ON RESOLVING SCHEMATIC HETEROGENEITY IN MULTIDATABASE SYSTEMS

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Wakota Bridge Thermal Monitoring Program Part I: Analysis and Monitoring Plan

In this work, a common refined design method is evaluated with respect to a recently constructed bridge. Two finite element models of the Wakota Bridge in South St. Paul, Minnesota, were produced, one using a design level program (SAP2000) and the other using a research level program (ABAQUS). These models were verified with respect to each other using linearly elastic materials and were found to behave similarly. After this verification, an arbitrary temperature load was applied to each model and the refined design method was evaluated for accuracy of reduced section properties with respect to the more descriptive progressive cracking solution simulated by ABAQUS. The refined design method was employed using two, four, and six stiffness segments at which stiffness is evaluated along the height of the pier walls. It was seen that accuracy increased as the number of stiffness segments increased and that four segments seemed to balance accuracy and time-commitment by the engineer adequately. A staged construction model of the Wakota Bridge was also built, using the design level program, which incorporates all time-dependent effects of the construction sequence as well as locked-in forces. A pile analysis was performed and appropriate rotational springs were found for Foundations 2 and 3. A simplified method for the determination of the rotational springs is discussed, and a range of effective lengths was found for use with this procedure. The staged construction model is used for field data correlation in Part two of this report. The staged construction model was also used to evaluate the different design options as described in the AASHTO LRFD. The two options given for accounting for reduced section properties were evaluated and compared. The refined analysis option and gross section option were compared for the Wakota Bridge and are shown to correlate to within about 10%. The two temperature application methods (Procedure A and B in the AASHTO LRFD) were also compared. As expected, Procedure B produced much larger design moments than that of Procedure A.Minnesota Department of Transportatio

Early Fever Detection By a Novel Wearable Continuous Temperature Monitor in Patients Undergoing Autologous Stem Cell Transplantation

Introduction Neutropenic fever following high-dose chemotherapy and autologous stem cell transplantation (ASCT) is a common (incidence 63-100%) and potentially life-threatening complication. Recommended time to antibiotic (TTA) administration is within 1 hr of fever onset with delays associated with significant morbidity, prolonged hospitalization, and mortality. Standard of care guidelines emphasize patient self-monitoring for fever, with instructions to seek immediate medical attention if body temperature (temp) reaches 100.4°F or higher. In this study, we evaluated if a novel wearable, continuous temp monitor, tPatch, could reliably estimate core body temp and detect fever in an outpatient setting following ASCT. Additionally, we gathered preliminary data to explore early detection and prediction of clinically relevant temp rise in this clinical setting. Methods Patients (N = 86) with hematologic malignancies (62% multiple myeloma) who underwent high-dose chemotherapy followed by ASCT at Mayo Clinic, MN were prospectively enrolled between June 2018 and March 2019. Patients (82% male) wore an axilla-placed tPatch continuously for 7 days in an outpatient setting during the post ASCT period and were asked to record self-measured oral temp in 3-4 hr intervals daily using a standardized thermometer after appropriate training . Patients followed standard of care procedures with daily clinic assessment of temp, blood counts, and vital signs. An optional patient questionnaire was given at end-of-study. A model was trained using both patient- and clinic-assessed oral temp measures to estimate core temp from 2 sensors on the tPatch device. Core temp estimates and trends were then compared to patient- and clinic-assessed measurements. Fever was defined as a temperature ≥100.4°F for at least 1 hr. Results When compared to all oral temp reads, the tPatch estimated core temp within 0.03 ± 0.7℉. Among the 86 patients, clinic-assessed fever incidence was 29.4% while tPatch-assessed incidence was 58.8%. Using all clinic-recorded temp readings as "ground truth," the sensitivity and specificity of the tPatch algorithm in detecting fevers were 88% and 86%, respectively, while patient self fever detection sensitivity was 62% and specificity 93%. With "fever episode" defined as a temp ≥100.4°F for at least 1 hr, tPatch detected 9.6 times the number of fever episodes vs. clinic reads. The average lead time of tPatch detection of clinic-recorded fevers was 3.7 hours. In 25% of all intervals between clinic temp readings, either tPatch or patients detected at least 1 fever episode. The tPatch was well-tolerated, the only adverse events reported were grade 1 skin irritation and discomfort in 4 (5%) patients. Of 65 patients who completed the survey, 95% reported the tPatch as "quite" or "somewhat" comfortable and 94% stated no difficulty in using the tPatch. Exploration of tPatch temp trends over various time intervals for use in fever prediction is ongoing. Conclusions Patient self-monitoring of temp has low sensitivity and is not feasible for long intervals of time (e.g., overnight). Continuous temperature monitoring by a wearable device overcomes these challenges and has the potential to improve early detection and consequently shorten time to antibiotic initiation. A follow-up randomized study is planned to assess the clinical benefits of continuous temp monitoring through patient and clinician alerts triggering early clinical intervention for febrile neutropenia. Figure Disclosures Vera-Aguilera: Verily Life Sciences: Research Funding. Haji-Abolhassani:Verily Life Sciences: Employment. Kulig:Verily Life Sciences: Employment. Heitz:Verily Life Sciences: Employment. Paludo:Verily Life Sciences: Research Funding; Verily Life Sciences: Research Funding; Celgene: Research Funding; Celgene: Research Funding. Ghoreyshi:Verily Life Sciences: Employment. Scheevel:Verily Life Sciences: Research Funding. Schimke:Verily Life Sciences: Research Funding. Markovic:Verily Life Sciences: Research Funding. </jats:sec

Annual Report 2018-2019: Student Life & Development

Student Life and Development (SLD) professionals at Winona State University (WSU) deliver programs, services, and activities that support students\u27 academic achievement, social development, and well-being in the timely pursuit of their educational goals. The 2018-2019 SLD Annual Report provides information from the following departments: Admissions, Community Engagement, Conduct & Citizenship, Counseling & Wellness, Dean of Students, Health & Wellness Services, Housing & Residence Life, Inclusion & Diversity Office, Integrative Wellness, Student Activities & Leadership, TRIO Student Support Services, the Student Union, the Warrior Hub, and the Warrior Success Center.https://openriver.winona.edu/annualreportssld/1001/thumbnail.jp

Annual Report 2017-2018: Student Life & Development

Student Life and Development (SLD) professionals at Winona State University (WSU) deliver programs, services, and activities that support students\u27 academic achievement, social development, and well-being in the timely pursuit of their educational goals. The 2017-2018 SLD Annual Report provides information from the following departments: Admissions, Community Engagement, Conduct & Citizenship, Counseling & Wellness, Dean of Students, Health & Wellness Services, Housing & Residence Life, Inclusion & Diversity Office, Integrative Wellness, Student Activities & Leadership, TRIO Student Support Services, the Student Union, the Warrior Hub, and the Warrior Success Center.https://openriver.winona.edu/annualreportssld/1002/thumbnail.jp