Review on the epidemiology and dynamics of BSE epidemics

The paper describes how the comprehensive surveillance of bovine spongiform encephalopathy (BSE) and studies carried out on these data has enhanced our knowledge of the epidemiology of BSE. Around 7 000 BSE cases were detected through the screening of about 50 million cattle with rapid tests in Europe. It confirmed that the clinical surveillance had a poor capacity to detect cases, and also showed the discrepancy of this passive surveillance efficiency between regions and production types (dairy/beef). Other risk factors for BSE were being in a dairy herd (three times more than beef), having a young age at first calving (for dairy cattle), being autumn-born (dairy and beef), and being in a herd with a very high milk yield. These findings focus the risk on the feeding regimen of calves/heifers. Several epidemiological studies across countries suggest that the feedborne source related to meat and bone meal (MBM) is the only substantiated route of infection ¿ even after the feed ban ¿, while it is not possible to exclude maternal transmission or milk replacers as a source of some infections. In most European countries, the average age of the cases is increasing over time and the prevalence decreasing, which reflects the effectiveness of control measures. Consistent results on the trend of the epidemic were obtained using back-calculation modelling, the R0 approach and Age-Period-Cohort models. Furthermore, active surveillance also resulted in the finding of atypical cases. These are distinct from previously found BSE and classified in two different forms based on biochemical characteristics; their prevalence is very low (36 cases up to 1st September 2007), affected animals were old and some of them displayed clinical signs. The origin and possibility of natural transmission is unknown

Participatory simulation for coordination awareness concerning small water infrastructure and drought adaptation planning in semi-arid Mozambique

In semi-arid area where water is scarce and natural resources constraints often limit rural livelihoods opportunities, Small Water Infrastructures (SWI) are essential to the local development. However the expansion of SW I raises new challenges as many small dispersed point of water extraction are difficult to adequately control and regulate. This brings the attention to the planning of SWI development planning along with the classical and non resolved issue of their long term sustainability. This paper argues that a participatory modelling and simulation approaches helps local actors to better understand the interactions between resources and actors strategies which in time could contribute to an integrative planning processes. It draws on a companion modelling approach using the Wat-A-Gale tool kit. The results of this pilot project show that the participants could acknowledge the local complexity associated with their livelihood strategies. In addition, some participants who had been included i n the overal I process and could more easi I y extrapolate were able to reflect on local integrative planning. (Résumé d'auteur

Land and water management in the metropolitan region of Sao Paulo: Presentation of the geographic and institutional context.

The most populated and industrialized region of Latin America, the Metropolitan Region of São Paulo host 18 millions people in 39 municipalities. The urban water services are managed in a centralized way by a state firm which provides for a domestic demand of 63 m3/s of which 50 % is imported from a neighbouring catchment. Half of the water comes from the periurban catchments of the agglomeration which are submitted to a rapid subnormal urbanization with inadequate sanitation arrangement that directly impact the quality of the water. The tensions are likely to increase with the increasing population and difficulties for the sanitation authorities to keep pace with the urbanization processes. Land management is under the responsibility of the municipalities but a specific land legislation to control urbanization in the catchment defined in the 70's did not permit to control urbanization. The implementation since 1995 of an integrated water management policy has permitted to implement multi-stakeholder platforms for water managemen called catchment commiteet, to better articulate land management and water management, as well as to facilitate the participation of civil society in the process. (Résumé d'auteur

Ground-based follow-up observations of TRAPPIST-1 transits in the near-infrared

The TRAPPIST-1 planetary system is a favorable target for the atmospheric characterization of temperate earth-sized exoplanets by means of transmission spectroscopy with the forthcoming James Webb Space Telescope (JWST). A possible obstacle to this technique could come from the photospheric heterogeneity of the host star that could affect planetary signatures in the transit transmission spectra. To constrain further this possibility, we gathered an extensive photometric data set of 25 TRAPPIST-1 transits observed in the near-IR J band (1.2 $\mu$m) with the UKIRT and the AAT, and in the NB2090 band (2.1 $\mu$m) with the VLT during the period 2015-2018. In our analysis of these data, we used a special strategy aiming to ensure uniformity in our measurements and robustness in our conclusions. We reach a photometric precision of $\sim0.003$ (RMS of the residuals), and we detect no significant temporal variations of transit depths of TRAPPIST-1 b, c, e, and g over the period of three years. The few transit depths measured for planets d and f hint towards some level of variability, but more measurements will be required for confirmation. Our depth measurements for planets b and c disagree with the stellar contamination spectra originating from the possible existence of bright spots of temperature 4500 K. We report updated transmission spectra for the six inner planets of the system which are globally flat for planets b and g and some structures are seen for planets c, d, e, and f.Comment: accepted for publication in MNRA

Non-detection of Contamination by Stellar Activity in the Spitzer Transit Light Curves of TRAPPIST-1

We apply the transit light curve self-contamination technique of Morris et al. (2018) to search for the effect of stellar activity on the transits of the ultracool dwarf TRAPPIST-1 with 2018 Spitzer photometry. The self-contamination method fits the transit light curves of planets orbiting spotted stars, allowing the host star to be a source of contaminating positive or negative flux which influences the transit depths but not the ingress/egress durations. We find that none of the planets show statistically significant evidence for self-contamination by bright or dark regions of the stellar photosphere. However, we show that small-scale magnetic activity, analogous in size to the smallest sunspots, could still be lurking in the transit photometry undetected.Comment: Accepted for publication in ApJ

Identification of target-specific bioisosteric fragments from ligand-protein crystallographic data

Bioisosteres are functional groups or atoms that are structurally different but that can form similar intermolecular interactions. Potential bioisosteres were identified here from analysing the X-ray crystallographic structures for sets of different ligands complexed with a fixed protein. The protein was used to align the ligands with each other, and then pairs of ligands compared to identify substructural features with high volume overlap that occurred in approximately the same region of geometric space. The resulting pairs of substructural features can suggest potential bioisosteric replacements for use in lead-optimisation studies. Experiments with 12 sets of ligand-protein complexes from the Protein Data Bank demonstrate the effectiveness of the procedure

Transdisciplinary innovation in irrigated smallholder agriculture in Africa

Boosting the productivity of smallholder farming systems continues to be a major need in Africa. Challenges relating to how to improve irrigation are multi‐factor and multisectoral, and they involve a broad range of actors who must interact to reach decisions collectively. We provide a systematic reflection on findings from the research project EAU4Food, which adopted a transdisciplinary approach to irrigation for food security research in five case studies in Ethiopia, Mali, Mozambique, South Africa and Tunisia. The EAU4Food experiences emphasize that actual innovation at irrigated smallholder farm level remains limited without sufficient improvement of the enabling environment and taking note of the wider political economy environment. Most project partners felt at the end of the project that the transdisciplinary approach has indeed enriched the research process by providing different and multiple insights from actors outside the academic field. Local capacity to facilitate transdisciplinary research and engagement with practitioners was developed and could support the continuation and scaling up of the approach. Future projects may benefit from a longer time frame to allow for deeper exchange of lessons learned among different stakeholders and a dedicated effort to analyse possible improvements of the enabling environment from the beginning of the research process. © 2020 The Authors. Irrigation and Drainage published by John Wiley & Sons Ltd on behalf of International Commission for Irrigation and Drainage

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far