A realistic evaluation of indoor positioning systems based on Wi-Fi fingerprinting: The 2015 EvAAL–ETRI competition

Pre-print versionThis paper presents results from comparing different Wi-Fi fingerprinting algorithms on the same private dataset. The algorithms where realized by independent teams in the frame of the off-site track of the EvAAL-ETRI Indoor Localization Competition which was part of the Sixth International Conference on Indoor Positioning and Indoor Navigation (IPIN 2015). Competitors designed and validated their algorithms against the publicly available UJIIndoorLoc database which contains a huge reference- and validation data set. All competing systems were evaluated using the mean error in positioning, with penalties, using a private test dataset. The authors believe that this is the first work in which Wi-Fi fingerprinting algorithm results delivered by several independent and competing teams are fairly compared under the same evaluation conditions. The analysis also comprises a combined approach: Results indicate that the competing systems where complementary, since an ensemble that combines three competing methods reported the overall best results.We would like to thank Francesco Potortì, Paolo Barsocchi, Michele Girolami and Kyle O’Keefe for their valuable help in organizing and spread the EVAALETRI competition and the off-site track. We would also like to thank the TPC members Machaj Juraj, Christos Laoudias, Antoni Pérez-Navarro and Robert Piché for their valuable comments, suggestions and reviews. Parts of this work were funded in the frame of the Spanish Ministry of Economy and Competitiveness through the “Metodologiías avanzadas para el diseño, desarrollo, evaluación e integración de algoritmos de localización en interiores” project (Proyectos I+D Excelencia, código TIN2015-70202-P) and the “Red de Posicionamiento y Navegación en Interiores” network (Redes de Excelencia, código TEC2015-71426- REDT). Parts of this work were funded in the frame of the German federal Ministry of Education and Research programme "FHprofUnt2013" under contract 03FH035PB3 (Project SPIRIT).info:eu-repo/semantics/acceptedVersio

Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57

BackgroundTransient neonatal diabetes mellitus 1 (TNDM1) is a rare imprinting disorder characterized by intrautering growth retardation and diabetes mellitus usually presenting within the first six weeks of life and resolves by the age of 18 months. However, patients have an increased risk of developing diabetes mellitus type 2 later in life. Transient neonatal diabetes mellitus 1 is caused by overexpression of the maternally imprinted genes PLAGL1 and HYMAI on chromosome 6q24. One of the mechanisms leading to overexpression of the locus is hypomethylation of the maternal allele of PLAGL1 and HYMAI. A subset of patients with maternal hypomethylation at PLAGL1 have hypomethylation at additional imprinted loci throughout the genome, including GRB10, ZIM2 (PEG3), MEST (PEG1), KCNQ1OT1 and NESPAS (GNAS-AS1). About half of the TNDM1 patients carry mutations in ZFP57, a transcription factor involved in establishment and maintenance of methylation of imprinted loci. Our objective was to investigate whether additional regions are aberrantly methylated in ZFP57 mutation carriers.MethodsGenome-wide DNA methylation analysis was performed on four individuals with homozygous or compound heterozygous ZFP57 mutations, three relatives with heterozygous ZFP57 mutations and five controls. Methylation status of selected regions showing aberrant methylation in the patients was verified using bisulfite-sequencing.ResultsWe found large variability among the patients concerning the number and identity of the differentially methylated regions, but more than 60 regions were aberrantly methylated in two or more patients and a novel region within PPP1R13L was found to be hypomethylated in all the patients. The hypomethylated regions in common between the patients are enriched for the ZFP57 DNA binding motif.ConclusionsWe have expanded the epimutational spectrum of TNDM1 associated with ZFP57 mutations and found one novel region within PPP1R13L which is hypomethylated in all TNDM1 patients included in this study. Functional studies of the locus might provide further insight into the etiology of the disease.<br/

Event Detection in Aerospace Systems using Centralized Sensor Networks: A Comparative Study of Several Methodologies

