Defining and delineating the central areas of towns for statistical monitoring using continuous surface representations

The increasing availability of very high spatial resolution data using the unit postcode as its geo-reference is making possible new kinds of urban analysis andmodelling. However, at this resolution the granularity of the data used to representurban functions makes it difficult to apply traditional analytical and modellingmethods. An alternative suggested here is to use kernel density estimation totransform these data from point or area 'objects' into continuous surfaces of spatialdensities. The use of this transformation is illustrated by a study in which we attemptto develop a robust, generally applicable methodology for identifying the centralareas of UK towns for the purpose of statistical reporting and comparison.Continuous density transformations from unit post code data relating to a series ofindicators of town centredness created using ArcView are normalised and thensummed to give a composite ?Index of Town Centredness?. Selection of key contourson these index surfaces enables town centres to be delineated. The work results froma study on behalf of DETR

All Sky Survey Mission Observing Scenario Strategy

This paper develops a general observing strategy for missions performing all-sky surveys, where a single spacecraft maps the celestial sphere subject to realistic constraints. The strategy is flexible such that targeted observations and variable coverage requirements can be achieved. This paper focuses on missions operating in Low Earth Orbit, where the thermal and stray-light constraints due to the Sun, Earth, and Moon result in interacting and dynamic constraints. The approach is applicable to broader mission classes, such as those that operate in different orbits or that survey the Earth. First, the instrument and spacecraft configuration is optimized to enable visibility of the targeted observations throughout the year. Second, a constraint-based high-level strategy is presented for scheduling throughout the year subject to a simplified subset of the constraints. Third, a heuristic-based scheduling algorithm is developed to assign the all-sky observations over short planning horizons. The constraint-based approach guarantees solution feasibility. The approach is applied to the proposed SPHEREx mission, which includes coverage of the North and South Celestial Poles, Galactic plane, and a uniform coverage all-sky survey, and the ability to achieve science requirements demonstrated and visualized. Visualizations demonstrate the how the all-sky survey achieves its objectives

Radio Pulse Properties of the Millisecond Pulsar PSR J0437-4715. I. Observations at 20cm

We present a total of 48 minutes of observations of the nearby, bright millisecond pulsar PSR J0437-4715 taken at the Parkes radio observatory in Australia. The data were obtained at a central radio frequency of 1380 MHz using a high-speed tape recorder that permitted coherent Nyquist sampling of 50 MHz of bandwidth in each of two polarizations. Using the high time resolution available from this voltage recording technique, we have studied a variety of single-pulse properties, most for the first time in a millisecond pulsar. We find no evidence for "diffractive" quantization effects in the individual pulse arrival times or amplitudes as have been reported for this pulsar at lower radio frequency using coarser time resolution (Ables et al. 1997). Overall, we find that the single pulse properties of PSR J0437-4715 are similar to those of the common slow-rotating pulsars, even though this pulsar's magnetosphere and surface magnetic field are several orders of magnitude smaller than those of the general population. The pulsar radio emission mechanism must therefore be insensitive to these fundamental neutron star properties.Comment: 24 Postscript pages, 11 eps figures. Accepted for publication in the Astrophysical Journal. Abbreviated abstract follow

Nanoscale electrochemical patterning reveals the active sites for catechol oxidation at graphite surfaces

Graphite-based electrodes (graphite, graphene, and nanotubes) are used widely in electrochemistry, and there is a long-standing view that graphite step edges are needed to catalyze many reactions, with the basal surface considered to be inert. In the present work, this model was tested directly for the first time using scanning electrochemical cell microscopy reactive patterning and shown to be incorrect. For the electro-oxidation of dopamine as a model process, the reaction rate was measured at high spatial resolution across a surface of highly oriented pyrolytic graphite. Oxidation products left behind in a pattern defined by the scanned electrochemical cell served as surface-site markers, allowing the electrochemical activity to be correlated directly with the graphite structure on the nanoscale. This process produced tens of thousands of electrochemical measurements at different locations across the basal surface, unambiguously revealing it to be highly electrochemically active, with step edges providing no enhanced activity. This new model of graphite electrodes has significant implications for the design of carbon-based biosensors, and the results are additionally important for understanding electrochemical processes on related sp2-hybridized materials such as pristine graphene and nanotubes

Rural to Urban Migration and Changes in Cardiovascular risk Factors in Tanzania: A Prospective Cohort Study.

