36 research outputs found
Roflumilast: First approved oral selective PDE4 inhibitor for the treatment of COPD
Get PDFRoflumilast is a first-in-class oral selective anti-inflammatory drug which is a PDE4 inhibitor. It has been approved by regulatory authorities in the Europe and US in 2010 and 2011 respectively for the prevention of acute exacerbations among patients with severe COPD. Since then, the drug has been studies in different populations in clinical trials as well as real world studies. The studies looked at different end points such as the quality of life, improvement in spirometry indices as well as the ability of the drug to prevent exacerbations and hospital admissions. There was a variable response seen in these studies. This article seeks to review the evidence for the role of roflumilast in COPD from these recent studies since its approval.
Keywords: Roflumilast, Exacerbation, Anti-Inflammatory, Phosphodiesterase, COP
A rapid and efficient cycloaddition of simple imines with activated dienes leading to amino sugars; Unusually high “chelation-controlled” diastereoselectivity in the addition to an α,β-dihydroxy imine protected as a ketal.
Full text linkStudies on Chirality Transfer in the [2,3] Sigmatropic Rearrangement of Anions Derived from Trialkylstannylmethyl Allylic Ethers. Stereospecific Synthesis of (2R)-3-Benzyloxy-2-methylpropanol.
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The synthesis of naturally occurring 4-alkyl- and 4-alkenyl-γ-lactones using the asymmetric reducing agent -3-pinanyl-9-borabicyclo[3.3.1]nonane
Full text linkStereochemistry of the allene in the conversion of ethynylalkanol acetates into allenes via organoboranes
Full text linkStereospecific synthesis of hydroxylated steroid side chains. Synthesis of 25,28-dihydroxy-7,8-dihydroergosterol and its c-24 epimer via [2,3] sigmatropic rearrangement.
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