Ground state factorization of heterogeneous spin models in magnetic fields

The exact factorized ground state of a heterogeneous (ferrimagnetic) spin model which is composed of two spins ($\rho, \sigma$) has been presented in detail. The Hamiltonian is not necessarily translational invariant and the exchange couplings can be competing antiferromagnetic and ferromagnetic arbitrarily between different sub-lattices to build many practical models such as dimerized and tetramerized materials and ladder compounds. The condition to get a factorized ground state is investigated for non-frustrated spin models in the presence of a uniform and a staggered magnetic field. According to the lattice model structure we have categorized the spin models in two different classes and obtained their factorization conditions. The first class contains models in which their lattice structures do not provide a single uniform magnetic field to suppress the quantum correlations. Some of these models may have a factorized ground state in the presence of a uniform and a staggered magnetic field. However, in the second class there are several spin models in which their ground state could be factorized whether a staggered field is applied to the system or not. For the latter case, in the absence of a staggered field the factorizing uniform field is unique. However, the degrees of freedom for obtaining the factorization conditions are increased by adding a staggered magnetic field.Comment: 16 pages, 6 figures, 1 table, Accepted in Progress of Theoretical Physic

Factorized ground state for a general class of ferrimagnets

We have found the exact (factorized) ground state of a general class of ferrimagnets in the presence of a magnetic field which covers the frustrated, anisotropic and long range interactions for arbitrary dimensional space. In particular cases, our model represents the bond-alternating, ferromagnet-antiferromagnet and also homogeneous spin $s$ model. The factorized ground state is a product of single particle kets on a bipartite lattice composed of two different spins ($\rho, \sigma$). The spin waves analysis around the exact ground state show two branch of excitations which is the origin of two dynamics of the model. The signature of these dynamics is addressed as a peak and a broaden bump in the specific heat.Comment: 4 pages and 2 figures, some typos correcte

Optical quenching and recovery of photoconductivity in single-crystal diamond

We study the photocurrent induced by pulsed-light illumination (pulse duration is several nanoseconds) of single-crystal diamond containing nitrogen impurities. Application of additional continuous-wave light of the same wavelength quenches pulsed photocurrent. Characterization of the optically quenched photocurrent and its recovery is important for the development of diamond based electronics and sensing

Phase diagram of the XXZ ferrimagnetic spin-(1/2, 1) chain in the presence of transverse magnetic field

We investigate the phase diagram of an anisotropic ferrimagnet spin-(1/2, 1) in the presence of a non-commuting (transverse) magnetic field. We find a magnetization plateau for the isotropic case while there is no plateau for the anisotropic ferrimagnet. The magnetization plateau can appear only when the Hamiltonian has the U(1) symmetry in the presence of the magnetic field. The anisotropic model is driven by the magnetic field from the N\'{e}el phase for low fields to the spin-flop phase for intermediate fields and then to the paramagnetic phase for high fields. We find the quantum critical points and their dependence on the anisotropy of the aforementioned field-induced quantum phase transitions. The spin-flop phase corresponds to the spontaneous breaking of Z2 symmetry. We use the numerical density matrix renormalization group and analytic spin wave theory to find the phase diagram of the model. The energy gap, sublattice magnetization, and total magnetization parallel and perpendicular to the magnetic field are also calculated. The elementary excitation spectrums of the model are obtained via the spin wave theory in the three different regimes depending on the strength of the magnetic field.Comment: 14 pages, 11 eps figure

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds.

Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion in cyclic peptides has not been investigated systematically. Here we report a method for the selective, on-resin N-methylation of cyclic peptides to generate compounds with drug-like membrane permeability and oral bioavailability. The selectivity and degree of N-methylation of the cyclic peptide was dependent on backbone stereochemistry, suggesting that conformation dictates the regiochemistry of the N-methylation reaction. The permeabilities of the N-methyl variants were corroborated by computational studies on a 1,024-member virtual library of N-methyl cyclic peptides. One of the most permeable compounds, a cyclic hexapeptide (molecular mass = 755 Da) with three N-methyl groups, showed an oral bioavailability of 28% in rat

Explorations Into Continuity: An Heuristic, Artistic Inquiry into the Interplay Between Work as a Dance/Movement Therapist and Service within the Bahá’í Community

The purpose of this thesis was to explore the concept of integration between two main aspects of my life: my professional career as a dance/movement therapist on an inpatient adolescent behavioral health unit, and service guided by Bahá’í teachings in a neighborhood-based setting. Literature reviewed encompassed instances of Rudolf von Laban’s Effort elements found in the Bahá’í Writings, as well as research on the integration between the mind, body and spirit, the history of religion and mental health, and the current relationship between religion and mental health. Both artistic inquiry and heuristic methodologies were used to guide my research. Through Moustakas’s method of data analysis – immersion, incubation, illumination, explication, and creative synthesis – certain themes surfaced that shed light on my personal embodied experience of integration, and its implications both in a dance/movement therapy (DMT) and religious vein. Two major themes included the role of improvisation in integration and the shift from fragmented language and movement to bodily integration found through utilization of the Laban Movement Analysis (LMA) Body category, in place of Effort. This study informs not only my own orientation towards integration, but also provides a platform from which both dance/movement therapists and any faith-based mental health practitioners can conceptualize integration and make it a more conscious part of their work

Using a collaborative research approach to develop an interdisciplinary research agenda for the study of mobile health interventions for older adults.

