining the fate of granulosa cells. We developed a group of molecular markers associated with ovarian development, and show here that the loss of pre-meiotic germ cells does not disrupt the somatic ovarian differentiation program during fetal life, or cause transdifferentiation as defined by expression of Sertoli markers. Since we do not find defects in the ovarian somatic program, the subsequent failure to form follicles at perinatal stages is likely attributable to the absence of germ cells rather than to defects in the somatic cells.Stem Cell and Regenerative Biolog

A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development

Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling difficult and potentially hindering optimal treatment. Here, we describe the analysis of a 46,XY DSD patient that presented at birth with ambiguous genitalia. Histological analysis of the surgically removed gonads showed bilateral undifferentiated gonadal tissue and immature testis, both containing malignant germ cells. We screened genomic DNA from this patient for deletions and duplications using an Illumina whole-genome SNP microarray. This analysis revealed a heterozygous deletion within the WWOX gene on chromosome 16, removing exons 6-8. Analysis of parental DNA showed that the deletion was inherited from the mother. cDNA analysis confirmed that the deletion maintained the reading frame, with exon 5 being spliced directly onto exon 9. This deletion is the first description of a germline rearrangement affecting the coding sequence of WWOX in humans. Previously described Wwox knockout mouse models showed gonadal abnormalities, supporting a role for WWOX in human gonad development

Unmasking a role for sex chromosomes in gene silencing

Several sexually dimorphic phenotypes correlate with sex-chromosome dosage rather than with phenotypic sex. New research suggests that sex chromosome dimorphism helps to regulate gene silencing

How can we enhance sexual health outcomes in men who have sex with men in Lebanon?

In Lebanese men who have sex with men (MSM), the prevalence of HIV is 12% and the prevalence of having at least one symptom of a sexually transmitted infection (STI) is 34.9%.1 Low HIV testing rates, unprotected unprotected sexual intercourse, alcohol and substance use contribute to this epidemic.2 Here we present data on the prevalence of STIs in a sample of MSM attending a sexual health clinic in order to identify the correlates of risk-taking behaviour, and of testing behaviour in this population. Addressing these questions is crucial for reducing the incidence of HIV/STIs and, thus, for enhancing sexual health outcomes in this high-risk population in Lebanon

炭水化物水酸基の相対的反応性について (そのII) : ペントースの選択的エステル化反応を中心に

Landfill site of Tangier City is non-engineered low lying open dump. It has neither bottom liner nor leachate collection and treatment system. Therefore, all the leachate generated finds its paths into the surrounding environment Leachate samples of landfill site were collected and analyzed to estimate its pollution potential. The analyzed samples contained a high concentration of organic and inorganic compounds, beyond the permissible limits

Implementation of the Integrated TOD Spatial Model for Jakarta Metropolitan Region

Jakarta Metropolitan Region (JMR) is the biggest megacity urban areas in Indonesia. However,theexistingpublictransportfacilitiesarenotadequatelyfulfillingthedemand ofitsinhabitant.Therefore,itisimportantforovercomingthoseissueswithshedlighton the integration of spatial and transportation by applying Transit Oriented Development (TOD) model. The method of this paper using the spatial and transportation approach by differentiates TOD each railway stations based on the typology. The results were that the TOD spatial model is focusing on solving public transport issues related to urban planning. Therefore, certain policy from stakeholders for this region greatly encourages transport planning in a more sustainable manner

Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline

The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy