REVIEW OF IPOMOEA PES-TIGRIDIS L.: ETHNO BOTANICAL CHARACTERISTICS, PHARMACOLOGICAL ACTIVITIES

Nowadays there is a need for scientific justification of plants that have been used in traditional medicine because of loss of information, improvement of therapy and deforestation that is taking place. The majority of the natural products are compounds biosynthetically derived from primary metabolites and are generally categorized as secondary metabolites. These are the major sources of the pharmaceutical industry to discover novel drugs. The basis for interest in natural product chemistry serves as a lead compound for newer drugs, give as much information on possible mechanism and thus on the molecular origin and basis of diseases. Natural products are permanent challenges with respect to total synthesis and stimulate the development of new reagents and reactions. The present study has been taken up to review one of the ethno medicinal significant of Ipomoea pes-tigridis L plant belonging to the family convolvulaceae. The ethno medical information of the plant reveals that the herb Ipomoea pes-tigridis Linn was used as an antidote to dogbite, boils and carbuncles, the leaves were applied as a poultice for boils, carbuncles and sores. The root of this plant was found to possess purgative action. The phytochemical studies on the leaves have been reported for the presence of carbohydrates, proteins and resins

A Siddha Herbal Formulation Alleviates Hypertension in DOCA Salt Induced Hypertensive Rats, Evaluation of Acute, Sub Acute Toxicity, Anti-Oxidant and Diuretic Activity

Vaasathi Kashayam, a Siddha herbal decoction from Agathiyar 2000, is formulated using Adhathoda vasica (Justicia adhatoda L.) leaves and dry grapes (Vitis vinifera L.). This study evaluates its anti-hypertensive, antioxidant, and diuretic effects. Methodology: DOCA-salt-induced hypertensive Wistar albino rats (5 groups, n=6) were treated for 43 days. Blood pressure (BP), serum sodium, and potassium levels were measured. Blood was collected via retro-orbital plexus under ether anesthesia; BP was recorded through cannulated carotid artery using the 2K1C model. Diuretic effect was assessed using 4 groups (n=6) in metabolic cages, measuring total urine volume and Na⁺, K⁺, Cl⁻ levels. Cl⁻ was estimated as NaCl by titration. Antioxidant activity was assessed via DPPH free radical scavenging assay. Acute and subacute toxicity studies followed OECD 423 guidelines. Results: Hypertensive rats had SBP/DBP of 173.33±2.33/145.54±1.23mmHg. Low-dose (200mg/kg) Vaasathi Kashayam reduced BP to 135.03±2.56/92.63±1.01 mmHg, and high-dose (400 mg/kg) to 106.02±3.46/ 72.05±0.53mmHg, comparable to the standard (hydrochlorothiazide) 103.72±1.25/ 92.63±1.82mmHg. Diuretic activity showed increased urine output (32.53±0.83 and 30.67±0.06mL) and elevated urinary electrolytes, comparable to Furosemide. Antioxidant activity peaked at 63.15% inhibition (300µg/mL); standard ascorbic acid showed 132.06% inhibition. No significant toxicity or abnormal changes were observed in acute (up to 2000mg/kg) or subacute (28-day) studies. Conclusion: Vaasathi Kashayam is a safe formulation with significant anti-hypertensive, antioxidant, and diuretic activities, supporting its therapeutic potential in Siddha medicine

Study of Compression Molding of GFRP using Grey Relational Analysis

Abstract Compression moulding is an economical process for processing thermosetting polymers hence finding numerous applications in industries. The moulding parameters like the pressure, temperature and curing time play an important role in influencing the quality characteristics of the manufactured component. The present work is intended to produce fibre glass reinforced epoxy stiffeners using the process of compression moulding for various combinations of input parameters. The input parameters were varied at two levels and a L8 orthogonal array was chosen to perform the trials. Grey relational analysis (GRA) was applied for optimizing the process parameters and ANOVA was performed to identify the contribution of various process parameters

Application of Grey Taguchi based Response Surface Methodology (GT-RSM) in Injection Moulding of Polypropylene/E-glass Composite

Strong non-linearity combined with the complicated rheological behaviour of polymers makes the quality characteristics of products unpredictable in plastic injection moulding. The purpose of this work is to study the mechanical properties of injection moulded polypropylene/E-glass composites. The process parameters like the melt temperature, injection pressure, packing pressure and cooling time were found to influence the quality characteristics of the produced parts. These four parameters were varied at three levels and a L18 orthogonal array was used for designing and conducting the experiments. Tensile and impact strength (Charpy-notched) were observed as the responses and a new integrated technique of grey Taguchi based response surface methodology (GT-RSM) was disclosed to predict the optimal operating condition. A confirmation test was conducted to demonstrate the accuracy of GT-RSM approach. Injection and packing pressure were found to have statistical significance in influencing the strength of injection moulded polypropylene/E-glass composites.</p