Licensed under Creative Commons Attribution cc-by 2.0Background: Seniors with chronic diseases are often called on to self-manage their conditions. Mobile health (mHealth) tools may be a useful strategy to help seniors access health information at the point of decision-making, receive real-time feedback and coaching, and monitor health conditions. However, developing successful mHealth interventions for seniors presents many challenges. One of the key challenges is to ensure the scope of possible research questions includes the diverse views of seniors, experts and the stakeholder groups who support seniors as they manage chronic disease. Objective: Our primary objective was to present a case-study of a collaborative research approach to the development of an interdisciplinary research agenda. Our secondary objectives were to report on the results of a nominal group technique (NGT) approach used generate research questions and to assess the success of including non-academic researchers to enrich the scope, priority, and total number of possible research questions. Methods: We invited researchers and stakeholders to participate in a full day meeting that included rapid-style presentations by researchers, health care professionals, technology experts, patients and community groups followed by group discussions. An NGT was used to establish group consensus on the following question: In your opinion, what research needs to be done to better understand the effectiveness, usability and design of mobile health apps and devices for older adults? Results: Overall, the collaborative approach was a very successful strategy to bring together a diverse group of participants with the same end goal. The 32 participants generated 119 items in total. The top three research questions that emerged from the NGT were related to adoption, the need for high quality tools and the digital divide. Strong sub-themes included privacy and security, engagement and design. The NGT also helped us include the perspectives information from non-academic researchers that would not have been captured if the process had been limited to the research team. Conclusions: Developing ways for patients and other stakeholders to have a voice when it comes to developing patient awareness as related to mHealth may guide future research into engagement, ownership, usability and design. It is our intention that our paper be used and adapted by other researchers to engage small or vulnerable populations often excluded from mHealth research and design.None Declare

Which executive functioning deficits are associated with AD/HD, ODD/CD and comorbid AD/HD+ODD/CD?

Item does not contain fulltextThis study investigated (1) whether attention deficit/hyperactivity disorder (AD/HD) is associated with executive functioning (EF) deficits while controlling for oppositional defiant disorder/conduct disorder (ODD/CD), (2) whether ODD/CD is associated with EF deficits while controlling for AD/HD, and (3)~whether a combination of AD/HD and ODD/CD is associated with EF deficits (and the possibility that there is no association between EF deficits and AD/HD or ODD/CD in isolation). Subjects were 99~children ages 6–12 years. Three putative domains of EF were investigated using well-validated tests: verbal fluency, working memory, and planning. Independent of ODD/CD, AD/HD was associated with deficits in planning and working memory, but not in verbal fluency. Only teacher rated AD/HD, but not parent rated AD/HD, significantly contributed to the prediction of EF task performance. No EF deficits were associated with ODD/CD. The presence of comorbid AD/HD accounts for the EF deficits in children with comorbid AD/HD+ODD/CD. These results suggest that EF deficits are unique to AD/HD and support the model proposed by R. A. Barkley (1997).17 p

Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapy in 678 triple-negative primary breast cancers; results from the geparquinto study (GBG 44)†

Background We evaluated the pathological complete response (pCR) rate after neoadjuvant epirubicin, (E) cyclophosphamide (C) and docetaxel containing chemotherapy with and without the addition of bevacizumab in patients with triple-negative breast cancer (TNBC). Patients and methods Patients with untreated cT1c-4d TNBC represented a stratified subset of the 1948 participants of the HER2-negative part of the GeparQuinto trial. Patients were randomized to receive four cycles EC (90/600 mg/m2; q3w) followed by four cycles docetaxel (100 mg/m2; q3w) each with or without bevacizumab (15 mg/kg; q3w) added to chemotherapy. Results TNBC patients were randomized to chemotherapy without (n = 340) or with bevacizumab (n = 323). pCR (ypT0 ypN0, primary end point) rates were 27.9% without and 39.3% with bevacizumab (P = 0.003). According to other pCR definitions, the addition of bevacizumab increased the pCR rate from 30.9% to 41.8% (ypT0 ypN0/+; P = 0.004), 36.2% to 46.4% (ypT0/is ypN0/+; P = 0.009) and 32.9% to 43.3% (ypT0/is ypN0; P = 0.007). Bevacizumab treatment [OR 1.73, 95% confidence interval (CI) 1.23-2.42; P = 0.002], lower tumor stage (OR 2.38, 95% CI 1.24-4.54; P = 0.009) and grade 3 tumors (OR 1.68, 95% CI 1.14-2.48; P = 0.009) were confirmed as independent predictors of higher pCR in multivariate logistic regression analysis. Conclusions The addition of bevacizumab to chemotherapy in TNBC significantly increases pCR rate

The Studies of Garnet Deposits of Iran from Industrial Application Point of View

Garnet is a natural abrasive industrial mineral which produced by four producer In three countries. Garnets include igneous Rocks have formed under metamorphosed and limestone foliated . The most important of the garnet deposits of Iran is located in Koh-E-Gabri, Hamadan and Sangbast in Mashhad .In Iran Garnet is sold about 187$/t, but the range of price in other countries is approximately 160-280$/t. The information about Import and Export and determining the real price of Garnet in Iran is not avail-able definitely. According to the economical and engineer-ing evaluation accomplished on Garnets mine of Iran ,it shows that this mine with greatest Rate of Return ( IRR = 34 %) is one of the best and the most hopeful Garnets mine in Iran. the mines such as Azandrain and Sangbast in Mashahad haven't shown hopeful result Due to its nature