Fitting cosmological data to the function q(z)q(z) from GR Theory: Modified Chaplygin Gas

In the Friedmann cosmology the deceleration of the expansion $q$ plays a fundamental role. We derive the deceleration as a function of redshift $q(z)$ in two scenarios: $\Lambda$CDM model and modified Chaplygin gas ($MCG$) model. The function for the $MCG$ model is then fitted to the cosmological data in order to obtain the cosmological parameters that minimize $\chi^2$. We use the Fisher matrix to construct the covariance matrix of our parameters and reconstruct the q(z) function. We use Supernovae Ia, WMAP5 and BAO measurements to obtain the observational constraints. We determined the present acceleration as $q_0=-0.60 \pm 0.12$ for the $MCG$ model using the Constitution dataset of SNeIa and BAO, and $q_0=-0.63 \pm 0.17$ for the Union dataset and BAO. The transition redshift from deceleration to acceleration was found to be around $0.6$ for both datasets. We have also determined the dark energy parameter for the $MCG$ model: $\Omega_{X0}=0.834 \pm 0.028$ for the Constitution dataset and $\Omega_{X0}=0.854 \pm 0.036$ using the Union dataset.Comment: 14 page

Testing dark matter warmness and quantity via the reduced relativistic gas model

We use the framework of a recently proposed model of reduced relativistic gas (RRG) to obtain the bounds for $\Omega$'s of Dark Matter and Dark Energy (in the present case, a cosmological constant), taking into consideration an arbitrary warmness of Dark Matter. An equivalent equation of state has been used by Sakharov to predict the oscillations in the matter power spectrum. Two kind of tests are accounted for in what follows, namely the ones coming from the dynamics of the conformal factor of the homogeneous and isotropic metric and also the ones based on linear cosmic perturbations. The RRG model demonstrated its high effectiveness, permitting to explore a large volume in the space of mentioned parameters in a rather economic way. Taking together the results of such tests as Supernova type Ia (Union2 sample), $H(z)$, CMB ($R$ factor), BAO and LSS (2dfGRS data), we confirm that \LaCDM is the most favored model. At the same time, for the 2dfGRS data alone we found that an alternative model with a very small quantity of a Dark Matter is also viable. This output is potentially relevant in view of the fact that the LSS is the only test which can not be affected by the possible quantum contributions to the low-energy gravitational action.Comment: 16 pages accepted for publication in PR

Interacting photon-baryon fluid, warm dark matter and the first acoustic peak

The Reduced Relativistic Gas (RRG) model was introduced by A. Sakharov in 1965 for deriving the cosmic microwave background (CMB) spectrum. It was recently reinvented by some of us to achieve an interpolation between the radiation and dust epochs in the evolution of the Universe. This model circumvents the complicated structure of the Boltzmann-Einstein system of equations and admits a transparent description of warm-dark-matter effects. It is extended here to include, on a phenomenological basis, an out-of-equilibrium interaction between radiation and baryons which is supposed to account for relevant aspects of pre-recombination physics in a simplified manner. Furthermore, we use the tight-coupling approximation to explore the influence of both this interaction and of the RRG warmness parameter on the anisotropy spectrum of the CMB. The predictions of the model are very similar to those of the {\Lambda}CDM model if both the interaction and the dark-matter warmness parameters are of the order of $10^{-4}$ or smaller. As far as the warmness parameter is concerned, this is in good agreement with previous estimations on the basis of results from structure formation.Comment: 10 pages and 4 figure

Carbon and oxygen in HII regions of the Magellanic Clouds: abundance discrepancy and chemical evolution

We present C and O abundances in the Magellanic Clouds derived from deep spectra of HII regions. The data have been taken with the Ultraviolet-Visual Echelle Spectrograph at the 8.2-m VLT. The sample comprises 5 HII regions in the Large Magellanic Cloud (LMC) and 4 in the Small Magellanic Cloud (SMC). We measure pure recombination lines (RLs) of CII and OII in all the objects, permitting to derive the abundance discrepancy factors (ADFs) for O^2+, as well as their O/H, C/H and C/O ratios. We compare the ADFs with those of other HII regions in different galaxies. The results suggest a possible metallicity dependence of the ADF for the low-metallicity objects, but more uncertain for high-metallicity objects. We compare nebular and B-type stellar abundances and we find that the stellar abundances agree better with the nebular ones derived from collisionally excited lines (CELs). Comparing these results with other galaxies we observe that stellar abundances seem to agree better with the nebular ones derived from CELs in low-metallicity environments and from RLs in high-metallicity environments. The C/H, O/H and C/O ratios show almost flat radial gradients, in contrast with the spiral galaxies where such gradients are negative. We explore the chemical evolution analysing C/O vs. O/H and comparing with the results of HII regions in other galaxies. The LMC seems to show a similar chemical evolution to the external zones of small spiral galaxies and the SMC behaves as a typical star-forming dwarf galaxy.Comment: Accepted for publication in MNRAS, 17 pages, 11 figures, 8 table

Overexpression of mitochondrial if1 prevents metastatic disease of colorectal cancer by enhancing anoikis and tumor infiltration of NK cells

Increasing evidences show that the ATPase Inhibitory Factor 1 (IF1), the physiological inhibitor of the ATP synthase, is overexpressed in a large number of carcinomas contributing to metabolic reprogramming and cancer progression. Herein, we show that in contrast to the findings in other carcinomas, the overexpression of IF1 in a cohort of colorectal carcinomas (CRC) predicts less chances of disease recurrence, IF1 being an independent predictor of survival. Bioinformatic and gene expression analyses of the transcriptome of colon cancer cells with differential expression of IF1 indicate that cells overexpressing IF1 display a less aggressive behavior than IF1 silenced (shIF1) cells. Proteomic and functional in vitro migration and invasion assays confirmed the higher tumorigenic potential of shIF1 cells. Moreover, shIF1 cells have increased in vivo metastatic potential. The higher metastatic potential of shIF1 cells relies on increased cFLIP-mediated resistance to undergo anoikis after cell detachment. Furthermore, tumor spheroids of shIF1 cells have an increased ability to escape from immune surveillance by NK cells. Altogether, the results reveal that the overexpression of IF1 acts as a tumor suppressor in CRC with an important anti-metastatic role, thus supporting IF1 as a potential therapeutic target in CRCThis research was funded by grants from Ministerio de Ciencia, Innovación y Universidades (SAF2013-41945-R, SAF2016-75916-R and SAF2016-75452-R), CIBERER-ISCIII (CB06/07/0017) and Fundación Ramón Areces, Spai

Energy and angular momentum of the gravitational field in the teleparallel geometry

The Hamiltonian formulation of the teleparallel equivalent of general relativity is considered. Definitions of energy, momentum and angular momentum of the gravitational field arise from the integral form of the constraint equations of the theory. In particular, the gravitational energy-momentum is given by the integral of scalar densities over a three-dimensional spacelike hypersurface. The definition for the gravitational energy is investigated in the context of the Kerr black hole. In the evaluation of the energy contained within the external event horizon of the Kerr black hole we obtain a value strikingly close to the irreducible mass of the latter. The gravitational angular momentum is evaluated for the gravitational field of a thin, slowly rotating mass shell.Comment: 33 pages, Latex file, 1 figure, to appear in the Phys. Rev.