Mucoepidermoid carcinoma associated with osteosarcoma in a true malignant mixed tumor of the submandibular region

True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma "de novo." We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma. Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma. Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported

The lesson learnt after Emilia-Romagna earthquakes on precast RC structures: a case-study

During Emilia-Romagna earthquakes (Northern Italy) on May 2012 a huge number of existing precast RC one-story buildings was severely damaged. Most of these structures were reinforced concrete one-story buildings, hosting industrial and commercial activities. The presented paper aims at simulating the structural behavior of an existing precast RC building, damaged during the Emilia-Romagna earthquakes. The direct inspection showed that the most serious damage was related to the connection systems: relative displacements between the beams and the columns; significant dislocations between the roof elements and the beams and some cases of loss of support of the roof elements. Moreover, large rotations were also recorded at the base of the columns. The presented study defines a reliable modeling approach and the dynamic analyses demonstrate the capability of the proposed model in simulating the real response of the structure. The results confirm that the most of the damage was caused by the second seismic event and the numerical evidences agree with the real recorded damage. The numerical outcomes demonstrate the significant influence of the vertical action on the connections behavior/failure

Olfactory evaluation in obstructive sleep apnoea patients

The sense of smell has a high impact on the quality of life. The aim of the present study was to investigate olfactory dysfunction in patients with obstructive sleep apnoea syndrome (OSAS) and correlate the severity of disease with olfactory dysfunction. The relationships between nasal obstruction, nasal mucociliary cleareance and olfactory tests were also evaluated. Sixty patients with a diagnosis of OSAS were enrolled and underwent olfactory function evaluation. In all patients olfactory performance was tested with the Sniffin’ Sticks method. Mucociliary transport times and anterior rhinomanometry were performed to identify eventual nasal obstruction and deficits in nasal mucociliary clearance. Olfactory dysfunction was present in 22 (36.6%) patients of the study group: of these, hyposmia was present in 19 (86.4%) and anosmia in 3 (13.6%). The mean TDI score in the study group was 30. A strong correlation between the olfactory dysfunction and severity of sleep apnoea measured using the AHI was found. Patients with OSA would seem to have a high incidence of olfactory dysfunction. The degree of olfactory dysfunction appears to be related to the severity of disease. However, other co-factors such as nasal obstruction and reduced mucociliary clearance might also play a role in of the aetiology of this condition

Influence of infill panels on the seismic behaviour of a r/c frame designed according to modern buildings codes

It has been broadly shown that presence of infill panels as closing elements of R/C frame buildings has a significant influence on global structural behaviour. Nevertheless, infill elements are not usually considered in the modelling process during the design phase. The present work investigates the effect of infill masonry walls on the dynamic characteristics of a R/C MRF building, designed according to a modern seismic building code, and on its seismic performance at different levels of seismic intensity. An analytical investigation is carried out through eigenvalue analysis on both bare and infilled structure, in order to calibrate the elastic properties of the concrete and infills according to in situ tests; nonlinear static analyses are also performed to characterize the inelastic behaviour. The infill system considerably affects the behaviour of the examined structure, in agreement with earlier studies related to very simple and usually ¿unrealistic¿ structures. This result becomes more reliable due to the consistency between the results of the eigenvalue analysis and the experimental dynamic data

Cyclic shear tests on RC precast beam-to-column connections retrofitted with a three-hinged steel device

Recent European earthquakes demonstrated that the seismic response of RC precast structures can be significantly influenced by the connection systems. Moreover, during past seismic events, many failures of the beam-to-column connections occurred due to their inadequate strength under seismic loads. The seismic safety of these connections has a crucial role in the overall seismic capacity of existing precast structures. A new connection system is employed as a retrofitting solution for a damaged beam-to-column connection and its cyclic shear performance is investigated by means of two cyclic shear tests on two different configurations. In both the experimental tests, the results demonstrate an efficient behavior of the retrofitted connections under horizontal cyclic loads. The comparison between the performance of the investigated connection and the response of a typical beam-to-column dowel connection allows to discuss the main critical features of the dowel connection system