High levels of rural to urban migration are a feature of most African countries. Our aim was to investigate changes, and their determinants, in cardiovascular risk factors on rural to urban migration in Tanzania. Men and women (15 to 59 years) intending to migrate from Morogoro rural region to Dar es Salaam for at least 6 months were identified. Measurements were made at least one week but no more than one month prior to migration, and 1 to 3 monthly after migration. Outcome measures included body mass index, blood pressure, fasting lipids, and self reported physical activity and diet. One hundred and three men, 106 women, mean age 29 years, were recruited and 132 (63.2%) followed to 12 months. All the figures presented here refer to the difference between baseline and 12 months in these 132 individuals. Vigorous physical activity declined (79.4% to 26.5% in men, 37.8% to 15.6% in women, p < 0.001), and weight increased (2.30 kg men, 2.35 kg women, p < 0.001). Intake of red meat increased, but so did the intake of fresh fruit and vegetables. HDL cholesterol increased in men and women (0.24, 0.25 mmoll-1 respectively, p < 0.001); and in men, not women, total cholesterol increased (0.42 mmoll-1, p = 0.01), and triglycerides fell (0.31 mmoll-1, p = 0.034). Blood pressure appeared to fall in both men and women. For example, in men systolic blood pressure fell by 5.4 mmHg, p = 0.007, and in women by 8.6 mmHg, p = 0.001. The lower level of physical activity and increasing weight will increase the risk of diabetes and cardiovascular disease. However, changes in diet were mixed, and may have contributed to mixed changes in lipid profiles and a lack of rise in blood pressure. A better understanding of the changes occurring on rural to urban migration is needed to guide preventive measures

Nanoscale intermittent contact-scanning electrochemical microscopy

A major theme in scanning electrochemical microscopy (SECM) is a methodology for nanoscale imaging with distance control and positional feedback of the tip. We report the expansion of intermittent contact (IC)-SECM to the nanoscale, using disk-type Pt nanoelectrodes prepared using the laser-puller sealing method. The Pt was exposed using a focused ion beam milling procedure to cut the end of the electrode to a well-defined glass sheath radius, which could also be used to reshape the tips to reduce the size of the glass sheath. This produced nanoelectrodes that were slightly recessed, which was optimal for IC-SECM on the nanoscale, as it served to protect the active part of the tip. A combination of finite element method simulations, steady-state voltammetry and scanning electron microscopy for the measurement of critical dimensions, was used to estimate Pt recession depth. With this knowledge, the tip-substrate alignment could be further estimated by tip approach curve measurements. IC-SECM has been implemented by using a piezo-bender actuator for the detection of damping of the oscillation amplitude of the tip, when IC occurs, which was used as a tip-position feedback mechanism. The piezo-bender actuator improves significantly on the performance of our previous setup for IC-SECM, as the force acting on the sample due to the tip is greatly reduced, allowing studies with more delicate tips. The capability of IC-SECM is illustrated with studies of a model electrode (metal/glass) substrate

The complementarity of astrometric and radial velocity exoplanet observations - Determining exoplanet mass with astrometric snapshots

We obtain full information on the orbital parameters by combining radial velocity and astrometric measurements by means of Bayesian inference. We sample the parameter probability densities of orbital model parameters with a Markov chain Monte Carlo (McMC) method in simulated observational scenarios to test the detectability of planets with orbital periods longer than the observational timelines. We show that, when fitting model parameters simultaneously to measurements from both sources, it is possible to extract much more information from the measurements than when using either source alone. We demonstrate this by studying the orbit of recently found extra-solar planet HD 154345 b.Comment: 6 pages, 9 figures. Accepted to A&

