36 research outputs found
CIX - A Detector for Spectral Enhanced X-ray Imaging by Simultaneous Counting and Integrating
A hybrid pixel detector based on the concept of simultaneous charge
integration and photon counting will be presented. The second generation of a
counting and integrating X-ray prototype CMOS chip (CIX) has been operated with
different direct converting sensor materials (CdZnTe and CdTe) bump bonded to
its 8x8 pixel matrix. Photon counting devices give excellent results for low to
medium X-ray fluxes but saturate at high rates while charge integration allows
the detection of very high fluxes but is limited at low rates by the finite
signal to noise ratio. The combination of both signal processing concepts
therefore extends the resolvable dynamic range of the X-ray detector. In
addition, for a large region of the dynamic range, where counter and integrator
operate simultaneously, the mean energy of the detected X-ray spectrum can be
calculated. This spectral information can be used to enhance the contrast of
the X-ray image. The advantages of the counting and integrating signal
processing concept and the performance of the imaging system will be reviewed.
The properties of the system with respect to dynamic range and sensor response
will be discussed and examples of imaging with additional spectral information
will be presented.Comment: 12 pages, 14 figures, SPIE Medical Imaging Conference, San Diego,
200
Analysis of lead oxide (PbO) layers for direct conversion X-ray detection
Lead oxide (PbO) is a candidate direct conversion material for medical X-ray applications. We produced various samples and detectors with thick PbO layers. X-ray performance data such as dark current, charge generation yield and temporal behavior were evaluated on small samples. The influence of the metal contacts was studied in detail. We also covered large a-Si thin-film transistor (TFT)-plates with PbO. Imaging results from a large detector with an active area of 18 cm × 20 cm are presented. The detector has 960 × 1080 pixels with a pixel pitch of 184 ?m. The modulation transfer function at the Nyquist frequency of 2.72 linepairs/mm is 50%. Finally, a full size X-ray image is presented
Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts
Characterization of a double-sided silicon strip detector autoradiography system
The most commonly used technology currently used for autoradiography is storage phosphor screens, which has many benefits such as a large field of view but lacks particle-counting detection of the time and energy of each detected radionuclide decay. A number of alternative designs, using either solid state or scintillator detectors, have been developed to address these issues. The aim of this study is to characterize the imaging performance of one such instrument, a double-sided silicon strip detector (DSSD) system for digital autoradiography. A novel aspect of this work is that the instrument, in contrast to previous prototype systems using the same detector type, provides the ability for user accessible imaging with higher throughput. Studies were performed to compare its spatial resolution to that of storage phosphor screens and test the implementation of multiradionuclide ex vivo imaging in a mouse preclinical animal study