On the seismic design of one-story precast structures for P-Δ effects

P-Δ effects can reduce the seismic safety of structures under seismic actions and they can be vital for one-story precast buildings because of the large flexibility of columns. According to European building code, P-Δ effects can be taken into account by following some design requirements. Such requirements can significantly influence the design of the structures since they may provide the amplification of the seismic demand by means of the stability factor as well as the oversizing of the elements. This study investigates the influence of P-Δ effects on the seismic performance of precast one-story structures. An extensive parametric study is performed on one-story precast structures by varying some geometric features of the structure and the seismicity level of the site. Nonlinear dynamic analyses are performed by using Newmark’s method on all the case studies and the results of the first order and second order analysis are compared and discussed. Moreover, different design approaches are adopted in order to assess the Eurocode provisions for P-Δ effects. The results of the nonlinear dynamic analyses demonstrate that the overstrength, due to seismic detailing of columns and the materials overstrength, induces very low ductility demand for the structures. Indeed, even if P-Δ effects are totally neglected in the design phase, the overstrength due to other code prescriptions (e.g. minimum longitudinal reinforcement ratio) can still induce low ductility demand. Moreover it is demonstrated that the code prescriptions on P-Δ effects do not generally increase the structural safety and an alternative design approach is proposed, which gives both safer and cheaper structures than the ones currently designed according to Eurocodes

Animals-assisted therapy: A brief review

In rehabilitative setting, the presence of animals can be considered as an important stimulus for verbal and social communication, and for mood regulation. Interaction with an animal is beneficial for children's development and numerous psychological tests have revealed that growing up with pets has a beneficial effect on children's self-esteem and self-confidence, can improve empathy, a sense of responsibility and cognitive development, as well as social status within the peer group

Motor skills in children with primary headache: A pilot case-control study

Background: Headache is the most common painful manifestation in the developmental age, often accompanied by severe disability such as scholastic absenteeism, low quality of academic performance and compromised emotional functioning. The aim of the study is to evaluate praxic abilities in a population of children without aural migraine. Materials and methods: The test population consists of 10 subjects without migraine without aura (MwA), (8 Males) (mean age 8.40, SD ± 1.17) and 11 healthy children (7 Males) (mean age 8.27; SD ± 1.10; p = 0.800). All subjects underwent evaluation of motor coordination skills through the Battery for Children Movement Assessment (M-ABC). Results: The two groups (10 MwA vs 11 Controls) were similar for age (8.40 ± 1.17 vs 8.27 ± 1.10; p = 0.800), sex (p = 0.730), and BMI (p = 0.204). The migraine subjects show an average worse performance than the Movement ABC; specifically, migraineurs show significantly higher total score values (31.00 ± 23.65 vs 4.72 ± 2.61; p = 0.001), manual dexterity (12.10 ± 11.20 vs 2.04 ± 2.65; p = 0.009) and balance (14.85 ± 10.08 vs. 1.04 ± 1.05; p <0.001). The mean percentile of migraine performance is significantly reduced compared to controls (9.00 ± 3.82 vs 51.00 ± 24.34, p <0.001) (Table 1). Conclusion: Migraine can alter many cognitive and executive functions such as motor skills in developmental age

Psychopathological and psychodynamic hypotheses for pediatric stuttering

Stuttering is a common language alteration in pediatric age consisting in repetitions and blocks, which entail a break in the rhythm and melody of the speech. According to the WHO it is a disorder of the rhythm of the word, the subject knows precisely what he would like to say, but at the same time he is not able to say it. It is a great inconvenience for those affected, also because the slowing down of speaking is not about thought or cognitive skills

Forensic considerations on violent parasomnias during lifespan

Nocturnal parasomnias are a group of sleep complex manifestation that don't alter the sleep macrostructure, but when persistent during adulthood may be assume violent aspects with relevant forensic implications about the guiltiness