A Pointing Solution for the Medium Size Telescopes for the Cherenkov Telescope Array

An important aspect of the calibration of the Cherenkov Telescope Array is the pointing, which enables an exact alignment of each telescope and therefore allows to transform a position in the sky to a point in the plane of the Cherenkov camera and vice versa. The favoured approach for the pointing calibration of the medium size telescopes (MST) is the installation of an optical CCD-camera in the dish of the telescope that captures the position of the Cherenkov camera and of the stars in the night sky simultaneously during data taking. The adaption of this approach is presented in this proceeding.Comment: 6 pages, 9 figures, Proceedings of the 6th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2016

Gamma-ray burst observations with new generation imaging atmospheric Cerenkov Telescopes in the FERMI era

After the launch and successful beginning of operations of the FERMI satellite, the topics related to high-energy observations of gamma-ray bursts have obtained a considerable attention by the scientific community. Undoubtedly, the diagnostic power of high-energy observations in constraining the emission processes and the physical conditions of gamma-ray burst is relevant. We briefly discuss how gamma-ray burst observations with ground-based imaging array Cerenkov telescopes, in the GeV-TeV range, can compete and cooperate with FERMI observations, in the MeV-GeV range, to allow researchers to obtain a more detailed and complete picture of the prompt and afterglow phases of gamma-ray bursts.Comment: 9 pages, two figures. Proceeding for the 6th "Science with the New Generation of High Energy Gamma-Ray Experiments" worksho

Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis

The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin antagonists inhibit angiogenesis. Although tubulin-inhibiting drugs and their antiangiogenic properties have been investigated for a long time, surprisingly little is known about their underlying mechanisms of action. Antiangiogenic effects of spongistatin 1 were investigated in endothelial cells in vitro, including functional cell-based assays, live-cell imaging, and a kinome array, and in the mouse cornea pocket assay in vivo. Spongistatin 1 inhibited angiogenesis at nanomolar concentrations (IC50: cytotoxicity>50 nM, proliferation 100 pM, migration 1.0 nM, tube formation 1.0 nM, chemotaxis 1.0 nM, aortic ring sprouting 500 pM, neovascularization in vivo 10 μg/kg). Further, a kinome array and validating data showed that spongistatin 1 inhibits the phosphorylation activity of protein kinase Cα (PKCα), an essential kinase in angiogenesis, and its translocation to the membrane. Thus, we conclude that PKCα might be an important target for the antiangiogenic effects of tubulin antagonism. In addition, the data from the kinase array suggest that different tubulin antagonists might have individual intracellular actions.—Rothmeier, A. S., Ischenko, I., Joore, J., Garczarczyk, D., Fu¨rst, R., Bruns, C. J., Vollmar, A. M., Zahler, S. Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis

A method to measure the mirror reflectivity of a prime focus telescope

We have developed a method to measure the mirror reflectivity of telescopes. While it is relatively easy to measure the local reflectivity of the mirror material, it is not so straightforward to measure the amount of light that it focuses in a spot of a given diameter. Our method is based on the use of a CCD camera that is fixed on the mirror dish structure and observes simultaneously part of the telescope's focal plane and the sky region around its optical axis. A white diffuse reflecting disk of known reflectivity is fixed in the telescopes focal plane. During a typical reflectivity measurement the telescope is directed to a selected star. The CCD camera can see two images of the selected star, one directly and another one as a spot focused by the mirror on the white disk. The ratio of the reflected starlight integrated by the CCD from the white disk to the directly measured one provides a precise result of the product of (mirror area x mirror reflectivity)

GRB 050713A: High Energy Observations of the GRB Prompt and Afterglow Emission

Swift discovered GRB 050713A and slewed promptly to begin observing with its narrow field instruments 72.6 seconds after the burst onset, while the prompt gamma-ray emission was still detectable in the BAT. Simultaneous emission from two flares is detected in the BAT and XRT. This burst marks just the second time that the BAT and XRT have simultaneously detected emission from a burst and the first time that both instruments have produced a well sampled, simultaneous dataset covering multiple X-ray flares. The temporal rise and decay parameters of the flares are consistent with the internal shock mechanism. In addition to the Swift coverage of GRB 050713A, we report on the Konus-Wind (K-W) detection of the prompt emission in the energy range 18-1150 keV, an upper limiting GeV measurement of the prompt emission made by the MAGIC imaging atmospheric Cherenkov telescope and XMM-Newton observations of the afterglow. Simultaneous observation between Swift XRT and XMM-Newton produce consistent results, showing a break in the lightcurve at T+~15ks. Together, these four observatories provide unusually broad spectral coverage of the prompt emission and detailed X-ray follow-up of the afterglow for two weeks after the burst trigger. Simultaneous spectral fits of K-W with BAT and BAT with XRT data indicate that an absorbed broken powerlaw is often a better fit to GRB flares than a simple absorbed powerlaw. These spectral results together with the rapid temporal rise and decay of the flares suggest that flares are produced in internal shocks due to late time central engine activity.Comment: 22 pages, 6 tables, 10 figures; Submitted to the Astrophysical Journa

Astroclimatic Characterization of Vallecitos: A candidate site for the Cherenkov Telescope Array at San Pedro Martir

We conducted an 18 month long study of the weather conditions of the Vallecitos, a proposed site in Mexico to harbor the northern array of the Cherenkov Telescope Array (CTA). It is located in Sierra de San Pedro Martir (SPM) a few kilometers away from Observatorio Astron\'omico Nacional. The study is based on data collected by the ATMOSCOPE, a multi-sensor instrument measuring the weather and sky conditions, which was commissioned and built by the CTA Consortium. Additionally, we compare the weather conditions of the optical observatory at SPM to the Vallecitos regarding temperature, humidity, and wind distributions. It appears that the excellent conditions at the optical observatory benefit from the presence of microclimate established in the Vallecitos.Comment: 16 pages, 16 figures, Publication of the Astronomical Society of the Pacific, accepte

Constraints on the steady and pulsed very high energy gamma-ray emission from observations of PSR B1951+32/CTB 80 with the MAGIC Telescope

We report on very high energy gamma-observations with the MAGIC Telescope of the pulsar PSR B1951+32 and its associated nebula, CTB 80. Our data constrain the cutoff energy of the pulsar to be less than 32 GeV, assuming the pulsed gamma-ray emission to be exponentially cut off. The upper limit on the flux of pulsed gamma-ray emission above 75 GeV is 4.3*10^-11 photons cm^-2 sec^-1, and the upper limit on the flux of steady emission above 140 GeV is 1.5*10^-11 photons cm^-2 sec^-1. We discuss our results in the framework of recent model predictions and other studies.Comment: 7 pages, 7 figures, replaced with published versio