Structure of ethyl 1-cyanomethyl-5-methoxy-3-phenylindole-2-carboxylate

C20HI8N203, M r = 334.38, orthorhombic, Pbca, a = 7.179 (3), b = 33.014 (3), c = 14.847 (1) A, V = 3518.85/~3, Z = 8, Dx = 1.262, D m = by 53.1 (3) °. The C--C~N chain is linear and makes a dihedral angle of 77.9 (3) ° with the mean plane of the indole ring. The mean plane of the carboxyl group makes a dihedral angle of 25.4 (3) ° with the indole moiety

Sequence and phylogenetic analysis of viper venom serine proteases

Snakebites are a major neglected tropical disease responsible for as many as 95000 deaths every year worldwide. Viper venom serine proteases disrupt haemostasis of prey and victims by affecting various stages of the blood coagulation system. A better understanding of their sequence, structure, function and phylogenetic relationships will improve the knowledge on the pathological conditions and aid in the development of novel therapeutics for treating snakebites. A large dataset for all available viper venom serine proteases was developed and analysed to study various features of these enzymes. Despite the large number of venom serine protease sequences available, only a small proportion of these have been functionally characterised. Although, they share some of the common features such as a C-terminal extension, GWG motif and disulphide linkages, they vary widely between each other in features such as isoelectric points, potential N-glycosylation sites and functional characteristics. Some of the serine proteases contain substitutions for one or more of the critical residues in catalytic triad or primary specificity pockets. Phylogenetic analysis clustered all the sequences in three major groups. The sequences with substitutions in catalytic triad or specificity pocket clustered together in separate groups. Our study provides the most complete information on viper venom serine proteases to date and improves the current knowledge on the sequence, structure, function and phylogenetic relationships of these enzymes. This collective analysis of venom serine proteases will help in understanding the complexity of envenomation and potential therapeutic avenues

Ethyl 3-oxo-2-[(4-sulfamoylphen­yl)hydra­zono]butyrate

In the title compound, C12H15N3O5S, an intra­molecular N—H⋯O hydrogen bond between the hydrazine unit and one of the carbonyl groups may influence the mol­ecular conformation. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds, including one which is bifurcated, link the mol­ecules into a two-dimensional network

Maternal and perinatal outcome in abruption placenta in tertiary care center: a record based case series study

Background: Abruptio placenta is premature separation of the normally implanted placenta before delivery. It is one of the leading causes of maternal morbidity and neonatal morbidity and mortality, more so because of the difficulty to predict the acute event. It occurs in approximately one in 80 deliveries and remains a significant cause of perinatal mortality and morbidity. Objective of the study was to study maternal and perinatal outcome in cases of abruption. Methods: 42 cases of pregnant women who presented with abruption placenta to HSK hospital and Research Centre, S. Nijalingappa Medical College, a tertiary care centre at Bagalkot, from January 2022 to December 2022. Maternal and perinatal characteristics were retrieved from the case papers. Results: Among 42 cases of abruption 70% delivered vaginally and 30% underwent caesarean section. 84% had preterm delivery. 66% were still born. 21% were case of severe anaemia and required blood transfusion. 1 had maternal mortality. Conclusions: The availability of advanced emergency obstetric care across greater number of referral hospitals has been responsible for decreasing the morbidity and mortality associated with many obstetric conditions. However, the challenge with abruptio placenta is the difficulty of predicting this condition, and hence appropriate management. As of now, early referral to tertiary care centres, better availability of blood and blood products and early interventions have the potential to limit adverse maternal and perinatal outcomes. Research regarding predictors of placental abruption can help in improving maternal and perinatal outcome.

Rhodium(I) complexes of α-keto-stabilised 1,2-bis(diphenylphosphino)alkane mono ylides

Rhodium(I) complexes of the hybrid ylide-phosphine ligands, Ph2P(CH2) n PPh2(CHC(O)C6H5) (n = 1: dppm-yl, or 2: dppe-yl) have been synthesised from [Rh(μ-C1)(COD)]2 (COD = 1,5-cyclooctadiene) and characterized by NMR spectroscopic and X-ray structural methods. The dppe-yl behaves as an ambidentate ligand; it functions as a monodentate P-donor ligand with a dangling ylidic carbon in the neutral chloro complex, [(COD)Rh(Cl)(dppe-yl)] (1), whereas replacement of the chloride by a non-coordinating counter anion results in the formation of the complexes, [(COD)Rh(L-L')]+ (L-L' = dppe-yl (2) or dppm-yl (3)) respectively in which the ligands are bonded to the metal via the phosphorus and the ylidic carbon atoms. The 1,5-cyclooctadiene (COD), present in the Rh(I) precursor, remains intact in the products. The structures of 1,2 and3 have been confirmed by X-ray crystallography

Methyl 2,2-bis­(2,4-dinitro­phen­yl)ethano­ate

In the title compound, C15H10N4O10, the dihedral angle between the aromatic rings is 89.05 (16)°. One O atom of one of the nitro groups is disordered over two sites in a 0.70:0.30 ratio. In the crystal, the mol­ecules are linked by weak C—H⋯O inter­actions

4-[2-(1-Acetyl-2-oxopropyl­idene)­hydrazino]-N-(pyrimidin-2-yl)benzene­sulfonamide

In the title compound, C15H15N5O4S, the dihedral angle between the pyrimidine and benzene rings is 84.56 (2)°. Intra­molecular hydrazine–carbonyl N—H⋯O and inter­molecular sulfonamide–pyridimine N—H⋯N hydrogen bonds stabilize the mol­ecular and crystal structures, respectively

Analysis of Wheat Export Performance in India

Wheat is a plant which is valued highly for its kernel as an edible part and an important source of carbohydrates. India ranks second position in wheat production in the world with a contribution of roughly 13.53 per cent to global wheat output (Naga Latha et. al., 2022). The study analyses the export performance of wheat and examines the trends in the growth performance of wheat in terms of area, production and productivity, export quantity and export value during 1973-2022 which is a period of 50 years. The analysis reveals that the highest compound growth rate in terms of area was 1.16 per cent, production was 4.49 per cent and productivity was 3.29 per cent respectively. The results of the study on the compound growth rates during the study periods have shown positive and increasing value which indicates high potential for the export of wheat from India. In the analysis of instability, there exists a high positive correlation between the export quantity and value of export in the overall period. Wheat area, production and productivity exhibit higher variability and instability in the overall period. Period II shows lower variability and instability, indicating increased stability. Period I exhibits moderate variability and instability. The overall period has the highest instability, suggesting unpredictable production. Instability indices show high instability at 126.97 per cent in Period I and 138.18 per cent overall, while Period II exhibits moderate instability at 101.94 per cent. Market volatility, trade policies, economic fluctuations, weather patterns and production variability contribute to these fluctuations. As of trend analysis, there is a positive and significant increase. The NPC value of wheat during the overall period was 0.051, it indicates that the commodity is not protected. NPC<1 indicates that the commodity is exportable and possesses export competitiveness and hence the hypothesis i.e. Indian wheat has better competitiveness in the International market