Clustering and collisions of heavy particles in random smooth flows

Finite-size impurities suspended in incompressible flows distribute inhomogeneously, leading to a drastic enhancement of collisions. A description of the dynamics in the full position-velocity phase space is essential to understand the underlying mechanisms, especially for polydisperse suspensions. These issues are here studied for particles much heavier than the fluid by means of a Lagrangian approach. It is shown that inertia enhances collision rates through two effects: correlation among particle positions induced by the carrier flow and uncorrelation between velocities due to their finite size. A phenomenological model yields an estimate of collision rates for particle pairs with different sizes. This approach is supported by numerical simulations in random flows.Comment: 12 pages, 9 Figures (revTeX 4) final published versio

Large-scale effects on meso-scale modeling for scalar transport

The transport of scalar quantities passively advected by velocity fields with a small-scale component can be modeled at meso-scale level by means of an effective drift and an effective diffusivity, which can be determined by means of multiple-scale techniques. We show that the presence of a weak large-scale flow induces interesting effects on the meso-scale scalar transport. In particular, it gives rise to non-isotropic and non-homogeneous corrections to the meso-scale drift and diffusivity. We discuss an approximation that allows us to retain the second-order effects caused by the large-scale flow. This provides a rather accurate meso-scale modeling for both asymptotic and pre-asymptotic scalar transport properties. Numerical simulations in model flows are used to illustrate the importance of such large-scale effects.Comment: 19 pages, 8 figure

The pseudo GTPase CENP-M drives human kinetochore assembly

Basilico, Federica et al.Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division. The configuration and function of the kinetochore–centromere interface is poorly understood. We report that a protein at this interface, CENP-M, is structurally and evolutionarily related to small GTPases but is incapable of GTP-binding and conformational switching. We show that CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches. A point mutant affecting the CENP-M/CENP-I interaction hampers kinetochore assembly and chromosome alignment and prevents kinetochore recruitment of the CENP-T/W complex, questioning a role of CENP-T/W as founder of an independent axis of kinetochore assembly. Our studies identify a single pathway having CENP-C as founder, and CENP-H/I/K/M and CENP-T/W as CENP-C-dependent followers.AM acknowledges funding by the European Union's 7th Framework Program ERC agreement KINCON and the Integrated Project MitoSys. FH is supported by the Bavarian Research Center of Molecular Biosystems and by a LMU excellent junior grant.Peer reviewe

Inertial particles driven by a telegraph noise

We present a model for the Lagrangian dynamics of inertial particles in a compressible flow, where fluid velocity gradients are modelled by a telegraph noise. The model allows for an analytic investigation of the role of time correlation of the flow in the aggregation-disorder transition of inertial particle. The dependence on Stokes and Kubo numbers of the Lyapunov exponent of particle trajectories reveals the presence of a region in parameter space (St, Ku) where the leading Lyapunov exponent changes sign, thus signaling the transition. The asymptotics of short and long-correlated flows are discussed, as well as the fluid-tracer limit.Comment: 8 pages, 6 figure

Statistics of mixing in three-dimensional Rayleigh--Taylor turbulence at low Atwood number and Prandtl number one

Three-dimensional miscible Rayleigh--Taylor (RT) turbulence at small Atwood number and at Prandtl number one is investigated by means of high resolution direct numerical simulations of the Boussinesq equations. RT turbulence is a paradigmatic time-dependent turbulent system in which the integral scale grows in time following the evolution of the mixing region. In order to fully characterize the statistical properties of the flow, both temporal and spatial behavior of relevant statistical indicators have been analyzed. Scaling of both global quantities ({\it e.g.}, Rayleigh, Nusselt and Reynolds numbers) and scale dependent observables built in terms of velocity and temperature fluctuations are considered. We extend the mean-field analysis for velocity and temperature fluctuations to take into account intermittency, both in time and space domains. We show that the resulting scaling exponents are compatible with those of classical Navier--Stokes turbulence advecting a passive scalar at comparable Reynolds number. Our results support the scenario of universality of turbulence with respect to both the injection mechanism and the geometry of the flow

