15 research outputs found
Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children
Get PDFWhat is Known
Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction.
What is New
In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes.
BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying.
Anal achalasia and constipation after Hirschsprung disease corrective surgery are very promising indications for BoNT use.
In selected children with resistant type of functional constipation and chronic anal fissure, BoNT is a viable option for treating
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Characterization of the Chemical Reactivity and Selectivity of DNA Bases Through the Use of DFT-Based Descriptors
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Comobid Medical and Psychiatric Disorders: Clinical and Economic Impact and Systems of Care
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