Write-read 3D patterning with a dual-channel nanopipette

Nanopipettes are becoming extremely versatile and powerful tools in nanoscience for a wide variety of applications from imaging to nanoscale sensing. Herein, the capabilities of nanopipettes to architect and build complex free-standing three-dimensional (3D) nanostructures are demonstrated using a simple double-barrel nanopipette device. Electrochemical control of ionic fluxes enables highly localized delivery of precursor species from one channel and simultaneous (dynamic and responsive) ion conductance probe-to-substrate distance feedback with the other for reliable high-quality patterning. Nanopipettes with 30−50 nm tip opening dimensions of each channel allowed confinement of ionic fluxes for the fabrication of high aspect ratio copper pillars, zigzag and Γ-like structures, as well as permitting the subsequent topographical mapping of the patterned features with the same nanopipette probe as used for nanostructure engineering. This approach offers versatility and robustness for high resolution 3D “printing” (writing) and read-out at the nanoscale

Importance of mass transport and spatially heterogeneous flux processes for in situ atomic force microscopy measurements of crystal growth and dissolution kinetics

It is well-established that important information about the dissolution and growth of crystals can be obtained by the investigation of step movement on single-crystal faces via in situ AFM. However, a potential drawback of this approach for kinetic measurements is that the small region of investigation may not be representative of the overall surface. It is shown that the investigation of local processes without accounting for the processes outside the region of interest can lead to significant misinterpretation of the data collected. Taking the case of gypsum dissolution as an example, we critically analyze literature data and develop 3 different finite element method models that treat in detail the coupled mass transport–surface kinetic problem pertaining to dissolution processes in a typical AFM environment. It is shown that mass transport cannot be neglected when performing in situ AFM on macroscopic surfaces even with high-convection fluid cells. Moreover, crystal dissolution kinetics determined by AFM is mainly influenced by processes occurring in areas of the surface outside the region of interest. When this is recognized, and appropriate models are applied, step velocities due to dissolution are consistent with expectations based on macroscopic measurements, and the kinetic gap that is often apparent between nanoscale and macroscopic measurements is closed. This study provides a framework for the detailed analysis of AFM kinetic data that has wide utility and applicability

Frontiers in nanoscale electrochemical imaging : faster, multifunctional and ultrasensitive

A wide range of interfacial physicochemical processes, from electrochemistry to the functioning of living cells involve spatially localized chemical fluxes that are associated with specific features of the interface. Scanning electrochemical probe microscopes (SEPMs) represent a powerful means of visualizing interfacial fluxes, and this Feature Article highlights recent developments that have radically advanced the speed, spatial resolution, functionality and sensitivity of SEPMs. A major trend has been a coming together of SEPMs that developed independently, and the use of established SEPMs in completely new ways, greatly expanding their scope and impact. The focus is on nanopipette-based SEPMs, including scanning ion conductance microscopy (SICM), scanning electrochemical cell microscopy (SECCM), and hybrid techniques thereof, particularly with scanning electrochemical microscopy (SECM). Nanopipette-based probes are made easily, quickly and cheaply with tunable characteristics. They are reproducible and can be fully characterized, and their reponse can be modeled in considerable detail, so that quantitative maps of chemical fluxes and other properties (e.g. local charge) can be obtained and analyzed. This article provides an overview on the use of these probes for high speed imaging, to create movies of electrochemical processes in action, to carry out multifunctional mapping, such as simultaneous topography-charge and topography-activity, and to create nanoscale electrochemical cells for the detection, trapping and analysis of single entities, particularly individual molecules and nanoparticles (NPs). These studies provide a platform for the further application and diversification of SEPMs across a wide range of interfacial science