Exploring galaxy evolution with generative models

Context. Generative models open up the possibility to interrogate scientific data in a more data-driven way. Aims: We propose a method that uses generative models to explore hypotheses in astrophysics and other areas. We use a neural network to show how we can independently manipulate physical attributes by encoding objects in latent space. Methods: By learning a latent space representation of the data, we can use this network to forward model and explore hypotheses in a data-driven way. We train a neural network to generate artificial data to test hypotheses for the underlying physical processes. Results: We demonstrate this process using a well-studied process in astrophysics, the quenching of star formation in galaxies as they move from low-to high-density environments. This approach can help explore astrophysical and other phenomena in a way that is different from current methods based on simulations and observations.Comment: Published in A&A. For code and further details, see http://space.ml/proj/explor

Normativity, Realism and Emotional Experience

Norms are standards against which actions, dispositions of mind and character, states of affairs and so forth can be measured. They also govern our behaviour, make claims on us, bind us and provide reasons for action and thought that motivate us. J. L. Mackie argued that the intrinsic prescriptivity, or to-be-pursuedness, of moral norms would make them utterly unlike anything else that we know of. Therefore, we should favour an error theory of morality. Mackie thought that the to-be-pursuedness would have to be built into mind-independent moral reality. One alternative, however, is that the to-be-pursuedness is built into our faculty of moral sensibility. There is a large body of empirical evidence demonstrating that the emotions play a central role in making moral judgments. I shall argue that this helps to explain how normative judgments are reliably and non-accidentally related to motivation. I shall also argue that emotional experience has the right structure and properties to provide us with a defeasible warrant for normative knowledge. The role of the emotions in our moral psychology does not obviously support anti-realism. Rather, emotional experience can be intentional, evaluative, evaluable, and quasi-perceptual. This makes emotional experience a plausible candidate for constituting a non-queer faculty of moral sensibility

Pain management procedures used by dental and maxillofacial surgeons: an investigation with special regard to odontalgia

BACKGROUND: Little is known about the procedures used by German dental and maxillofacial surgeons treating patients suffering from chronic orofacial pain (COP). This study aimed to evaluate the ambulatory management of COP. METHODS: Using a standardized questionnaire we collected data of dental and maxillofacial surgeons treating patients with COP. Therapists described variables as patients' demographics, chronic pain disorders and their aetiologies, own diagnostic and treatment principles during a period of 3 months. RESULTS: Although only 13.5% of the 520 addressed therapists returned completely evaluable questionnaires, 985 patients with COP could be identified. An orofacial pain syndrome named atypical odontalgia (17.0 %) was frequent. Although those patients revealed signs of chronification, pain therapists were rarely involved (12.5%). For assessing pain the use of Analogue Scales (7%) or interventional diagnostics (4.6%) was uncommon. Despite the fact that surgical procedures are cofactors of COP therapists preferred further surgery (41.9%) and neglected the prescription of analgesics (15.7%). However, most therapists self-evaluated the efficacy of their pain management as good (69.7 %). CONCLUSION: Often ambulatory dental and maxillofacial surgeons do not follow guidelines for COP management despite a high prevalence of severe orofacial pain syndromes

Narrative Skin Repair: Bearing Witness to Mediatized Representations of Self-Harm

Postprint version

Likely country of origin in publications on randomised controlled trials and controlled clinical trials during the last 60 years

BACKGROUND: The number of publications on clinical trials is unknown as well as the countries publishing most trial reports. To try to examine these questions we performed an ecological study. METHODS: We searched the 454,449 records on publications in The Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, Issue 3, 2005 (CD-ROM version) for possible country of origin. We inspected a random sample of 906 records for information on country and type of trial. RESULTS: There was an exponential growth of publications on randomised controlled trials and controlled clinical trials since 1946, but the growth seems to have seized since 2000. We identified the possible country of origin of 210,974 publications (46.4%). The USA is leading with about 46,789 publications followed by UK, Germany, Italy, the Netherlands, Canada, and France. Sweden becomes the leader with 891 publications per million inhabitants during the last 60 years followed by Denmark (n = 864), New Zealand (n = 791), Finland (n = 781), the Netherlands (n = 570), Switzerland (n = 547), and Norway (n = 543). In depth assessment of the random sample backed these findings. CONCLUSION: Many records lacked country of origin, even after the additional scrutiny. The number of publications on clinical trials increased exponentially until the turn of the century. Rather small, democratic, and wealthy countries take the lead when the number of publications on clinical trials is calculated based on million inhabitants. If all countries produced the same number of trials as these countries, this could mean thousands of new effective treatments during the next 60 years