Evaluation of global impact models' ability to reproduce runoff characteristics over the central United States

The central United States experiences a wide array of hydrological extremes, with the 1993, 2008, 2013, and 2014 flooding events and the 1988 and 2012 droughts representing some of the most recent extremes, and is an area where water availability is critical for agricultural production. This study aims to evaluate the ability of a set of global impact models (GIMs) from the Water Model Intercomparison Project to reproduce the regional hydrology of the central United States for the period 1963–2001. Hydrological indices describing annual daily maximum, medium and minimum flow, and their timing are extracted from both modeled daily runoff data by nine GIMs and from observed daily streamflow measured at 252 river gauges. We compare trend patterns for these indices, and their ability to capture runoff volume differences for the 1988 drought and 1993 flood. In addition, we use a subset of 128 gauges and corresponding grid cells to perform a detailed evaluation of the models on a gauge-to-grid cell basis. Results indicate that these GIMs capture the overall trends in high, medium, and low flows well. However, the models differ from observations with respect to the timing of high and medium flows. More specifically, GIMs that only include water balance tend to be closer to the observations than GIMs that also include the energy balance. In general, as it would be expected, the performance of the GIMs is the best when describing medium flows, as opposed to the two ends of the runoff spectrum. With regards to low flows, some of the GIMs have considerably large pools of zeros or low values in their time series, undermining their ability in capturing low flow characteristics and weakening the ensemble's output. Overall, this study provides a valuable examination of the capability of GIMs to reproduce observed regional hydrology over a range of quantities for the central United States

Community-based participatory research to improve life quality and clinical outcomes of patients with breast cancer (DianaWeb in Umbria pilot study)

Introduction Breast cancer (BC) is the most frequent cancer in Europe and the International Agency for Research on Cancer (IARC) has estimated over 460 000 incident cases per year. Survival among patients with BC has increased in the past decades and EUROCARE-5 has estimated a 5-year relative survival rate of 82% for patients diagnosed in 2000-2007. There is growing evidence that lifestyle (such as a diet based on Mediterranean principles associated with moderate physical activity) may influence prognosis of BC; however, this information is not currently available to patients and is not considered in oncology protocols. Only a few epidemiological studies have investigated the role of diet in BC recurrence and metastasis. Methods and analysis DianaWeb is a community-based participatory research dedicated to patients with BC and represents a collaborative effort between participants and research institutions to determine if specified changes in lifestyle would result in improved outcomes in terms of quality of life or survival. The aim of the study is to recruit a large number of participants, to monitor their lifestyle and health status over time, to provide them tips to encourage sustainable lifestyle changes, to analyse clinical outcomes as a function of baseline risk factors and subsequent changes, and to share with patients methodologies and results. DianaWeb uses a specific interactive website (http://www.dianaweb.org/) and, with very few exceptions, all communications will be made through the web. In this paper we describe the pilot study, namely DianaWeb in Umbria. Ethics and dissemination DianaWeb does not interfere with prescribed oncological treatments; rather, it recommends that participants should follow the received prescriptions. The results will be used to plan guidelines for nutrition and physical activity for patients with BC

Cardiovascular diseases and hard drinking waters : Implications from a systematic review with meta-analysis of case-control studies

This systematic review with meta-analysis, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, aims at evaluating the potential correlation between magnesium and calcium concentration in drinking waters and the risk of cardiovascular diseases (CVD), which impose a considerable burden in high-income countries. Included studies were of the case-control studies type. From an initial list of 643 potentially eligible articles, seven studies were finally retained in the quantitative analysis. Since each one of them assessed different ion concentrations, subjects exposed to the highest concentration versus those exposed to the lowest concentration were compared. By including an overall figure of 44,000 subjects, the result suggests a protective effect of the ions on CVD prevention, with an effect-size (ES) of 0.82 (95% confidence interval CI = [0.70-0.95], p-value = 0.008) for calcium, and ES = 0.75 (95% CI = [0.66-0.86], p-value= 0.000) for magnesium. Hard water consumption seems to be protective against CVD. However, the high heterogeneity (I2 = 75.24, p-value= 0.001 for calcium; I2 = 72.96, p-value= 0.0024 for magnesium) and the existence of publication bias limits the robustness and generalizability of these findings. Further high-quality studies are needed to reproduce and confirm these results

Parametric experimental tests of steam gasification of pine wood in a fluidized bed reactor

Among Renewable Energy Sources (RES), biomass represent one of the most common and suitable solution in order to contribute to the global energy supply and to reduce greenhouse gases (GHG) emissions. The disposal of some residual biomass, as pruning from pine trees, represent a problem for agricultural and agro-industrial sectors. But if the residual biomass are used for energy production can become a resource. The most suitable energy conversion technology for the above-mentioned biomass is gasification process because the high C/N ratio and the low moisture content, obtained from the analysis. In this work a small-pilot bubbling-bed gasification plant has been designed, constructed and used in order to obtain, from the pine trees pruning, a syngas with low tar and char contents and high hydrogen content. The activities showed here are part of the activities carried out in the European 7FP UNIfHY project. In particular the aim of this work is to develop experimental test on a bench scale steam blown fluidized bed biomass gasifier. These tests will be utilized in future works for the simulations of a pilot scale steam fluidized bed gasifier (100 kWth) fed with different biomass feedstock. The results of the tests include produced gas and tar composition as well gas, tar and char yield. Tests on a bench scale reactor (8 cm I.D.) were carried out varying steam to biomass ratio from 0.5, 0.7 and 1 to 830°C

"PErCEIVE in Umbria" : Evaluation of anti-influenza vaccination's perception among Umbrian pharmacists

