Integration of the CMS regional calorimeter Trigger hardware into the CMS level-1 Trigger

The electronics for the Regional Calorimeter Trigger (RCT) of the Compact Muon Solenoid Experiment (CMS) have been produced and tested. The RCT hardware consists of 18 double-sided crates containing custom boards, ASICs, and backplanes. The RCT receives 8-bit energies and a data quality bit from the HCAL and ECAL Trigger Primitive Generators (TPGs) and sends it to the CMS Global Calorimeter Trigger (GCT) after processing. Before installation, integration tests were performed. Data was successfully received from the TPG electronics and read out with a RCT Jet Capture Card. These tests, other tests involving more trigger subsystems, their results, and the RCT installation will be described

The H\"older Inequality for KMS States

We prove a H\"older inequality for KMS States, which generalises a well-known trace-inequality. Our results are based on the theory of non-commutative $L_p$-spaces.Comment: 10 page

PORE PRESSURE MEASUREMENT INSTRUMENTATION RESPONSE TO BLASTING

Coal mine impoundment failures have been well documented to occur due to an increase in excess pore pressure from sustained monotonic loads. Very few failures have ever occurred from dynamic loading events, such as earthquakes, and research has been done regarding the stability of these impoundment structures under such natural seismic loading events. To date no failures or damage have been reported from dynamic loading events caused by near-by production blasting, however little research has been done considering these conditions. Taking into account that current environmental restrictions oblige to increase the capacity of coal impoundments, thus increasing the hazard of such structures, it is necessary to evaluate the effects of near-by blasting on the stability of the impoundment structures. To study the behavior of excess pore pressure under blasting conditions, scaled simulations of blasting events were set inside a controlled sand tank. Simulated blasts were duplicated in both saturated and unsaturated conditions. Explosive charges were detonated within the sand tank at various distances to simulate different scaled distances. Information was collected from geophones for dry and saturated scenarios and additionally from pressure sensors under saturated conditions to assess the behavior of the material under blasting conditions

Swine embryo development in vitro

Call number: LD2668 .T4 1979 R619Master of Scienc

Gastrinoma and Zollinger-Ellison Syndrome in Canids: A Literature Review and a Case in a Mexican Gray Wolf

Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger–Ellison syndrome in a Mexican gray wolf (Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. A 12-y-old, captive, male Mexican gray wolf developed inappetence and weight loss. Abdominal ultrasonography revealed a thickened duodenum and peritoneal effusion. Two duodenal perforations were noted on exploratory celiotomy and were repaired. Persisting clinical signs led to a second celiotomy that revealed a mesenteric mass, which was diagnosed histologically as a neuroendocrine carcinoma. During the following 16 mo, the wolf received a combination of H2-receptor antagonists, proton-pump inhibitors, gastroprotectants, and anti-emetics, but had recurrent episodes of anorexia, nausea, acid reflux, and remained underweight. Worsening clinical signs and weakness prompted euthanasia. The antemortem serum gastrin concentration of 414 ng/L (reference interval: 10–40 ng/L) corroborated hypergastrinemia. Autopsy revealed a mass expanding the right pancreatic limb; 3 parapancreatic mesenteric masses; duodenal ulcers; focal duodenal perforation with septic fibrinosuppurative peritonitis; chronic-active ulcerative esophagitis; and poor body condition. The pancreatic mass was diagnosed histologically as a neuroendocrine carcinoma and the parapancreatic masses as lymph node metastases. Immunohistochemistry of the pancreatic mass was positive for gastrin and negative for glucagon, insulin, pancreatic polypeptide, serotonin, somatostatin, and vasoactive intestinal peptide

Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning

<p>Abstract</p> <p>Background</p> <p>Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning efficiency tends to decline with the increase of rounds of cloning. It is possible that multiple rounds of cloning compromise the genome integrity or/and introduce epigenetic errors in the resulting cell lines, rendering a decline in cloning. To test these possibilities, we performed 9 high density array Comparative Genomic Hybridization (CGH) experiments to test the genome integrity in 3 independent bovine transgenic cell lineages generated from genetic modification and cloning. Our plan included the control hybridizations (self to self) of the 3 founder cell lines and 6 comparative hybridizations between these founders and their derived cell lines with either high or low cloning efficiencies.</p> <p>Results</p> <p>We detected similar amounts of differences between the control hybridizations (8, 13 and 39 differences) and the comparative analyses of both "high" and "low" cell lines (ranging from 7 to 57 with a mean of ~20). Almost 75% of the large differences (>10 kb) and about 45% of all differences shared the same type (loss or gain) and were located in nearby genomic regions across hybridizations. Therefore, it is likely that they were not true differences but caused by systematic factors associated with local genomic features (e.g. GC contents).</p> <p>Conclusions</p> <p>Our findings reveal that large copy number variations are less likely to arise during genetic targeting and serial rounds of cloning, fortifying the notion that epigenetic errors introduced from serial cloning may be responsible for the cloning efficiency decline.</p

Fungal biosurfactants, from nature to biotechnological product: bioprospection, production and potential applications

Biosurfactants are in demand by the global market as natural commodities that can be added to commercial products or use in environmental applications. These biomolecules reduce the surface/interfacial tension between fluid phases and exhibit superior stability to chemical surfactants under different physico-chemical conditions. Biotechnological production of biosurfactants is still emerging. Fungi are promising producers of these molecules with unique chemical structures, such as sophorolipids, mannosylerythritol lipids, cellobiose lipids, xylolipids, polyol lipids and hydrophobins. In this review, we aimed to contextualize concepts related to fungal biosurfactant production and its application in industry and the environment. Concepts related to the thermodynamic and physico-chemical properties of biosurfactants are presented, which allows detailed analysis of their structural and application. Promising niches for isolating biosurfactant-producing fungi are presented, as well as screening methodologies are discussed. Finally, strategies related to process parameters and variables, simultaneous production, process optimization through statistical and genetic tools, downstream processing and some aspects of commercial products formulations are presented