Intercomparisons of airborne measurements of aerosol ionic chemical composition during TRACE-P and ACE-Asia

As part of the two field studies, Transport and Chemical Evolution over the Pacific (TRACE-P) and the Asian Aerosol Characterization Experiment (ACE-Asia), the inorganic chemical composition of tropospheric aerosols was measured over the western Pacific from three separate aircraft using various methods. Comparisons are made between the rapid online techniques of the particle into liquid sampler (PILS) for measurement of a suite of fine particle a mist chamber/ion chromatograph (MC/IC) measurement of fine sulfate, and the longer time-integrated filter and micro-orifice impactor (MOI) measurements. Comparisons between identical PILS on two separate aircraft flying in formation showed that they were highly correlated (e.g., sulfate r2 of 0.95), but were systematically different by 10 ± 5% (linear regression slope and 95% confidence bounds), and had generally higher concentrations on the aircraft with a low-turbulence inlet and shorter inlet-to-instrument transmission tubing. Comparisons of PILS and mist chamber measurements of fine sulfate on two different aircraft during formation flying had an r 2 of 0.78 and a relative difference of 39% ± 5%. MOI ionic data integrated to the PILS upper measurement size of 1.3 mm sampling from separate inlets on the same aircraft showed that for sulfate, PILS and MOI were within 14% ± 6% and correlated with an r 2 of 0.87. Most ionic compounds were within ±30%, which is in the range of differences reported between PILS and integrated samplers from ground-based comparisons. In many cases, direct intercomparison between the various instruments is difficult due to differences in upper-size detection limits. However, for this study, the results suggest that the fine particle mass composition measured from aircraft agree to within 30–40%

Probing internal bath dynamics by a Rabi oscillator-based detector

By exact numerical and master equation approaches, we show that a central spin-1/2 can be configured to probe internal bath dynamics. System-bath interactions cause Rabi oscillations in the detector and periodic behavior of fidelity. This period is highly sensitive to the strength of the bath self-interactions, and can be used to calculate the intra-bath coupling

Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review

With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by adults, and 23 others plus the District of Columbia now regulate cannabis use for medical purposes. These policy changes could trigger a broad range of unintended consequences, with profound and lasting implications for the health and social systems in our country. Cannabis use is emerging as one among many interacting factors that can affect brain development and mental function. To inform the political discourse with scientific evidence, the literature was reviewed to identify what is known and not known about the effects of cannabis use on human behavior, including cognition, motivation, and psychosis

A Disc-Corona Model for a Rotating Black Hole

We propose a disc-corona model in which a geometrically thin, optically thick disc surrounds a Kerr black hole, and magnetic fields exert a time-steady torque on the inner edge of the accretion disc. The analytical expression of the total gravitational power is derived from the thin-disc dynamics equations by using this new boundary condition. It is shown that the magnetic torque can considerably enhance the amount of energy released in the disc-corona system. Furthermore, the global solutions of this disc-corona system are obtained numerically. We find that the fraction of the power dissipated into the corona in the total for such disc-corona system increases with the increasing dimensionless black hole spin parameter $a_\ast$, but is insensitive on the $\Delta \varepsilon$ which is the additional radiative efficiency parameter relevant to magnetic torque, for $\Delta\varepsilon > 1$. In addition, the emerged spectra from this disc-corona system are simulated by using Monte-Carlo method, and the effect of the different parameters on the output spectra is discussed

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.

Aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality. H-Ficolin, an innate immune opsonin, is produced by type II alveolar epithelial cells and could participate in lung defences against infections. Here, we used the human type II alveolar epithelial cell line, A549, to determine the involvement of H-ficolin in fungal defence. Additionally, we investigated the presence of H-ficolin in bronchoalveolar lavage fluid from transplant patients during pneumonia. H-Ficolin exhibited demonstrable binding to A. fumigatus conidia via l-fucose, d-mannose and N-acetylglucosamine residues in a calcium- and pH-dependent manner. Moreover, recognition led to lectin complement pathway activation and enhanced fungal association with A549 cells. Following recognition, H-ficolin opsonization manifested an increase in interleukin-8 production from A549 cells, which involved activation of the intracellular signalling pathways mitogen-activated protein kinase MAPK kinase 1/2, p38 MAPK and c-Jun N-terminal kinase. Finally, H-ficolin concentrations were significantly higher in bronchoalveolar lavage fluid of patients with lung infections compared with control subjects (n = 16; P = 0·00726). Receiver operating characteristics curve analysis further highlighted the potential of H-ficolin as a diagnostic marker for lung infection (area under the curve = 0·77; P < 0·0001). Hence, H-ficolin participates in A. fumigatus defence through the activation of the lectin complement pathway, enhanced fungus-host interactions and modulated immune responses

The iron KαK_\alpha lines as a tool for magnetic field estimations in non-flat accretion flows

Observations of AGNs and microquasars by ASCA, RXTE, Chandra and XMM-Newton indicate the existence of broad X-ray emission lines of ionized heavy elements in their spectra. Such spectral lines were discovered also in X-ray spectra of neutron stars and X-ray afterglows of GRBs. Recently, Zakharov et al. (MNRAS, 2003, 342, 1325) described a procedure to estimate an upper limit of the magnetic fields in regions from which X-ray photons are emitted. The authors simulated typical profiles of the iron $K_\alpha$ line in the presence of magnetic field and compared them with observational data in the framework of the widely accepted accretion disk model. Here we further consider typical Zeeman splitting in the framework of a model of non-flat accretion flows, which is a generalization of previous consideration into non-equatorial plane motion of particles emitting X-ray photons. Using perspective facilities of space borne instruments (e.g. Constellation-X mission) a better resolution of the blue peak structure of iron $K_\alpha$ line will allow to evaluate the magnetic fields with higher accuracy.Comment: 22 pages, 6 figure

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes.

addresses: Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry (University of Exeter), Tamar Science Park, Derriford, Plymouth, UK.The final publication is available at link.springer.com/article/10.1007%2Fs00125-010-1817-6In adults, the rate of beta cell replication is normally very low, but recent evidence suggests that it may increase during insulitis. We therefore studied tissue from donors with recent-onset type 1 diabetes to establish whether islet cell proliferation is increased during the disease process