Recent advances in micro electromechanical systems technology, digital electronics, and wireless communications have enabled development of low-cost, low-power, multifunctional miniature smart sensors. These sensors can be deployed throughout a region in an aerospace vehicle to build a network for measurement, detection and surveillance applications. Event detection using such centralized sensor networks is often regarded as one of the most promising health management technologies in aerospace applications where timely detection of local anomalies has a great impact on the safety of the mission. In this paper, we propose to conduct a qualitative comparison of several local event detection algorithms for centralized redundant sensor networks. The algorithms are compared with respect to their ability to locate and evaluate an event in the presence of noise and sensor failures for various node geometries and densities

FiberGLAST: a scintillating fiber approach to the GLAST mission

FiberGLAST is a scintillating fiber gamma-ray detector designed for the GLAST mission. The system described below provides superior effective area and field of view for modest cost and risk. An overview of the FiberGLAST instrument is presented, as well as a more detailed description of the principle elements of the primary detector volume. The triggering and readout electronics are described, and Monte Carlo Simulations of the instrument performance are presented

Milagrito Detection of TeV Emission from Mrk 501

The Milagro water Cherenkov detector near Los Alamos, New Mexico, has been operated as a sky monitor at energies of a few TeV between February 1997 and April 1998. Serving as a test run for the full Milagro detector, Milagrito has taken data during the strong and long-lasting 1997 flare of Mrk 501. We present results from the analysis of Mrk 501 and compare the excess and background rates with expectations from the detector simulations.Comment: 4 pages, submitted to XXVI International Cosmic Ray Conference, Salt Lake Cit

Results from the Milagrito experiment

The Milagro water Cherenkov detector near Los Alamos, New Mexico is the first air shower detector capable of continuously monitoring the sky at energies between 500 GeV and 20 TeV. Preliminary results of the Milagro experiment are presented. A predecessor of the Milagro detector, Milagrito, was operational from February 1997 to May 1998. Milagrito consisted of 228 8″ photomultiplier tubes (PMTs) arranged in a grid with a 2.8 meter spacing and submerged in 1–2 meters of water. During its operation, Milagrito collected in excess of 9 billion events with a median energy of about 3 TeV. The detector’s sensitivity extends below 1 TeV for showers from near zenith. The results of an all sky search for the Milagrito data for both transient and DC sources will be presented, including the Crab Nebula and active galaxies Markarian 501 and 421, which are known sources of TeV gamma-rays. Also presented will be a study of the TeV emission from gamma ray bursts (GRBs) in Milagrito’s field of view detected by the BATSE experiment on the Compton Gamma-Ray Observatory

Calibration of the Milagro Cosmic Ray Telescope

The Milagro detector is an air shower array which uses the water Cherenkov technique and is capable of continuously monitoring the sky at energies near 1 TeV. The detector consists of 20000 metric tons of pure water instrumented with 723 photo-multiplier tubes (PMTs). The PMTs are arranged in a two-layer structure on a lattice of 3 m spacing covering 5000 $m^2$ area. The direction of the shower is determined from the relative timing of the PMT signals, necessitating a common time reference and amplitude slewing corrections to improve the time resolution. The calibration system to provide these consists of a pulsed laser driving 30 diffusing light sources deployed in the pond to allow cross-calibration of the PMTs. The system is capable of calibrating times and the pulse-heights from the PMTs using the time-over-threshold technique. The absolute energy scale is provided using single muons passing through the detector. The description of the calibration system of the Milagro detector and its prototype Milagrito will be presented.Comment: 4 pages, submitted to the XXVI International Cosmic Ray Conferenc

The high-energy gamma-ray fluence and energy spectrum of GRB 970417a from observations with Milagrito

Evidence of TeV emission from GRB970417a has been previously reported using data from the Milagrito detector. Constraints on the TeV fluence and the energy spectrum are now derived using additional data from a scaler system that recorded the rate of signals from the Milagrito photomultipliers. This analysis shows that if emission from GRB970417a has been observed, it must contain photons with energies above 650 GeV. Some consequences of this observation are discussed.Comment: Submitted to the Astrophysical Journa