REALTA’ / WIRKLICHKEIT WIRKLICHKEIT / REALITY

Terzo volume della collana I cataloghi della Galleria del Progetto Serie rossa | Red Series Un progetto in mostra | A Project on Display. Catalogo della mostra MODERSOHN & FREIESLEBEN REALTA’ / WIRKLICHKEIT WIRKLICHKEIT / REALITY tenutasi al Politecnico di Milano, Galleria del Progetto, il 16 | 05 – 10 | 06 | 2022

Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model

Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ∼70% in the established treatment system. Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14