Vaccines recommendations are available for both healthcare professionals and the general public, but although the vaccination is the most effective method to prevent infectious diseases, the coverage is still behind the recommended rate. In Italy, according to a recent study, the anti-flu vaccination rate among healthcare worker range between 9% to 30%. The aim of our study was to identify knowledge, attitude and behaviours regarding influenza vaccination among community pharmacists in order to increase the coverage rate among healthcare professional. "PErCEIVE (Pharmacist Perception on Influenza Vaccine) in Umbria" was a cross sectional survey among community pharmacists in Umbria conducted between 16th November 2015 to 29th February 2016. The questionnaire was anonymous, on-line self-administered survey. Statistical analysis were performed using STATA/SE 12 software. The response rate was 28.91% (n = 72/249). Among the studied population 76.39% (n = 55) had never performed influenza vaccine during the previous 5 years. Regarding source of information, only 15.28% of the subjects (n = 11) consulted the scientific publications, vs 52.78% (n = 38) who did not show any kind of interest upon the influenza vaccine. Our results show a low attitude to be vaccinated among pharmacists together with a low grade of awareness regarding the important role that pharmacists might play in order to reduce influenza burden, to promote health literacy among their patients and to decrease the risk of patients infection. Pharmacists might be crucial healthcare workers involved in health promotion, in vaccines' uptake and practices progression

Cluster analysis of downscaled and explicitly simulated North Atlantic tropical cyclone tracks

A realistic representation of the North Atlantic tropical cyclone tracks is crucial as it allows, for example, explaining potential changes in US landfalling systems. Here we present a tentative study, which examines the ability of recent climate models to represent North Atlantic tropical cyclone tracks. Tracks from two types of climate models are evaluated: explicit tracks are obtained from tropical cyclones simulated in regional or global climate models with moderate to high horizontal resolution (1° to 0.25°), and downscaled tracks are obtained using a downscaling technique with large-scale environmental fields from a subset of these models. For both configurations, tracks are objectively separated into four groups using a cluster technique, leading to a zonal and a meridional separation of the tracks. The meridional separation largely captures the separation between deep tropical and sub-tropical, hybrid or baroclinic cyclones, while the zonal separation segregates Gulf of Mexico and Cape Verde storms. The properties of the tracks’ seasonality, intensity and power dissipation index in each cluster are documented for both configurations. Our results show that except for the seasonality, the downscaled tracks better capture the observed characteristics of the clusters. We also use three different idealized scenarios to examine the possible future changes of tropical cyclone tracks under 1) warming sea surface temperature, 2) increasing carbon dioxide, and 3) a combination of the two. The response to each scenario is highly variable depending on the simulation considered. Finally, we examine the role of each cluster in these future changes and find no preponderant contribution of any single cluster over the others

Sulforaphane and Epigallocatechin Gallate Restore Estrogen Receptor Expression by Modulating Epigenetic Events in the Breast Cancer Cell Line MDA-MB-231 : A Systematic Review and Meta-Analysis

Background/Aims: Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro. Methods: Due to the enormous variability observed in study protocols and the innumerable genes involved, only studies analyzing the number of apoptotic cells in the MDA-MB-231 cell line were evaluated. The effect size (ES) was computed as the ratio of means. Results: We identified 7 studies, 4 regarding the effect of 10 μM SFN on MDA-MB-231 cells (ES = 4.59, 95% confidence interval 4.05-5.20) and 3 focusing on the impact of 20 μM EGCG (ES = 2.84, 95% confidence interval 2.60-3.10). Conclusion: The findings suggest beneficial effects of dietary bioactive compounds such as SFN and EGCG and their effect on BC cells by restoring estrogen receptor gene expression, modulating epigenetic changes and events, and interfering with tumor growth rate. Publication bias limits the generalizability of the conclusions. High-quality studies are needed

Patata Rossa di Colfiorito IGP (Solanum tuberosum, L.) and health-promoting potentialities: Do cooking techniques and storage affect chemical profile and antioxidant activity?

Acting as ' antioxidants ', phenolic compounds have been shown to have a potential protective effect against a wide range of noncommunicable diseases. However, their content in plant-based products - and, in turn, their potential benefits - might be affected by the thermal procedures used in food cooking. In light of this, the aim of this work was a characterization of Patata Rossa di Colfiorito (PRC, an Italian PGI red-skinned potato) and an investigation of the impact of cooking and storage on its bioactive compounds, phenolic content, and antioxidant activity. After the harvesting (T-0), samples were analyzed using instrumental analysis (e.g., HPLC-ESI-MS/MS) and a set of chemical assays (total phenolic content, 2,2-Diphenyl-1-picrylhydrazyl - DPPH, 2,2 '-azino-bis(3 '-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) - ABTS, and oxygen radical absorbance capacity - ORAC assays). Analyses were also performed on boiled, pressure-cooked and one-month-stored (T-1) products. A commercial red-skinned potato (RSP) was also analyzed.Overall, compared with the raw product, both boiling and pressure-cooking led to a significant increase in bioactive compounds (raw: 168.15 mg kg(-1) of fresh matter, FM; boiled: 398.92 mg kg(-1) FM; pressure-cooked: 309.24 mg kg(-1) FM), total phenolic content and antioxidant activity measured by DPPH and ABTS assays. PRC samples showed higher content in bioactive compounds, TPC values and antioxidant activity compared with commercial RSP (with some sporadic exceptions in ORAC values). Interestingly, one month of domestic storage did not affect the freshly harvested product's features.In conclusion, these results highlighted the quality of this local product and its property to withstand thermal processing and storage. We believe that the results we have obtained should be taken into consideration by health professionals, at both local and national levels, and that PRC deserves to be further studied to investigate its potential human health benefits, as well