Impregnated nets cannot fully substitute for DDT : field effectiveness of Malaria prevention in Solomon Islands

The incidence of malaria in Solomon Islands has been declining since 1992, but there is a large geographical variation between areas in the incidence level and the rate of decline. The authors used a mix of control interventions, including DDT residual house spraying and insecticide-treated mosquito nets. Data on monthly incidence and control activities performed from January 1993 to August 1999 were gathered for 41 out of the 110 malaria zones in the country. Monthly reports on the number of fevers seen at outpatient health clinics in the same zones over the same period were also extracted from the clinical health information system. The authors used multivariate random effects regression, including calendar month as an instrumental variable, to investigate the relationship between the number of malaria or fever cases and the control measures applied by month and zone, while adjusting for rainfall and proximity to water. The results showed that DDT house spraying, insecticide treatment of nets, and education about malaria were all independently associated with reduction in incident cases of malaria or fever, while larviciding with temephos was not. This was true for confirmed malaria cases even when a variable representing the passage of time was included in the models. The results show how much each method used was contributing to malaria control in Solomon Islands and how it can be used to design the most cost-effective package of interventions. The evidence suggests that impregnated bednets cannot easily replace DDT spraying without substantial increase in incidence, but impregnated nets do permit a substantial reduction in the amount of DDT spraying.Health Monitoring&Evaluation,Public Health Promotion,Climate Change,Disease Control&Prevention,Early Child and Children's Health,Health Monitoring&Evaluation,Climate Change,Malaria,Early Child and Children's Health,Health Indicators

The edible oyster culture

In 1970s the CMFR Institute initiated oyster culture through rack and tray method. Large scale spat collection, preparation of spat collectors, season and seed availability were studied. In 1980, a hatchery was set up with annual production capacity of one million edible oyster seed and the techniques involved in hatchery system were standardized. The seed were supplied to other centres of this Institute and Gujarat Fisheries Department. The production rates for rack and tray, string and stake method were estimated as 120 t and 22 t respectively. As part of extension, one lab to land programme, 8 training programmes, one workshop and a summer insitute were conducted. Results of experimental oyster culture work carried out at Mandapam, Madras, Bheemunipatnam, Kakinada, Mulki, Dharmadam, Ashtamudi and Cochin backwaters are given. Rearing 600 strings in 0.04 ha at Ashtamudi and harvesting 2.5t oysters pointed out 44.8% return with estimated production of 80- 105t/ha. Further research priorities on oyster culture aspects are indicated

Ranching of clams in the Ashtamudi lake

Ranching of clams in the Ashtamudi lak

Clam resource in the Astamudi Lake, a tropical estuary in sourthern India: Managment and conservation concerns

Clam resources form the livelihood of more than five hundred families in and around Ashtamudi Lake, situated between latitude 8°45' - 9°28' N and 76°28 - 77" 17' E. The alarming increase in the exploitation of Paphia malabarica in the recent years forced the Government of Kerala to impose ban on the fishing activities during its breeding season based on the recommendations of CMFRI in 1993

Biometric relationships of the black-lip pearl oyster Pinctada margaritifera (Linnaeus, 1758) from the Andaman and Nicobar waters

The black-lip pearl oyster, Pinctada margaritifera is widely distributed in Indo-Pacific region and has prime importance in the production of black pearls. In India, its natural occurrence is confined to the Andaman and Nicobar Islands. The biometric relationships between (dorso-ventral measurement [DVM] and Hinge Length [HL]; Thickness [THK] and Total Weight [TWT]) were studied from 458 oysters collected from these islands which were grouped in to 5 length classes. In all size groups, there was increase in weight with increase in length. The highest coefficient (r2=0.7828) was obtained for the animals with DVM ranging from 76 to 95 mm. The correlation coefficient ‘r’ was low for DVM-HL and slightly higher for DVM-THK. Comparisons of biometric relationships of the natural populations of the Indian pearl oysters with that of farmed oysters in other regions indicated xenomorphism in pearl oysters in Andaman and Nicobar Islands due to restricted space in natural habitats

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein

Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain Barre syndrome. C. jejuni is asaccharolytic because it lacks an active glycolytic pathway for the use of sugars as a carbon source. This suggests an increased reliance on amino acids as nutrients and indeed the genome sequence of this organism indicates the presence of a number of amino acid uptake systems. Cj0982, also known as CjaA, is a putative extracytoplasmic solute receptor for one such uptake system as well as a major surface antigen and vaccine candidate. The crystal structure of Cj0982 reveals a two-domain protein with density in the enclosed cavity between the domains that clearly defines the presence of a bound cysteine ligand. Fluorescence titration experiments were used to demonstrate that Cj0982 binds cysteine tightly and specifically with a K-d of similar to 10(-7) M consistent with a role as a receptor for a high- affinity transporter. These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni

Interferon regulatory factor 8-deficiency determines massive neutrophil recruitment but T cell defect in fast growing granulomas during tuberculosis

Following Mycobacterium tuberculosis (Mtb) infection, immune cell recruitment in lungs is pivotal in establishing protective immunity through granuloma formation and neogenesis of lymphoid structures (LS). Interferon regulatory factor-8 (IRF-8) plays an important role in host defense against Mtb, although the mechanisms driving anti-mycobacterial immunity remain unclear. In this study, IRF-8 deficient mice (IRF-8−/−) were aerogenously infected with a low-dose Mtb Erdman virulent strain and the course of infection was compared with that induced in wild-type (WT-B6) counterparts. Tuberculosis (TB) progression was examined in both groups using pathological, microbiological and immunological parameters. Following Mtb exposure, the bacterial load in lungs and spleens progressed comparably in the two groups for two weeks, after which IRF-8−/− mice developed a fatal acute TB whereas in WT-B6 the disease reached a chronic stage. In lungs of IRF-8−/−, uncontrolled growth of pulmonary granulomas and impaired development of LS were observed, associated with unbalanced homeostatic chemokines, progressive loss of infiltrating T lymphocytes and massive prevalence of neutrophils at late infection stages. Our data define IRF-8 as an essential factor for the maintenance of proper immune cell recruitment in granulomas and LS required to restrain Mtb infection. Moreover, IRF-8−/− mice, relying on a common human and mouse genetic mutation linked to susceptibility/severity of mycobacterial diseases, represent a valuable model of acute TB for comparative studies with chronically-infected congenic WT-B6 for dissecting protective and pathological immune reactions

Survey of green mussel seed resources of Kerala and Karnataka

Farming of marine mussels Is practiced extensively in the temperate and Southeast Asian countries. In India two species of mussels, Perna viridis and Perna indica commonly known as the green and brown mussels respectively have been reported

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer\u27s disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, \u27shape connections\u27 between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus