Shock and statistical acceleration of energetic particles in the interplanetary medium

Definite evidence for particle acceleration in the solar wind came around a decade ago. Two likely sources are known to exist: particles may be accelerated by the turbulence resulting from the superposition of Alfven and Magnetosonic waves (Statistical Acceleration) or they may be accelerated directly at shock fronts formed by the interaction of fast and slow solar wind (CIR's) or by traveling shocks due to sporadic coronal mass ejections. Naurally both mechanisms may be operative. In this work the acceleration problem was tackled numerically using Helios 1 and 2 data to create a realistic representation of the Heliospheric plasma. Two 24 hour samples were used: one where there are only wave like fluctuations of the field (Day 90 Helios 1) and another with a shock present in it (Day 92 of Helios 2) both in 1976 during the STIP 2 interval. Transport coefficients in energy space have been calculated for particles injected in each sample and the effect of the shock studied in detail

Reduction of Coincident Photomultiplier Noise Relevant to Astroparticle Physics Experiment

In low background and low threshold particle astrophysics experiments using observation of Cherenkov or scintillation light it is common to use pairs or arrays of photomultipliers operated in coincidence. In such circumstances, for instance in dark matter and neutrino experiments, unexpected PMT noise events have been observed, probably arising from generation of light from one PMT being detected by one or more other PMTs. We describe here experimental investigation of such coincident noise events and development of new techniques to remove them using novel pulse shape discrimination procedures. When applied to data from a low background NaI detector with facing PMTs the new procedures are found to improve noise rejection by a factor of 20 over conventional techniques, with significantly reduced loss of signal events.Comment: Submitted to NIM

Assessing the association between oral hygiene and preterm birth by quantitative light-induced fluorescence

The aim of this study was to investigate the purported link between oral hygiene and preterm birth by using image analysis tools to quantify dental plaque biofilm. Volunteers (η = 91) attending an antenatal clinic were identified as those considered to be “at high risk” of preterm delivery (i.e., a previous history of idiopathic preterm delivery, case group) or those who were not considered to be at risk (control group). The women had images of their anterior teeth captured using quantitative light-induced fluorescence (QLF). These images were analysed to calculate the amount of red fluorescent plaque (ΔR%) and percentage of plaque coverage. QLF showed little difference in ΔR% between the two groups, 65.00% case versus 68.70% control, whereas there was 19.29% difference with regard to the mean plaque coverage, 25.50% case versus 20.58% control. A logistic regression model showed a significant association between plaque coverage and case/control status (Ρ = 0.031), controlling for other potential predictor variables, namely, smoking status, maternal age, and body mass index (BMI)

Short-period variability in the galactic cosmic ray intensity: High statistical resolution observations and interpretation around the time of a Forbush decrease in August 2006

On 20 August 2006 a Forbush decrease observed at Polar in the Earth's magnetosphere was also seen at the INTEGRAL spacecraft outside the magnetosphere during a very active time in the solar wind. High-resolution energetic particle data from ACE SIS, the Polar high-sensitivity telescope, and INTEGRAL's Ge detector saturation rate, which measures the galactic cosmic ray (GCR) background with a threshold of similar to 200 MeV, show similar, short-period GCR variations in and around the Forbush decrease. Focusing upon the GCR intensity within a 3-day interval from 19 August 2006 to 21 August 2006 reveals many intensity variations in the GCR on a variety of time scales and amplitudes. These intensity variations are greater than the 3 sigma error in all the data sets used. The fine structures in the GCR intensities along with the Forbush decrease are propagated outward from ACE to the Earth with very little change. The solar wind speed stays relatively constant during these periods, indicating that parcels of solar wind are transporting the GCR population outward in the heliosphere. This solar wind convection of GCR fine structure is observed for both increases and decreases in GCR intensity, and the fine structure increases and decreases are bracketed by solar wind magnetic field discontinuities associated with interplanetary coronal mass ejection (ICME) magnetosheath regions, clearly seen as discontinuous rotations of the field components at ACE and at Wind. Interestingly, the electron heat flux shows different flux tube connectivity also associated with the different regions of the ICME and magnetosheath. Gosling et al. (2004) first discussed the idea that solar energetic particle intensities commonly undergo dispersionless modulation in direct association with discontinuous changes in the solar wind electron strahl. The observations show that the intensity levels in the GCR flux may undergo a similar partitioning, possibly because of the different magnetic field regions having differing magnetic topologies

Progesterone-dependent induction of phospholipase C-related catalytically inactive protein 1 (PRIP-1) in decidualizing human endometrial stromal cells

