Measure of genuine multipartite entanglement with computable lower bounds

We introduce an intuitive measure of genuine multipartite entanglement which is based on the well-known concurrence. We show how lower bounds on this measure can be derived that also meet important characteristics of an entanglement measure. These lower bounds are experimentally implementable in a feasible way enabling quantification of multipartite entanglement in a broad variety of cases.Comment: 5 pages, 2 figure

Splenic infarction: an update on William Osler\u27s observations.

BACKGROUND: Osler taught that splenic infarction presents with left upper abdominal quadrant pain, tenderness and swelling accompanied by a peritoneal friction rub. Splenic infarction is classically associated with bacterial endocarditis and sickle cell disease. OBJECTIVES: To describe the contemporary experience of splenic infarction. METHODS: We conducted a chart review of inpatients diagnosed with splenic infarction in a Jerusalem hospital between 1990 and 2003. RESULTS: We identified 26 cases with a mean age of 52 years. Common causes were hematologic malignancy (six cases) and intracardiac thrombus (five cases). Only three cases were associated with bacterial endocarditis. In 21 cases the splenic infarction brought a previously undiagnosed underlying disease to attention. Only half the subjects complained of localized left-sided abdominal pain, 36% had left-sided abdominal tenderness; 31% had no signs or symptoms localized to the splenic area, 36% had fever, 56% had leukocytosis and 71% had elevated lactate dehydrogenase levels. One splenectomy was performed and all patients survived to discharge. A post hoc analysis demonstrated that single infarcts were more likely to be associated with fever (20% vs. 63%, p \u3c 0.05) and leukocytosis (75% vs. 33%, P = 0.06) CONCLUSIONS: The clinical presentation of splenic infarction in the modern era differs greatly from the classical teaching, regarding etiology, signs and symptoms. In patients with unexplained splenic infarction, investigation frequently uncovers a new underlying diagnosis

Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells

The human immune system consists of a large number of T cells capable of recognizing and responding to antigens derived from various sources. The development of peptide-major histocompatibility (p/MHC) tetrameric complexes has enabled the direct detection of these antigen-specific T cells. With the goal of increasing throughput and multiplexing of T cell detection, protein microarrays spotted with defined p/MHC complexes have been reported, but studies have been limited due to the inherent instability and reproducibility of arrays produced via conventional spotted methods. Herein, we report on a platform for the detection of antigen-specific T cells on glass substrates that offers significant advantages over existing surface-bound schemes. In this approach, called “Nucleic Acid Cell Sorting (NACS)”, single-stranded DNA oligomers conjugated site-specifically to p/MHC tetramers are employed to immobilize p/MHC tetramers via hybridization to a complementary-printed substrate. Fully assembled p/MHC arrays are used to detect and enumerate T cells captured from cellular suspensions, including primary human T cells collected from cancer patients. NACS arrays outperform conventional spotted arrays assessed in key criteria such as repeatability and homogeneity. The versatility of employing DNA sequences for cell sorting is exploited to enable the programmed, selective release of target populations of immobilized T cells with restriction endonucleases for downstream analysis. Because of the performance, facile and modular assembly of p/MHC tetramer arrays, NACS holds promise as a versatile platform for multiplexed T cell detection

Violation of a Bell inequality in two-dimensional spin-orbit hypoentangled subspaces

Based on spin-orbit coupling induced by q-plates, we present a feasible experimental proposal for preparing two-dimensional spatially inhomogeneous polarizations of light. We further investigate the quantum correlations between these inhomogeneous polarizations of photon pairs generated by spontaneous parametric down-conversion, which in essence describe the so-called hypoentanglement that is established between composite spin-orbit variables of photons. The violation of the Clauser-Horne-Shimony-Holt-Bell inequality is predicted with S=2\sqrt2 to illustrate the entangled nature of the cylindrical symmetry of spatially inhomogeneous polarizations.Comment: 14pages,3 figures, submitte

Quantum uniqueness

In the classical world one can construct two identical systems which have identical behavior and give identical measurement results. We show this to be impossible in the quantum domain. We prove that after the same quantum measurement two different quantum systems cannot yield always identical results, provided the possible measurement results belong to a non orthogonal set. This is interpreted as quantum uniqueness - a quantum feature which has no classical analog. Its tight relation with objective randomness of quantum measurements is discussed.Comment: Presented at 4th Feynman festival, June 22-26, 2009, in Olomouc, Czech Republic

Diseño e implementación de un sistema telefónico para la lectura de repositoríos digitales de información con la finalidad de prestar el servicio a personas con discapacidades visuales

El objetivo principal del presente proyecto fue diseñar e implementar un IVR basado en Asterisk, el cual junto con otras tecnologías fue capaz de leer repositorios digitales como fueron las páginas web de periódicos, diccionarios, la wikipedia, blogs y libros. El sistema inicia recogiendo los datos de páginas web estandarizadas para generar archivos con un formato que permite ser leído por otra herramienta que es capaz de generar archivos de voz, los cuales fueron reproducidos y así el usuario escuchará la información, además de la recepción por medio de comandos de voz para la elección entre los cinco repositorios digitales disponibles. La central telefónica Asterisk permite la comunicación entre las diferentes aplicaciones como son Festival TTS, VXI y Sphinx mediante scripts en lenguaje PHP y Perl. Esta herramienta puede ser adquirida por un bajo costo, es de fácil instalación y mantenimiento, por lo cual podría ser implementada sin problema por alguna institución del gobierno y así las personas obtendrían un nuevo medio de informació

Dificultades en la clasificación del síndrome metabólico: El ejemplo de los adolescentes en México

OBJETIVO. Determinar la diferencia entre las definiciones del National Cholesterol Education Program Adult Treatment Panel (ATPIII) y de la International Diabetes Federation (IDF) para síndrome metabólico (SM) en adolescentes mexicanos. MATERIAL Y MÉTODOS. Estudio transversal en 575 adolescentes de 14 a 16 años. Se utilizaron pruebas t de Student, ji cuadrada y correlación de Spearman. RESULTADOS. La prevalencia de SM fue mayor por ATPIII (18.6%) versus IDF (8.2%) (p<0.001), con 41.1% de concordancia. CONCLUSIONES. Existe una diferencia estadística de la prevalencia del SM en adolescentes mexicanos entre las dos definiciones