10 research outputs found
Monitoring Enzymatic RNA G-Quadruplex Unwinding Activities by Nuclease Sensitivity and Reverse Transcription Stop Assays
No full textStability is not everything the case of the cyclization of the thrombin binding aptamer
No full textAiming at novel approaches to obtain improved aptamers, we developed a cyclic TBA analogue (cycTBA) by exploiting a Cu(I)-assisted azide-alkyne cycloaddition. Its markedly increased serum resistance and exceptional thermal stability of its G-quadruplex vs. TBA were associated to halved thrombin inhibition, suggesting that some flexibility in TBA structure is necessary for protein recognition
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
No full textInvestigation of higher-order RNA G-quadruplex structures in vitro and in living cells by 19F NMR spectroscopy
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