Coopetitive business models in future mobile broadband with licensed shared access (LSA)

6siopenSpectrum scarcity forces mobile network operators (MNOs) providing mobile broadband services to develop new business models that address spectrum sharing. It engages MNOs into coopetitive relationship with incumbents. Licensed Shared Access (LSA) concept complements traditional licensing and helps MNOs to access new spectrum bands on a shared basis. This paper discusses spectrum sharing with LSA from business perspective. It describes how coopetition and business model are linked conceptually, and identifies the influence of coopetition on future business models in LSA. We develop business models for dominant and challenger MNOs in traditional licensing and future with LSA. The results indicate that coopetition and business model concepts are linked via value co-creation and value co-capture. LSA offers different business opportunities to dominant and challenger MNOs. Offering, value proposition, customer segments and differentiation in business models become critical in mobile broadband.openP. Ahokangas; M. Matinmikko; I. Atkova; L.F. Minervini; S. Yrjölä; M. MustonenP., Ahokangas; M., Matinmikko; I., Atkova; Minervini, LEO FULVIO; S., Yrjölä; M., Mustone

Configurable DC current leads, with Peltier elements

There is interest in decreasing the thermal load to the cryogenic environment from the current leads. The cryogenic load is challenging both at the design current, as well as at part load operation, when the current is reduced or zero. In this paper we explore the combination of a Peltier elements and a novel concept of configurable current lead. The use of Peltier element reduces the cryogenic load by about 25%. The configurable concept is based on the use of multiple heat exchangers that allows the optimization of current leads when operating at various currents. When used together, Peltier/configurable current lead allows the reduction of the cryogenic load by a factor of 4 in low current/idle conditions. We also explore the transient operation of the current leads, as well as overload capacity.

Imatinib-mesylate for all patients with hypereosinophilic syndrome?

Some recent papers have focused on the activity of imatinib-mesylate, a selective inhibitor of tyrosine kinase, in idiopathic hypereosinophilic syndrome (HES) [1], [2], [3] and [4]. In this setting, a possible therapeutic target was identified by Cools et al. [2], who described the fusion tyrosine-kinase gene FIP1L1/PDGFRA as the result of an interstitial deletion within chromosome 4 in nine out of sixteen (56%) patients affected by HES. Of interest, although in this study the response to imatinib was strictly correlated with the presence of FIP1L1/PDGFRA rearrangement (all patients with such a molecular lesion treated with imatinib responded), only five out of nine responding patients evidenced the abnormal transcript [2]. Among the possible alternative mechanisms for the activation of the PDGFRA tyrosine-kinase domain, these authors suggested there may be a different fusion gene

A survey of the main technology, biochemical and microbiological features influencing the concentration of biogenic amines of twenty Apulian and Sicilian (Southern Italy) cheeses

Abstract Twenty Apulian and Sicilian cheeses were analysed for their concentrations of eight biogenic amines (BAs), free amino acids, pH, water activity, and subjected to microbiological characterisation. In addition, lactic acid bacteria isolated from cheeses were assayed for their capacity to generate BAs. Principal component analysis was performed to find the effect of different parameters on the distribution of the cheeses. Although short-ripened (≤30 d) cheeses did not show significant BA concentrations, the only BA showing high positive correlation with time of ripening was histamine. Concentration of histidine and, especially, percentage of histidine-decarboxylase bacteria presumably affected histamine concentration. High pH values were negatively correlated to the concentration of tyramine, putrescine, and cadaverine. Fifty percent of the cheeses contained at least one BA at potentially toxic concentrations. Unambiguous and ever-valid relations among parameters and BAs are difficult to determine, because BAs are the result of combined and varied factors

Minilaparoscopic Versus Open Pyeloplasty in Children Less Than 1 Year

Purpose: The aim of this study is to compare minilaparoscopic (MLS) and open pyeloplasty (OP) in children <1 year in terms of intra- and perioperative outcomes and esthetic results. Materials and Methods: Patients <1 year of age, with prenatal hydronephrosis, who underwent Anderson-Hynes pyeloplasty for monolateral ureteropelvic junction obstruction (UPJO) at our center from January 2016 to August 2017 were enrolled in the study. Outcomes evaluated were as follows: operative time, length of hospital stay, and postoperative pain anterior-posterior pelvic diameter (APD) reduction. The Vancouver Scar Scale (VSS) was utilized to evaluate esthetic results. Mean follow-up was 26.5 months. Results: Eighteen patients (11M, 7F) of mean age 8.1 months (range 4-12) and mean weight 8.5 kg (range 7-10) underwent Anderson-Hynes pyeloplasty in the study period. Nine of eighteen underwent OP, and 9/18 underwent MLS. Mean operative time was 167 minutes for MLS versus 153 minutes for OP (P = .14). Mean hospital stay was 3.9 days for MLS versus 5.3 days for OP (P = .11). Mean APD reduction was 13.6 mm for MLS and 16.5 mm for OP procedures (P = .63). Mean VSS score was 1.3 for VLS versus 3.4 for OP (P = .04). Conclusions: MLS pyeloplasty is feasible and safe, and reported equivalent results as open procedure for management of UPJO also in toddlers and infants. We found that the only significant difference between the two approaches in children <1 year was represented by the esthetic outcome in the short follow-up period