Decidualization denotes the transformation of endometrial stromal cells into specialized decidual cells. In pregnancy, decidual cells form a protective matrix around the implanting embryo, enabling coordinated trophoblast invasion and formation of a functional placenta. Continuous progesterone (P4) signaling renders decidual cells resistant to various environmental stressors, whereas withdrawal inevitably triggers tissue breakdown and menstruation or miscarriage. Here, we show that PLCL1, coding phospholipase C (PLC)-related catalytically inactive protein 1 (PRIP-1), is highly induced in response to P4 signaling in decidualizing human endometrial stromal cells (HESCs). Knockdown experiments in undifferentiated HESCs revealed that PRIP-1 maintains basal phosphoinositide 3-kinase/Protein kinase B activity, which in turn prevents illicit nuclear translocation of the transcription factor forkhead box protein O1 and induction of the apoptotic activator BIM. By contrast, loss of this scaffold protein did not compromise survival of decidual cells. PRIP-1 knockdown did also not interfere with the responsiveness of HESCs to deciduogenic cues, although the overall expression of differentiation markers, such as PRL, IGFBP1, and WNT4, was blunted. Finally, we show that PRIP-1 in decidual cells uncouples PLC activation from intracellular Ca2+ release by attenuating inositol 1,4,5-trisphosphate signaling. In summary, PRIP-1 is a multifaceted P4-inducible scaffold protein that gates the activity of major signal transduction pathways in the endometrium. It prevents apoptosis of proliferating stromal cells and contributes to the relative autonomy of decidual cells by silencing PLC signaling downstream of Gq protein-coupled receptors

GeV Photons from Ultra High Energy Cosmic Rays accelerated in Gamma Ray Bursts

Gamma-ray bursts are produced by the dissipation of the kinetic energy of a highly relativistic fireball, via the formation of a collisionless shock. When this happens, Ultra High Energy Cosmic Rays up to 10^20 eV are produced. I show in this paper that these particles produce, via synchrotron emission as they cross the acceleration region, photons up to 300 GeV which carry away a small, ~0.01, but non-negligible fraction of the total burst energy. I show that, when the shock occurs with the interstellar medium, the optical depth to photon-photon scattering, which might cause energy degradation of the photons, is small. The burst thusly produced would be detected at Earth simultaneoulsy with the parent gamma-ray burst, although its duration may differ significantly from that of the lower energy photons. The expected fluences, ~10^{-5}-10^{-6} erg/cm^2 are well within the range of planned detectors. A new explanation for the exceptional burst GRB 940217 is discussed.Comment: Accepted for publication in The Physical Review Letters. 4 pages, RevTeX needed, no figure

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endometrial stromal cells (H-EnSCs) of women with RM discriminate less effectively between high-and low-quality human embryos and migrate more readily towards trophoblast spheroids than H-EnSCs of normally fertile women. Methodology/Principal Findings Monolayers of decidualized H-EnSCs were generated from endometrial biopsies of 6 women with RM and 6 fertile controls. Cell-free migration zones were created and the effect of the presence of a high-quality (day 5 blastocyst, n = 13), a low-quality (day 5 blastocyst with three pronuclei or underdeveloped embryo, n = 12) or AC-1M88 trophoblast cell line spheroid on H-ESC migratory activity was analyzed after 18 hours. In the absence of a spheroid or embryo, migration of H-EnSCs from fertile or RM women was similar. In the presence of a low-quality embryo in the zone, the migration of H-EnSCs of control women was inhibited compared to the basal migration in the absence of an embryo (P<0.05) and compared to the migration in the presence of high-quality embryo (p<0.01). Interestingly, the migratory response H-EnSCs of women with RM did not differ between high- and low-quality embryos. Furthermore, in the presence of a spheroid their migration was enhanced compared to the H-EnSCs of controls (p<0.001). Conclusions H-EnSCs of fertile women discriminate between high- and low-quality embryos whereas H-EnSCs of women with RM fail to do so. H-EnSCs of RM women have a higher migratory response to trophoblast spheroids. Future studies will focus on the mechanisms by which low-quality embryos inhibit the migration of H-EnSCs and how this is deregulated in women with RM

The modulation effect for supersymmetric dark matter detection with asymmetric velocity dispersion

The detection of the theoretically expected dark matter is central to particle physics cosmology. Current fashionable supersymmetric models provide a natural dark matter candidate which is the lightest supersymmetric particle (LSP). Such models combined with fairly well understood physics like the quark substructure of the nucleon and the nuclear form factor and the spin response function of the nucleus, permit the evaluation of the event rate for LSP-nucleus elastic scattering. The thus obtained event rates are, however, very low or even undetectable. So it is imperative to exploit the modulation effect, i.e. the dependence of the event rate on the earth's annual motion. In this review we study such a modulation effect in directional and undirectional experiments. We calculate both the differential and the total rates using symmetric as well as asymmetric velocity distributions. We find that in the symmetric case the modulation amplitude is small, less than 0.07. There exist, however, regions of the phase space and experimental conditions such that the effect can become larger. The inclusion of asymmetry, with a realistic enhanced velocity dispersion in the galactocentric direction, yields the bonus of an enhanced modulation effect, with an amplitude which for certain parameters can become as large as 0.46.Comment: 35 LATEX pages, 7 Tables, 8 PostScript Figures include