Lyapunov exponents of heavy particles in turbulence

Lyapunov exponents of heavy particles and tracers advected by homogeneous and isotropic turbulent flows are investigated by means of direct numerical simulations. For large values of the Stokes number, the main effect of inertia is to reduce the chaoticity with respect to fluid tracers. Conversely, for small inertia, a counter-intuitive increase of the first Lyapunov exponent is observed. The flow intermittency is found to induce a Reynolds number dependency for the statistics of the finite time Lyapunov exponents of tracers. Such intermittency effects are found to persist at increasing inertia.Comment: 4 pages, 4 figure

A foot in both camps: Redressing the balance between the \u2018pure\u2019 and applied branches of translation studies

The aim of this article is to argue for an approach to translation research integrating/bridging the divide between the descriptive, theoretical and applied branches of Translation Studies (TS). Based on a perspective of translation as cross-cultural communication centred on language and as a professional activity where the translator makes decisions, the branch of Applied Translation Studies (ATS) is seen not just as an \u201cextension\u201d of the \u201cpure\u201d branches of TS (Theory and Description), or one where theoretical statements based on the results of descriptive studies are transmitted in a unidirectional way (Toury 1995: 17-19). Rather, the applied strand of TS covering translation teaching and practice, translation quality assessment, the development of translation aids etc. is effectively incorporated in the disciplinary core of TS, providing a site for testing theoretical statements, identifying problems and providing explanations to be fed into the theory

Acceleration statistics of heavy particles in turbulence

We present the results of direct numerical simulations of heavy particle transport in homogeneous, isotropic, fully developed turbulence, up to resolution $512^3$ ($R_\lambda\approx 185$). Following the trajectories of up to 120 million particles with Stokes numbers, $St$, in the range from 0.16 to 3.5 we are able to characterize in full detail the statistics of particle acceleration. We show that: ({\it i}) The root-mean-squared acceleration $a_{\rm rms}$ sharply falls off from the fluid tracer value already at quite small Stokes numbers; ({\it ii}) At a given $St$ the normalised acceleration $a_{\rm rms}/(\epsilon^3/\nu)^{1/4}$ increases with $R_\lambda$ consistently with the trend observed for fluid tracers; ({\it iii}) The tails of the probability density function of the normalised acceleration $a/a_{\rm rms}$ decrease with $St$. Two concurrent mechanisms lead to the above results: preferential concentration of particles, very effective at small $St$, and filtering induced by the particle response time, that takes over at larger $St$.Comment: 10 pages, 3 figs, 2 tables. A section with new results has been added. Revised version accepted for pubblication on Journal of Fluid Mechanic

Intermittency in two-dimensional Ekman-Navier-Stokes turbulence

We study the statistics of the vorticity field in two-dimensional Navier-Stokes turbulence with a linear Ekman friction. We show that the small-scale vorticity fluctuations are intermittent, as conjectured by Nam et al. [Phys. Rev. Lett. vol.84 (2000) 5134]. The small-scale statistics of vorticity fluctuations coincides with the one of a passive scalar with finite lifetime transported by the velocity field itself.Comment: 4 pages, 7 figure

Power-Law Distributions in a Two-sided Market and Net Neutrality

"Net neutrality" often refers to the policy dictating that an Internet service provider (ISP) cannot charge content providers (CPs) for delivering their content to consumers. Many past quantitative models designed to determine whether net neutrality is a good idea have been rather equivocal in their conclusions. Here we propose a very simple two-sided market model, in which the types of the consumers and the CPs are {\em power-law distributed} --- a kind of distribution known to often arise precisely in connection with Internet-related phenomena. We derive mostly analytical, closed-form results for several regimes: (a) Net neutrality, (b) social optimum, (c) maximum revenue by the ISP, or (d) maximum ISP revenue under quality differentiation. One unexpected conclusion is that (a) and (b) will differ significantly, unless average CP productivity is very high